Search Results - "Wang, Derek W."

Dantrolene enhances antisense-mediated exon skipping in human and mouse models of Duchenne muscular dystrophy by Kendall, Genevieve C, Mokhonova, Ekaterina I, Moran, Miriana, Sejbuk, Natalia E, Wang, Derek W, Silva, Oscar, Wang, Richard T, Martinez, Leonel, Lu, Qi L, Damoiseaux, Robert, Spencer, Melissa J, Nelson, Stanley F, Miceli, M Carrie

“…Duchenne muscular dystrophy (DMD) causes profound and progressive muscle weakness and loss, resulting in early death. DMD is usually caused by frameshifting…”
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Single nuclei transcriptomics of muscle reveals intra-muscular cell dynamics linked to dystrophin loss and rescue by Scripture-Adams, Deirdre D., Chesmore, Kevin N., Barthélémy, Florian, Wang, Richard T., Nieves-Rodriguez, Shirley, Wang, Derek W., Mokhonova, Ekaterina I., Douine, Emilie D., Wan, Jijun, Little, Isaiah, Rabichow, Laura N., Nelson, Stanley F., Miceli, M. Carrie

“…In Duchenne muscular dystrophy, dystrophin loss leads to chronic muscle damage, dysregulation of repair, fibro-fatty replacement, and weakness. We develop…”
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Repurposing Dantrolene for Long-Term Combination Therapy to Potentiate Antisense-Mediated DMD Exon Skipping in the mdx Mouse by Wang, Derek W., Mokhonova, Ekaterina I., Kendall, Genevieve C., Becerra, Diana, Naeini, Yalda B., Cantor, Rita M., Spencer, Melissa J., Nelson, Stanley F., Miceli, M. Carrie

“…Duchenne muscular dystrophy (DMD) is caused by mutations in DMD, resulting in loss of dystrophin, which is essential to muscle health. DMD “exon skipping” uses…”
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