Search Results - "Wang, Falu"

Asymmetric Total Syntheses of Kopsia Indole Alkaloids by Leng, Lingying, Zhou, Xiaohan, Liao, Qi, Wang, Falu, Song, Hao, Zhang, Dan, Liu, Xiao‐Yu, Qin, Yong

“…The asymmetric total syntheses of a group of structurally complex Kopsia alkaloids, (−)‐kopsine, (−)‐isokopsine, (+)‐methyl chanofruticosinate,…”
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Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor by Li, Yueshan, Zhang, Liting, Wang, Yifei, Zou, Jun, Yang, Ruicheng, Luo, Xinling, Wu, Chengyong, Yang, Wei, Tian, Chenyu, Xu, Haixing, Wang, Falu, Yang, Xin, Li, Linli, Yang, Shengyong

“…The retrieval of hit/lead compounds with novel scaffolds during early drug development is an important but challenging task. Various generative models have…”
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A Desulfurative Strategy for the Generation of Alkyl Radicals Enabled by Visible‐Light Photoredox Catalysis by Xue, Fei, Wang, Falu, Liu, Jiazhen, Di, Jiamei, Liao, Qi, Lu, Huifang, Zhu, Min, He, Liping, He, Huan, Zhang, Dan, Song, Hao, Liu, Xiao‐Yu, Qin, Yong

“…Herein, we present a new desulfurative method for generating primary, secondary, and tertiary alkyl radicals through visible‐light photoredox catalysis. A…”
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Selective and Efficient Reduction of Nitrate to Gaseous Nitrogen from Drinking Water Source by UV/Oxalic Acid/Ferric Iron Systems: Effectiveness and Mechanisms by Zhiyuan Shi, Falu Wang, Qian Xiao, Shuili Yu, Xingli Ji

“…Nitrate (NO3−) reduction in water has been receiving increasing attention in water treatment due to its carcinogenic and endocrine-disrupting properties. This…”
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A new generation Mpro inhibitor with potent activity against SARS-CoV-2 Omicron variants by Huang, Chong, Shuai, Huiping, Qiao, Jingxin, Hou, Yuxin, Zeng, Rui, Xia, Anjie, Xie, Lingwan, Fang, Zhen, Li, Yueyue, Yoon, Chaemin, Huang, Qiao, Hu, Bingjie, You, Jing, Quan, Baoxue, Zhao, Xiu, Guo, Nihong, Zhang, Shiyu, Ma, Ronggang, Zhang, Jiahao, Wang, Yifei, Yang, Ruicheng, Zhang, Shanshan, Nan, Jinshan, Xu, Haixing, Wang, Falu, Lei, Jian, Chu, Hin, Yang, Shengyong

“…Emerging SARS-CoV-2 variants, particularly the Omicron variant and its sublineages, continually threaten the global public health. Small molecule antivirals…”
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A Desulfurative Strategy for the Generation of Alkyl Radicals Enabled by Visible‐Light Photoredox Catalysis by Xue, Fei, Wang, Falu, Liu, Jiazhen, Di, Jiamei, Liao, Qi, Lu, Huifang, Zhu, Min, He, Liping, He, Huan, Zhang, Dan, Song, Hao, Liu, Xiao‐Yu, Qin, Yong

“…Herein, we present a new desulfurative method for generating primary, secondary, and tertiary alkyl radicals through visible‐light photoredox catalysis. A…”
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Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis by Jiao, Yan, Nan, Jinshan, Mu, Bo, Zhang, Yun, Zhou, Nenghua, Yang, Shunhua, Zhang, Shanshan, Lin, Wanting, Wang, Falu, Xia, Anjie, Cao, Zhixing, Chen, Pei, Pan, Zhiling, Lin, Guifeng, Pan, Shulei, Bin, Huachao, Li, Linli, Yang, Shengyong

“…The NLRP3 inflammasome, which regulated a proinflammatory programmed cell death form termed pyroptosis, is involved in the pathological process of various…”
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Structural Optimization and Structure-Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants by Pan, Shulei, Zhang, Liting, Luo, Xinling, Nan, Jinshan, Yang, Wei, Bin, Huachao, Li, Yang, Huang, Qiao, Wang, Tianqi, Pan, Zhiling, Mu, Bo, Wang, Falu, Tian, Chenyu, Liu, Yang, Li, Linli, Yang, Shengyong

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Discovery of benzodiazepine derivatives as a new class of covalent inhibitors of SARS-CoV–2 main protease by Wang, Falu, Zeng, Rui, Qiao, Jingxin, Xia, Anjie, Li, Yueshan, Li, Feng, Wu, Yunjie, Liu, Yuanzhi, Zhao, Xiu, Lei, Jian, Yang, Shengyong

“…[Display omitted] The COVID-19 pandemic has caused people immense suffering all over the world. Although the World Health Organization (WHO) has announced the…”
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Structural Optimization and Structure-Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6 H -pyrimido[5,4- b ][1,4]oxazin-7(8 H )-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants by Pan, Shulei, Zhang, Liting, Luo, Xinling, Nan, Jinshan, Yang, Wei, Bin, Huachao, Li, Yang, Huang, Qiao, Wang, Tianqi, Pan, Zhiling, Mu, Bo, Wang, Falu, Tian, Chenyu, Liu, Yang, Li, Linli, Yang, Shengyong

“…Tropomyosin receptor kinases (TrkA, TrkB, and TrkC) are attractive therapeutic targets for multiple cancers. Two first-generation small-molecule Trks…”
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Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo by Bin, Huachao, Chen, Pei, Wu, Ming, Wang, Falu, Lin, Guifeng, Pan, Shulei, Liu, Jingming, Mu, Bo, Nan, Jinshan, Huang, Qiao, Li, Linli, Yang, Shengyong

“…Ataxia telangiectasia mutated and Rad3-related (ATR) kinase is an important regulator of the DNA damage response (DDR), especially in response to replication…”
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An Acid/Base-Regulated Recyclable Strategy for Homogeneous Cinchona Alkaloid-Derived Primary Amine Organocatalysts in Aldol, Vinylogous Michael and Double-Michael Cascade Reactions by Wan, Jingwei, Zhao, Zhiwei, Wang, Falu, Ma, Xuebing

“…A practical, recyclable strategy for homogeneous cinchona alkaloid‐derived primary amine organocatalysts was developed by controlling the solubilities in an…”
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A new generation M pro inhibitor with potent activity against SARS-CoV-2 Omicron variants by Huang, Chong, Shuai, Huiping, Qiao, Jingxin, Hou, Yuxin, Zeng, Rui, Xia, Anjie, Xie, Lingwan, Fang, Zhen, Li, Yueyue, Yoon, Chaemin, Huang, Qiao, Hu, Bingjie, You, Jing, Quan, Baoxue, Zhao, Xiu, Guo, Nihong, Zhang, Shiyu, Ma, Ronggang, Zhang, Jiahao, Wang, Yifei, Yang, Ruicheng, Zhang, Shanshan, Nan, Jinshan, Xu, Haixing, Wang, Falu, Lei, Jian, Chu, Hin, Yang, Shengyong

“…Emerging SARS-CoV-2 variants, particularly the Omicron variant and its sublineages, continually threaten the global public health. Small molecule antivirals…”
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Asymmetric Total Syntheses of Kopsia Indole Alkaloids by Leng, Lingying, Zhou, Xiaohan, Liao, Qi, Wang, Falu, Song, Hao, Zhang, Dan, Liu, Xiao‐Yu, Qin, Yong

“…The asymmetric total syntheses of a group of structurally complex Kopsia alkaloids, (−)‐kopsine, (−)‐isokopsine, (+)‐methyl chanofruticosinate,…”
Get full text