Search Results - "Wang, Conan K."

Cyclic peptide oral bioavailability: Lessons from the past by Wang, Conan K, Craik, David J.

“…Achieving high oral bioavailability for drugs is a key design objective in drug development. It is not surprising then that with the growing expectation of…”
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EGF‐like and Other Disulfide‐rich Microdomains as Therapeutic Scaffolds by Tombling, Benjamin J., Wang, Conan K., Craik, David J.

“…Disulfide bonds typically introduce conformational constraints into peptides and proteins, conferring improved biopharmaceutical properties and greater…”
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Conformational Flexibility Is a Determinant of Permeability for Cyclosporin by Wang, Conan K, Swedberg, Joakim E, Harvey, Peta J, Kaas, Quentin, Craik, David J

“…Several cyclic peptides have been reported to have unexpectedly high membrane permeability. Of these, cyclosporin A is perhaps the most well-known example,…”
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Linking molecular evolution to molecular grafting by Wang, Conan K., Craik, David J.

“…Molecular grafting is a strategy for the engineering of molecular scaffolds into new functional agents, such as next-generation therapeutics. Despite its wide…”
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Sex-specific expression of pheromones and other signals in gravid starfish by Jönsson, Mathias, Morin, Marie, Wang, Conan K, Craik, David J, Degnan, Sandie M, Degnan, Bernard M

“…Many echinoderms form seasonal aggregations prior to spawning. In some fecund species, a spawning event can lead to population outbreaks with detrimental…”
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ConoServer, a database for conopeptide sequences and structures by Kaas, Quentin, Westermann, Jan-C., Halai, Reena, Wang, Conan K. L., Craik, David J.

“…ConoServer is a new database dedicated to conopeptides, a large family of peptides found in the venom of marine snails of the genus Conus. These peptides have…”
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Seasonal tissue-specific gene expression in wild crown-of-thorns starfish reveals reproductive and stress-related transcriptional systems by Morin, Marie, Jönsson, Mathias, Wang, Conan K, Craik, David J, Degnan, Sandie M, Degnan, Bernard M

“…Animals are influenced by the season, yet we know little about the changes that occur in most species throughout the year. This is particularly true in…”
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Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients by Wang, Conan K., Northfield, Susan E., Colless, Barbara, Chaousis, Stephanie, Hamernig, Ingrid, Lohman, Rink-Jan, Nielsen, Daniel S., Schroeder, Christina I., Liras, Spiros, Price, David A., Fairlie, David P., Craik, David J.

“…Significance Peptides are valuable leads for drug development, offering advantages over other molecular classes. Specifically, they can bind potently and…”
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Molecular Grafting onto a Stable Framework Yields Novel Cyclic Peptides for the Treatment of Multiple Sclerosis by Wang, Conan K, Gruber, Christian W, Cemazar, Maša, Siatskas, Christopher, Tagore, Prascilla, Payne, Natalie, Sun, Guizhi, Wang, Shunhe, Bernard, Claude C, Craik, David J

“…Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) and is characterized by the destruction of myelin and axons leading to…”
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Enabling Efficient Folding and High-Resolution Crystallographic Analysis of Bracelet Cyclotides by Huang, Yen-Hua, Du, Qingdan, Jiang, Zhihao, King, Gordon J, Collins, Brett M, Wang, Conan K, Craik, David J

“…Cyclotides have attracted great interest as drug design scaffolds because of their unique cyclic cystine knotted topology. They are classified into three…”
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Exploring experimental and computational markers of cyclic peptides: Charting islands of permeability by Wang, Conan K., Northfield, Susan E., Swedberg, Joakim E., Colless, Barbara, Chaousis, Stephanie, Price, David A., Liras, Spiros, Craik, David J.

“…An increasing number of macrocyclic peptides that cross biological membranes are being reported, suggesting that it might be possible to develop peptides into…”
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Using the MCoTI-II Cyclotide Scaffold To Design a Stable Cyclic Peptide Antagonist of SET, a Protein Overexpressed in Human Cancer by D’Souza, Charlotte, Henriques, Sónia Troeira, Wang, Conan K, Cheneval, Olivier, Chan, Lai Yue, Bokil, Nilesh J, Sweet, Matthew J, Craik, David J

“…The SET protein is a promising drug target in cancer therapy, because of its ability to inhibit the function of the tumor suppressor gene protein phosphatase…”
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Racemic and Quasi-Racemic X-ray Structures of Cyclic Disulfide-Rich Peptide Drug Scaffolds by Wang, Conan K., King, Gordon J., Northfield, Susan E., Ojeda, Paola G., Craik, David J.

“…Cyclic disulfide‐rich peptides have exceptional stability and are promising frameworks for drug design. We were interested in obtaining X‐ray structures of…”
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Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold by Huang, Yen-Hua, Henriques, Sónia T., Wang, Conan K., Thorstholm, Louise, Daly, Norelle L., Kaas, Quentin, Craik, David J.

“…The constitutively active tyrosine kinase BCR-ABL is the underlying cause of chronic myeloid leukemia (CML). Current CML treatments rely on the long-term use…”
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Structural parameters modulating the cellular uptake of disulfide-rich cyclic cell-penetrating peptides: MCoTI-II and SFTI-1 by D’Souza, Charlotte, Henriques, Sónia Troeira, Wang, Conan K., Craik, David J.

“…Peptides are emerging as a new class of therapeutics due to their high potency and specificity for a range of targets, including the inhibition of…”
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Anti-HIV Cyclotides from the Chinese Medicinal Herb Viola yedoensis by Wang, Conan K. L, Colgrave, Michelle L, Gustafson, Kirk R, Ireland, David C, Goransson, Ulf, Craik, David J

“…Cyclotides are macrocyclic plant peptides characterized by a knotted arrangement of three disulfide bonds. They display a range of interesting bioactivities,…”
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Distribution and Evolution of Circular Miniproteins in Flowering Plants by Gruber, Christian W, Elliott, Alysha G, Ireland, David C, Delprete, Piero G, Dessein, Steven, Göransson, Ulf, Trabi, Manuela, Wang, Conan K, Kinghorn, Andrew B, Robbrecht, Elmar, Craik, David J

“…Cyclotides are disulfide-rich miniproteins with the unique structural features of a circular backbone and knotted arrangement of three conserved disulfide…”
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CyBase: a database of cyclic protein sequences and structures, with applications in protein discovery and engineering by Wang, Conan K.L, Kaas, Quentin, Chiche, Laurent, Craik, David J

“…CyBase was originally developed as a database for backbone-cyclized proteins, providing search and display capabilities for sequence, structure and function…”
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Alanine Scanning Mutagenesis of the Prototypic Cyclotide Reveals a Cluster of Residues Essential for Bioactivity by Simonsen, Shane M., Sando, Lillian, Rosengren, K. Johan, Wang, Conan K., Colgrave, Michelle L., Daly, Norelle L., Craik, David J.

“…The cyclotides are stable plant-derived mini-proteins with a topologically circular peptide backbone and a knotted arrangement of three disulfide bonds that…”
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Designing macrocyclic disulfide-rich peptides for biotechnological applications by Wang, Conan K., Craik, David J.

“…Bioactive peptides have potential as drug leads, but turning them into drugs is a challenge because of their typically poor metabolic stability. Molecular…”
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