Search Results - "Wang, Chengniu"
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Identification of functional farnesoid X receptors in brain neurons
Published in FEBS letters (01-09-2016)“…Farnesoid X receptor (FXR) has been confirmed to sense bile acids in various tissues. However, its expression in brain neurons remains obscure. In this study,…”
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2
microRNA-455 targets cullin 3 to activate Nrf2 signaling and protect human osteoblasts from hydrogen peroxide
Published in Oncotarget (29-08-2017)“…Over-production of hydrogen peroxide (H O ) will lead to human osteoblast dysfunction and apoptosis, causing progression of osteoporosis and osteonecrosis…”
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3
The antidepressant-like effects of fluvoxamine in mice involve the mTOR signaling in the hippocampus and prefrontal cortex
Published in Psychiatry research (01-03-2020)“…•Fluvoxamine treatment reversed the effects of CUMS on the hippocampal mTOR signaling.•Fluvoxamine treatment restored the effects of CUMS on mTOR in the…”
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4
Spatio-temporal landscape of mouse epididymal cells and specific mitochondria-rich segments defined by large-scale single-cell RNA-seq
Published in Cell discovery (18-05-2021)“…Spermatozoa acquire their fertilizing ability and forward motility during epididymal transit, suggesting the importance of the epididymis. Although the cell…”
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5
Isatin improves oligoasthenospermia caused by busulfan by regulating GSH/GPX4 axis to inhibit ferroptosis
Published in Frontiers in pharmacology (31-10-2024)“…Introduction Ferroptosis, induced by iron overload and an imbalance in redox homeostasis, promotes the generation of reactive oxygen species (ROS), leading to…”
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Peptides from the croceine croaker (Larimichthys crocea) swim bladder attenuate busulfan-induced oligoasthenospermia in mice
Published in Pharmaceutical biology (01-12-2022)“…The swim bladder of the croceine croaker is believed to have a therapeutic effect on various diseases. However, there is no research about its effect on…”
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The Selective SIK2 Inhibitor ARN-3236 Produces Strong Antidepressant-Like Efficacy in Mice via the Hippocampal CRTC1-CREB-BDNF Pathway
Published in Frontiers in pharmacology (14-01-2021)“…Depression is a widespread chronic medical illness affecting thoughts, mood, and physical health. However, the limited and delayed therapeutic efficacy of…”
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Neuroprotective Strategies for Stroke by Natural Products: Advances and Perspectives
Published in Current neuropharmacology (01-01-2023)“…Cerebral ischemic stroke is a disease with high prevalence and incidence. Its management focuses on rapid reperfusion with intravenous thrombolysis and…”
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Classifying Heart-Sound Signals Based on CNN Trained on MelSpectrum and Log-MelSpectrum Features
Published in Bioengineering (Basel) (25-05-2023)“…The intelligent classification of heart-sound signals can assist clinicians in the rapid diagnosis of cardiovascular diseases. Mel-frequency cepstral…”
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10
Single‑cell RNA sequencing analysis of human embryos from the late Carnegie to fetal development
Published in Cell & bioscience (12-09-2024)“…The cell development atlas of transition stage from late Carnegie to fetal development (7-9 weeks) remain unclear. It can be seen that the early period of…”
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Single-cell RNA sequencing analysis of the temporomandibular joint condyle in 3 and 4-month-old human embryos
Published in Cell & bioscience (19-07-2023)“…The temporomandibular joint (TMJ) is a complex joint consisting of the condyle, the temporal articular surface, and the articular disc. Functions such as…”
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Ligand-Promoted Iridium-Catalyzed Transfer Hydrogenation of Terminal Alkynes with Ethanol and Its Application
Published in ACS omega (01-10-2019)“…A ligand-promoted iridium-catalyzed transfer hydrogenation of terminal alkynes with ethanol and its application has been developed. Highly chemical selectivity…”
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13
Synthesis and Cytotoxicity Evaluation of Novel Podophyllotoxin Derivatives
Published in Archiv der Pharmazie (Weinheim) (01-11-2011)“…Seven benzylamino derivatives of podophyllotoxin 8a–8g were synthesized and their chemical structures were confirmed by IR, 1H‐NMR, 13C‐NMR and ESI‐MS spectral…”
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14
Inhibition of ferroptosis attenuates oligospermia in male Nrf2 knockout mice
Published in Free radical biology & medicine (20-11-2022)“…Nuclear factor-E2-related factor 2 (Nrf2) expression in sperm decreases in some oligospermia patients. However, the mechanism of reduced Nrf2 expression in…”
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Antidepressant-like effects of ginsenoside Rg5 in mice: Involving of hippocampus BDNF signaling pathway
Published in Neuroscience letters (03-04-2017)“…•Ginsenoside Rg5 has antidepressant-like effects in mice and may be developed as a new antidepressant.•Ginsenoside Rg5 has enhancing effects on the hippocampal…”
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Dopamine-Modified AuCu Bimetallic Nanoclusters as Charge Transfer-Based Biosensors for Highly Sensitive Glycine Detection
Published in Langmuir (24-11-2020)“…Glycine is the simplest amino acid in living organisms and plays important roles in biology and medicine. However, few biosensors for glycine sensing have been…”
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Hippocampal mTOR signaling is required for the antidepressant effects of paroxetine
Published in Neuropharmacology (01-01-2018)“…Although thought as a selective serotonin reuptake inhibitor (SSRI), the antidepressant mechanisms of paroxetine remain unknown. Previous studies have shown…”
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5- methylcytidine effectively improves spermatogenesis recovery in busulfan-induced oligoasthenospermia mice
Published in European journal of pharmacology (15-03-2024)“…The function and regulatory mechanisms of 5-methylcytidine (m5C) in oligoasthenospermia remain unclear. In this study, we made a mouse model of…”
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A hybrid ratiometric probe for the differential detection of testosterone and iron ions based on simultaneous response of fluorescence and light scattering of gold nanoclusters
Published in Inorganica Chimica Acta (24-05-2023)“…[Display omitted] •Constructed a hybrid ratiometric probe based on fluorescence and light scattering.•Achieved the differential detection of testosterone and…”
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Hypoxia-induced TRPM7 promotes glycolytic metabolism and progression in hepatocellular carcinoma
Published in European journal of pharmacology (05-07-2024)“…Hypoxia disrupts glucose metabolism in hepatocellular carcinoma (HCC). Transient receptor potential cation channel, subfamily M, member 7 (TRPM7) plays an…”
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