Search Results - "Wang, Edward W"

Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer by Nath, Aritro, Cosgrove, Patrick A., Mirsafian, Hoda, Christie, Elizabeth L., Pflieger, Lance, Copeland, Benjamin, Majumdar, Sumana, Cristea, Mihaela C., Han, Ernest S., Lee, Stephen J., Wang, Edward W., Fereday, Sian, Traficante, Nadia, Salgia, Ravi, Werner, Theresa, Cohen, Adam L., Moos, Philip, Chang, Jeffrey T., Bowtell, David D. L., Bild, Andrea H.

“…The evolution of resistance in high-grade serous ovarian cancer (HGSOC) cells following chemotherapy is only partially understood. To understand the selection…”
Get full text

Targeting PARG induces tumor cell growth inhibition and antitumor immune response by reducing phosphorylated STAT3 in ovarian cancer by Martincuks, Antons, Zhang, Chunyan, Austria, Theresa, Li, Yi-Jia, Huang, Rui, Lugo Santiago, Nicole, Kohut, Adrian, Zhao, Qianqian, Borrero, Rosemarie Martinez, Shen, Binghui, Cristea, Mihaela, Wang, Edward W, Song, Mihae, Rodriguez-Rodriguez, Lorna, Yu, Hua

“…BackgroundOvarian cancer is the most lethal gynecological malignancy, with limited treatment options after failure of standard therapies. Despite the potential…”
Get full text

Dual PD-1 and CTLA-4 Checkpoint Blockade Using Balstilimab and Zalifrelimab Combination as Second-Line Treatment for Advanced Cervical Cancer: An Open-Label Phase II Study by O'Malley, David M, Neffa, Maryna, Monk, Bradley J, Melkadze, Tamar, Huang, Marilyn, Kryzhanivska, Anna, Bulat, Iurie, Meniawy, Tarek M, Bagameri, Andrea, Wang, Edward W, Doger de Speville Uribe, Bernard, Hegg, Roberto, Ortuzar Feliu, Waldo, Ancukiewicz, Marek, Lugowska, Iwona

“…Balstilimab (antiprogrammed death-1) and zalifrelimab (anticytotoxic T-lymphocyte-associated antigen-4) are two new checkpoint inhibitors emerging as promising…”
Get full text

Selective Reversible Inhibition of Autophagy in Hypoxic Breast Cancer Cells Promotes Pulmonary Metastasis by Dower, Christopher M, Bhat, Neema, Wang, Edward W, Wang, Hong-Gang

“…Autophagy influences how cancer cells respond to nutrient deprivation and hypoxic stress, two hallmarks of the tumor microenvironment (TME). In this study, we…”
Get full text

Impact of Sodium Thiosulfate on Prevention of Nephrotoxicities in HIPEC: An Ancillary Evaluation of Cisplatin-Induced Toxicities in Ovarian Cancer by Senguttuvan, Rosemary N., Santiago, Nicole Lugo, Han, Ernest S., Lee, Byrne, Lee, Stephen, Lin, Wei-Chien, Kebria, Mehdi, Hakim, Amy, Lin, Jeff F., Wakabayashi, Mark T., Ruel, Nora, Tinsley, Raechelle, Eng, Melissa, Stewart, Daphne B., Wang, Edward W., Paz, Benjamin I., Wu, Xiwei, Cho, Hyejin, Liang, Winnie S., Rodriguez-Rodriguez, Lorna, Cristea, Mihaela C., Raoof, Mustafa, Dellinger, Thanh H.

“…Purpose Hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin confers a survival benefit in epithelial ovarian cancer (EOC) but is associated with…”
Get full text

ASO Visual Abstract: Impact of Sodium Thiosulfate on Prevention of Nephrotoxicities in HIPEC: An Ancillary Evaluation of Cisplatin-Induced Toxicities in Ovarian Cancer by Senguttuvan, Rosemary Noel, Santiago, Nicole Lugo, Han, Ernest S., Lee, Byrne, Lee, Stephen, Lin, Wei-Chien, Kebria, Mehdi, Hakim, Amy, Lin, Jeff F., Wakabayashi, Mark T., Ruel, Nora, Tinsley, Raechelle, Eng, Melissa, Stewart, Daphne B., Wang, Edward W., Paz, Benjamin I., Wu, Xiwei, Cho, Hyejin, Liang, Winnie S., Rodriguez-Rodriguez, Lorna, Cristea, Mihaela C., Raoof, Mustafa, Dellinger, Thanh H.

Get full text

A phase III, multicenter, randomized study of olvimulogene nanivacirepvec followed by platinum-doublet chemotherapy and bevacizumab compared with platinum-doublet chemotherapy and bevacizumab in women with platinum-resistant/refractory ovarian cancer by Holloway, Robert W, Thaker, Premal, Mendivil, Alberto A, Ahmad, Sarfraz, Al-Niaimi, Ahmed N, Barter, James, Beck, Tiffany, Chambers, Setsuko K, Coleman, Robert L, Crafton, Sarah M, Crane, Erin, Ramez, Eskander, Ghamande, Sharad, Graybill, Whitney, Herzog, Thomas, Indermaur, Megan Dr, John, Veena S, Landrum, Lisa, Lim, Peter C, Lucci, Joseph A, McHale, Michael, Monk, Bradley J, Moore, Kathleen Nadine, Morris, Robert, O'Malley, David M, Reid, Thomas J, Richardson, Debra, Rose, Peter G, Scalici, Jennifer M, Silasi, Dan-Arin, Tewari, Krishnansu, Wang, Edward W

“…Treatment options for patients with platinum-resistant/refractory ovarian cancers are limited and only marginally effective. The development of novel, more…”
Get more information

Evaluation of Somatic Mutations in Solid Metastatic Pan-Cancer Patients by Roosan, Moom R, Mambetsariev, Isa, Pharaon, Rebecca, Fricke, Jeremy, Baroz, Angel R, Chao, Joseph, Chen, Chen, Nasser, Mohd W, Chirravuri-Venkata, Ramakanth, Jain, Maneesh, Smith, Lynette, Yost, Susan E, Reckamp, Karen L, Pillai, Raju, Arvanitis, Leonidas, Afkhami, Michelle, Wang, Edward W, Chung, Vincent, Cristea, Mihaela, Fakih, Marwan, Koczywas, Marianna, Massarelli, Erminia, Mortimer, Joanne, Yuan, Yuan, Batra, Surinder K, Pal, Sumanta, Salgia, Ravi

“…Metastasis continues to be the primary cause of all cancer-related deaths despite the recent advancements in cancer treatments. To evaluate the role of…”
Get full text

First-in-Human Phase 1b Trial of Quinacrine Plus Capecitabine in Patients With Refractory Metastatic Colorectal Cancer by Winer, Arthur, Denlinger, Crystal S., Vijayvergia, Namrata, Cohen, Steven J., Astaturov, Igor, Dotan, Efrat, Gallant, Jean-Nicolas, Wang, Edward W., Kunkel, Miriam, Lim, Bora, Harvey, Harold A., Sivik, Jeffrey, Korzekwa, Kenneth, Ruth, Karen, White, Kevin, Cooper, Harry S., Ross, Eric A., Zhou, Lanlan, El-Deiry, Wafik S.

“…Quinacrine plus a fluoropyrimidine has in vivo efficacy against metastatic colorectal cancer (mCRC). This phase 1b trial evaluated the combination of…”
Get full text

Hyperthermic Intraperitoneal Chemotherapy-Induced Molecular Changes in Humans Validate Preclinical Data in Ovarian Cancer by Dellinger, Thanh H, Han, Ernest S, Raoof, Mustafa, Lee, Byrne, Wu, Xiwei, Cho, Hyejin, He, Ting-Fang, Lee, Peter, Razavi, Marianne, Liang, Winnie S, Schmolze, Daniel, Priceman, Saul J, Lee, Stephen, Lin, Wei-Chien, Lin, Jeff F, Kebria, Mehdi, Hakim, Amy, Ruel, Nora, Stewart, Daphne B, Wang, Edward W, Paz, Benjamin I, Wakabayashi, Mark T, Cristea, Mihaela C, Rodriguez-Rodriguez, Lorna

“…Hyperthermic intraperitoneal chemotherapy (HIPEC) confers a survival benefit in epithelial ovarian cancer (EOC) and in preclinical models. However, the…”
Get more information

Abstract 1153: Targeting CA125 transcription for ovarian cancer treatment by Yue, Er, Yang, Guangchao, Yao, Yuanfei, Wang, Guangyu, Zhang, Yanqiao, Wang, Edward W.

“…Abstract CA125 coded by MUC16 gene is highly expressed in most ovarian cancer cells and serves as a tumor marker to monitor disease progression or response to…”
Get full text

Abstract 2739: Genetic modification of mesothelial cells with full length membrane-bound TRAIL for ovarian cancer treatment by Yue, Er, Walser, Tonya, Mirzapoiazova, Tamara, Salgia, Ravi, Wang, Edward W.

“…Abstract Mesothelial cells lining the peritoneum play an important role in epithelial ovarian cancer (EOC) locoregional spreading by promoting cancer cell…”
Get full text

A phase ib trial to evaluate the safety and efficacy of quinacrine plus capecitabine in patients with refractory metastatic colorectal cancer by Winer, Arthur, Vijayvergia, Namrata, Cohen, Steven J., Denlinger, Crystal S., Astsaturov, Igor A., Dotan, Efrat, Gallant, Jean-Nicolas, Wang, Edward W, Kunkel, Miriam, Lim, Bora, Harvey, Harold A., Sivik, Jeffrey Michael, Zhou, Lanlan, Korzekwa, Kenneth, Ruth, Karen, Ross, Eric A., El-Deiry, Wafik S.

“…Abstract only e15020 Background: Acridines emerged from a cell-based screen for p53-pathway restoring compounds. Quinacrine, an acridine demonstrating p53…”
Get full text

Regnase-1, a rapid response ribonuclease regulating nflammation and stress responses by Renfang Mao Riyun Yang Xia Chen Edward W Harhaj Xiaoying Wang Yihui Fan

“…RNA-binding proteins （RBPs） are central players in post-transcriptional regulation and immune homeostasis. The ribonuclease and RBP Regnase-1 exerts critical…”
Get full text