Search Results - "Wang, Degeng"

Nanocarrier-Mediated Chemo-Immunotherapy Arrested Cancer Progression and Induced Tumor Dormancy in Desmoplastic Melanoma by Liu, Qi, Chen, Fengqian, Hou, Lin, Shen, Limei, Zhang, Xueqiong, Wang, Degeng, Huang, Leaf

“…In desmoplastic melanoma, tumor cells and tumor-associated fibroblasts are the major dominators playing a critical role in the fibrosis morphology as well as…”
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Discrepancy between mRNA and protein abundance: Insight from information retrieval process in computers by Wang, Degeng

“…Discrepancy between the abundance of cognate protein and RNA molecules is frequently observed. A theoretical understanding of this discrepancy remains elusive,…”
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The Pattern of microRNA Binding Site Distribution by Zhang, Fangyuan, Wang, Degeng

“…Micro-RNA (miRNA or miR) regulates at least 60% of the genes in the human genome through their target sites at mRNA 3'-untranslated regions (UTR), and defects…”
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Non-Linear Relationship between MiRNA Regulatory Activity and Binding Site Counts on Target mRNAs by Tian, Shuangmei, Zhao, Ziyu, Ren, Beibei, Wang, Degeng

“…MicroRNAs (miRNA) exert regulatory actions via base pairing with their binding sites on target mRNAs. Cooperative binding, i.e., synergism, among binding sites…”
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The Enrichment of miRNA-Targeted mRNAs in Translationally Less Active over More Active Polysomes by Wang, Tingzeng, Tian, Shuangmei, Tikhonova, Elena B, Karamyshev, Andrey L, Wang, Jing J, Zhang, Fangyuan, Wang, Degeng

“…miRNAs moderately inhibit the translation and enhance the degradation of their target mRNAs via cognate binding sites located predominantly in the…”
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Monitoring cyanobacterial toxins in a large reservoir: relationships with water quality parameters by Subbiah, Seenivasan, Karnjanapiboonwong, Adcharee, Maul, Jonathan D, Wang, Degeng, Anderson, Todd A

“…Cyanobacteria are widely distributed in fresh, brackish, and ocean water environments, as well as in soil and on moist surfaces. Changes in the population of…”
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Comparing transcription rate and mRNA abundance as parameters for biochemical pathway and network analysis by Hayles, Brewster, Yellaboina, Sailu, Wang, Degeng

“…The cells adapt to extra- and intra-cellular signals by dynamic orchestration of activities of pathways in the biochemical networks. Dynamic control of the…”
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Negative Elongation Factor Controls Energy Homeostasis in Cardiomyocytes by Pan, Haihui, Qin, Kunhua, Guo, Zhanyong, Ma, Yonggang, April, Craig, Gao, Xiaoli, Andrews, Thomas G., Bokov, Alex, Zhang, Jianhua, Chen, Yidong, Weintraub, Susan T., Fan, Jian-Bing, Wang, Degeng, Hu, Yanfen, Aune, Gregory J., Lindsey, Merry L., Li, Rong

“…Negative elongation factor (NELF) is known to enforce promoter-proximal pausing of RNA polymerase II (Pol II), a pervasive phenomenon observed across…”
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Regulated Subset of G1 Growth-Control Genes in Response to Derepression by the Wnt Pathway by Baek, Sung Hee, Kioussi, Chrissa, Briata, Paola, Wang, Degeng, Nguyen, H. D., Ohgi, Kenneth A., Glass, Christopher K., Wynshaw-Boris, Anthony, Rose, David W., Rosenfeld, Michael G.

“…Pitx2 is a bicoid-related homeodomain factor that is required for effective cell type-specific proliferation directly activating a specific growth-regulating…”
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Systematic Trans-Genomic Comparison of Protein Kinases between Arabidopsis and Saccharomyces cerevisiae by Wang, Degeng, Harper, Jeffrey F., Gribskov, Michael

“…The genome of the budding yeast (Saccharomyces cerevisiae) provides an important paradigm for transgenomic comparisons with other eukaryotic species. Here, we…”
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Examining the architecture of cellular computing through a comparative study with a computer by Wang, Degeng, Gribskov, Michael

“…The computer and the cell both use information embedded in simple coding, the binary software code and the quadruple genomic code, respectively, to support…”
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Activation of the TGFα autocrine loop is downstream of IGF-I receptor activation during mitogenesis in growth factor dependent human colon carcinoma cells by DEGENG WANG, PATIL, Sandip, WENHUI LI, HUMPHREY, Lisa E, BRATTAIN, Michael G, HOWELL, Gillian M

“…The inappropriate expression of TGFα in growth arrest contributes to malignant progression in human colon carcinoma cells. Early stage, non-progressed colon…”
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R-Spondin1/LGR5 Activates TGFβ Signaling and Suppresses Colon Cancer Metastasis by Zhou, Xiaolin, Geng, Liying, Wang, Degeng, Yi, Haowei, Talmon, Geoffrey, Wang, Jing

“…Leucine-rich repeat containing G-protein-coupled receptor 5 (LGR5), an intestinal stem cell marker, is known to exhibit tumor suppressor activity in colon…”
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Nanoparticle-Mediated Trapping of Wnt Family Member 5A in Tumor Microenvironments Enhances Immunotherapy for B‑Raf Proto-Oncogene Mutant Melanoma by Liu, Qi, Zhu, Hongda, Tiruthani, Karthik, Shen, Limei, Chen, Fengqian, Gao, Keliang, Zhang, Xueqiong, Hou, Lin, Wang, Degeng, Liu, Rihe, Huang, Leaf

“…Development of an effective treatment against advanced tumors remains a major challenge for cancer immunotherapy. Approximately 50% of human melanoma is driven…”
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Perfluoroalkylsulfonic and carboxylic acids in earthworms (Eisenia fetida): Accumulation and effects results from spiked soils at PFAS concentrations bracketing environmental relevance by Karnjanapiboonwong, Adcharee, Deb, Sanjit K., Subbiah, Seenivasan, Wang, Degeng, Anderson, Todd A.

“…Effects of perfluorobutanesulfonic acid (PFBS), perfluorohexanesulfonic acid (PFHxS), perfluorononanoic acid (PFNA), and perfluoroheptanoic acid (PFHpA) on…”
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Comparative Analysis of microRNA Binding Site Distribution and microRNA-Mediated Gene Expression Repression of Oncogenes and Tumor Suppressor Genes by Tian, Shuangmei, Wang, Jing, Zhang, Fangyuan, Wang, Degeng

“…MicroRNAs (miRNAs) are a family of short, noncoding RNAs that can regulate gene expression levels of over half of the human genome. Previous studies on the…”
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Uncovering the cellular capacity for intensive and specific feedback self-control of the argonautes and MicroRNA targeting activity by Wang, Degeng, Wang, Tingzeng, Gill, Audrey, Hilliard, Terrell, Chen, Fengqian, Karamyshev, Andrey L, Zhang, Fangyuan

“…Abstract The miRNA pathway has three segments—biogenesis, targeting and downstream regulatory effectors. We aimed to better understand their cellular control…”
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Nanocarrier-Mediated Chemo-Immuno Therapy Arrested Cancer Progression and Induced Tumor Dormancy in Desmoplastic Melanoma by Liu, Qi, Chen, Fengqian, Hou, Lin, Shen, Limei, Zhang, Xueqiong, Wang, Degeng, Huang, Leaf

“…In desmoplastic melanoma, tumor cells and tumor-associated fibroblasts are the major dominators playing a critical role in the fibrosis morphology as well as…”
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Relationship between gene duplicability and diversifiability in the topology of biochemical networks by Guo, Zhanyong, Jiang, Wen, Lages, Nuno, Borcherds, Wade, Wang, Degeng

“…Selective gene duplicability, the extensive expansion of a small number of gene families, is universal. Quantitatively, the number of genes (P(K)) with K…”
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A Multi-Parameter Analysis of Cellular Coordination of Major Transcriptome Regulation Mechanisms by Jiang, Wen, Guo, Zhanyong, Lages, Nuno, Zheng, W. Jim, Feliers, Denis, Zhang, Fangyuan, Wang, Degeng

“…To understand cellular coordination of multiple transcriptome regulation mechanisms, we simultaneously measured transcription rate (TR), mRNA abundance (RA)…”
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