Search Results - "Wang, Chensu"

Enhanced CAR-T cell activity against solid tumors by vaccine boosting through the chimeric receptor by Ma, Leyuan, Dichwalkar, Tanmay, Chang, Jason Y H, Cossette, Benjamin, Garafola, Daniel, Zhang, Angela Q, Fichter, Michael, Wang, Chensu, Liang, Simon, Silva, Murillo, Kumari, Sudha, Mehta, Naveen K, Abraham, Wuhbet, Thai, Nikki, Li, Na, Wittrup, K Dane, Irvine, Darrell J

“…Chimeric antigen receptor-T cell (CAR-T) therapy has been effective in the treatment of hematologic malignancies, but it has shown limited efficacy against…”
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Molecular basis of cooperativity in pH-triggered supramolecular self-assembly by Li, Yang, Zhao, Tian, Wang, Chensu, Lin, Zhiqiang, Huang, Gang, Sumer, Baran D., Gao, Jinming

“…Supramolecular self-assembly offers a powerful strategy to produce high-performance, stimuli-responsive nanomaterials. However, lack of molecular understanding…”
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Gold Nanoclusters and Graphene Nanocomposites for Drug Delivery and Imaging of Cancer Cells by Wang, Chensu, Li, Jingyuan, Amatore, Christian, Chen, Yu, Jiang, Hui, Wang, Xue-Mei

“…Gold and carbon make it together: Gold nanoclusters (GNCs) impregnated onto reduced graphene oxide (RGO) nanosheets cross swiftly across HepG2 hepatocarcinoma…”
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Digitization of Endocytic pH by Hybrid Ultra‐pH‐Sensitive Nanoprobes at Single‐Organelle Resolution by Wang, Yiguang, Wang, Chensu, Li, Yang, Huang, Gang, Zhao, Tian, Ma, Xinpeng, Wang, Zhaohui, Sumer, Baran D., White, Michael A., Gao, Jinming

“…A multispectral hybrid nanotransistor consisting of modular fluorescent block copolymers with discrete and sharp pH transitions in one nanoparticluate system…”
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Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan by Wang, Chensu, Niederstrasser, Hanspeter, Douglas, Peter M., Lin, Rueyling, Jaramillo, Juan, Li, Yang, Oswald, Nathaniel W., Zhou, Anwu, McMillan, Elizabeth A., Mendiratta, Saurabh, Wang, Zhaohui, Zhao, Tian, Lin, Zhiqaing, Luo, Min, Huang, Gang, Brekken, Rolf A., Posner, Bruce A., MacMillan, John B., Gao, Jinming, White, Michael A.

“…Drugs that mirror the cellular effects of starvation mimics are considered promising therapeutics for common metabolic disorders, such as obesity, liver…”
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Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2 by Dutchak, Paul A., Laxman, Sunil, Estill, Sandi Jo, Wang, Chensu, Wang, Yun, Wang, Yiguang, Bulut, Gamze B., Gao, Jinming, Huang, Lily J., Tu, Benjamin P.

“…Nitrogen permease regulator-like 2 (NPRL2) is a component of a conserved complex that inhibits mTORC1 (mammalian Target Of Rapamycin Complex 1) in response to…”
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564 Single-cell transcriptomic analysis of immune compartments following combination immunotherapy treatment in poorly immunogenic tumors by Cui, Ang, Moynihan, Kelly, Li, Shuqiang, Wang, Chensu, Southard, Jackson, Hacohen, Nir, Irvine, Darrell

“…BackgroundA major goal in cancer immunology is to rationally design combination therapies that lead to a higher response rate, especially for poorly…”
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Machine learning and robot-assisted synthesis of diverse gold nanorods via seedless approach by Moses, Oyawale Adetunji, Adam, Mukhtar Lawan, Chen, Zijian, Ezeh, Collins Izuchukwu, Huang, Hao, Wang, Zhuo, Wang, Zixuan, Wang, Boyuan, Li, Wentao, Wang, Chensu, Yin, Zongyou, Lu, Yang, Yu, Xue-Feng, Zhao, Haitao

“…The challenge of data-driven synthesis of advanced nanomaterials can be minimized by using machine learning algorithms to optimize synthesis parameters and…”
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Integration of data-intensive, machine learning and robotic experimental approaches for accelerated discovery of catalysts in renewable energy-related reactions by Moses, Oyawale Adetunji, Chen, Wei, Adam, Mukhtar Lawan, Wang, Zhuo, Liu, Kaili, Shao, Junming, Li, Zhengsheng, Li, Wentao, Wang, Chensu, Zhao, Haitao, Pang, Cheng Heng, Yin, Zongyou, Yu, Xuefeng

“…Technological advancements in recent decades have greatly transformed the field of material chemistry. Juxtaposing the accentuating energy demand with the…”
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Erratum: Molecular basis of cooperativity in pH-triggered supramolecular self-assembly by Li, Yang, Zhao, Tian, Wang, Chensu, Lin, Zhiqiang, Huang, Gang, Sumer, Baran D., Gao, Jinming

“…Nature Communications 7: Article number: 13214 (2016); Published: 27 October 2016; Updated: 16 December 2016 Figure 5 of this article contained errors…”
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Author Correction: Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan by Wang, Chensu, Niederstrasser, Hanspeter, Douglas, Peter M., Lin, Rueyling, Jaramillo, Juan, Li, Yang, Oswald, Nathaniel W., Zhou, Anwu, McMillan, Elizabeth A., Mendiratta, Saurabh, Wang, Zhaohui, Zhao, Tian, Lin, Zhiqaing, Luo, Min, Huang, Gang, Brekken, Rolf A., Posner, Bruce A., MacMillan, John B., Gao, Jinming, White, Michael A.

“…The originally published version of this Article contained an error in the spelling of the author Nathaniel W. Oswald, which was incorrectly given as Nathaniel…”
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PET imaging of occult tumours by temporal integration of tumour-acidosis signals from pH-sensitive 64Cu-labelled polymers by Huang, Gang, Zhao, Tian, Wang, Chensu, Nham, Kien, Xiong, Yahong, Gao, Xiaofei, Wang, Yihui, Hao, Guiyang, Ge, Woo-Ping, Sun, Xiankai, Sumer, Baran D., Gao, Jinming

“…Owing to the diversity of cancer types and the spatiotemporal heterogeneity of tumour signals, high-resolution imaging of occult malignancy is challenging. 18…”
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Investigation of endosome and lysosome biology by ultra pH-sensitive nanoprobes by Wang, Chensu, Zhao, Tian, Li, Yang, Huang, Gang, White, Michael A., Gao, Jinming

“…Endosomes and lysosomes play a critical role in various aspects of cell physiology such as nutrient sensing, receptor recycling, protein/lipid catabolism, and…”
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Optical molecular imaging for tumor detection and image-guided surgery by Wang, Chensu, Wang, Zhaohui, Zhao, Tian, Li, Yang, Huang, Gang, Sumer, Baran D., Gao, Jinming

“…We have witnessed rapid development of fluorescence molecular imaging of solid tumors for cancer diagnosis and image-guided surgery in the past decade. Many…”
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A STING-activating nanovaccine for cancer immunotherapy by Luo, Min, Wang, Hua, Wang, Zhaohui, Cai, Haocheng, Lu, Zhigang, Li, Yang, Du, Mingjian, Huang, Gang, Wang, Chensu, Chen, Xiang, Porembka, Matthew R., Lea, Jayanthi, Frankel, Arthur E., Fu, Yang-Xin, Chen, Zhijian J., Gao, Jinming

“…STING-activating nanoparticle vaccines achieve robust activation of tumour-specific T cells for cancer immunotherapy. The generation of tumour-specific T cells…”
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Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade by Wang, Chensu, Cui, Ang, Bukenya, Maurice, Aung, Aereas, Pradhan, Dikshant, Whittaker, Charles A., Agarwal, Yash, Thomas, Ayush, Liang, Simon, Amlashi, Parastoo, Suh, Heikyung, Spranger, Stefani, Hacohen, Nir, Irvine, Darrell J.

“…Treatments aiming to augment immune checkpoint blockade (ICB) in cancer often focus on T cell immunity, but innate immune cells may have important roles to…”
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Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells by Rakhra, Kavya, Abraham, Wuhbet, Wang, Chensu, Moynihan, Kelly D, Li, Na, Donahue, Nathan, Baldeon, Alexis D, Irvine, Darrell J

“…Tissue-resident memory T cells (T ) can profoundly enhance mucosal immunity, but parameters governing T induction by vaccination remain poorly understood…”
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A nanobuffer reporter library for fine-scale imaging and perturbation of endocytic organelles by Wang, Chensu, Wang, Yiguang, Li, Yang, Bodemann, Brian, Zhao, Tian, Ma, Xinpeng, Huang, Gang, Hu, Zeping, DeBerardinis, Ralph J., White, Michael A., Gao, Jinming

“…Endosomes, lysosomes and related catabolic organelles are a dynamic continuum of vacuolar structures that impact a number of cell physiological processes such…”
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Exocyst protein subnetworks integrate Hippo and mTOR signaling to promote virus detection and cancer by Zaman, Aubhishek, Wu, Xiaofeng, Lemoff, Andrew, Yadavalli, Sivaramakrishna, Lee, Jeon, Wang, Chensu, Cooper, Jonathan, McMillan, Elizabeth A., Yeaman, Charles, Mirzaei, Hamid, White, Michael A., Bivona, Trever G.

“…The exocyst is an evolutionarily conserved protein complex that regulates vesicular trafficking and scaffolds signal transduction. Key upstream components of…”
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αPD-1 and extended half-life IL-2 combination therapy clears established GL261 gliomas in an MHC class I independent fashion by Tritz, Zachariah Peter, Ayasoufi, Kathy, Malo, Courtney Sarah, Himes, Benjamin, Khadka, Roman, Yokanovich, Lila T, Goddery, Emma, Fain, Cori, Hansen, Michael, Jin, Fang, Wang, Chensu, Moynihan, Kelly, Irvine, Darrell J, Wittrup, K Dane, Parney, Ian, Johnson, Aaron J

“…Abstract Glioblastoma multiforme (GBM) is a deadly CNS malignancy with an average survival of ~12 months post diagnosis despite aggressive treatment…”
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