Magnetic Microdevices for MRI-Based Detection of SARS-CoV-2 Viruses

Magnetic Microdevices for MRI-Based Detection of SARS-CoV-2 Viruses

Goal: To develop a micron-scale device that can operate as an MRI-based reporter for the presence of SARS-CoV-2 virus. Methods: Iron rod microdevices were constructed via template-guided synthesis and suspended in phosphate buffered saline (PBS). Heat-inactivated SARS-CoV-2 viruses were added to the...

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Bibliographic Details
Published in:IEEE open journal of engineering in medicine and biology Vol. 1; pp. 265 - 267
Main Authors: Mair, Lamar O., Hale, Olivia, Jafari, Sahar, Chen, Cheng, Udalov, Oleg, Probst, Roland, Baum, Ittai, Hevaganinge, Anjana, Wang, Elaine Yi, Rodriguez, Olga C., Albanese, Christopher, Fricke, Stanley T., Weinberg, Irving N.
Format: Journal Article
Language:English
Published: United States IEEE 01-01-2020
The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects:
Biomedical engineering
Coronavirus
COVID
Electron micrographs
Iron
Low concentrations
magnetic microdevices
Magnetic resonance imaging
Magnetic shielding
Micromagnetics
MRI
Scanning electron microscopy
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
theranostic
Viral diseases
Viruses
Viruses (medical)
COVID
coronavirus
magnetic microdevices
theranostic
MRI
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Summary:Goal: To develop a micron-scale device that can operate as an MRI-based reporter for the presence of SARS-CoV-2 virus. Methods: Iron rod microdevices were constructed via template-guided synthesis and suspended in phosphate buffered saline (PBS). Heat-inactivated SARS-CoV-2 viruses were added to the samples and imaged with low-field MRI. Results: MRI of microdevices and viruses showed decreased signal intensity at low concentrations of viruses that recovered at higher concentrations. Electron micrographs suggest that reduced MRI intensity may be due to concentration-dependent shielding of water protons from local magnetic inhomogeneities caused by the iron microdevices. Conclusions: The preliminary results presented in this letter provide justification for further studies exploring the potential diagnostic role of magnetic microdevices in assessing the presence and concentration of SARS-CoV-2 viruses.
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ISSN:2644-1276
2644-1276
DOI:10.1109/OJEMB.2020.3026234