Search Results - "Wang, Changnan"
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Attenuation of Sepsis-Induced Acute Kidney Injury by Exogenous H2S via Inhibition of Ferroptosis
Published in Molecules (Basel, Switzerland) (14-06-2023)“…Sepsis-associated acute kidney injury (SA-AKI) results in significant morbidity and mortality, and ferroptosis may play a role in its pathogenesis. Our aim was…”
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2
Reduced hydrogen sulfide production contributes to adrenal insufficiency induced by hypoxia via modulation of NLRP3 inflammasome activation
Published in Redox report : communications in free radical research (31-12-2023)“…Objective: Adrenocortical responsiveness is critical for maintaining glucocorticoids production and homeostasis during stress. We sought to investigate…”
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Skeletal muscle cystathionine γ-lyase deficiency promotes obesity and insulin resistance and results in hyperglycemia and skeletal muscle injury upon HFD in mice
Published in Redox report : communications in free radical research (01-12-2024)“…The objective of this study was to investigate whether skeletal muscle cystathionine γ-lyase (CTH) contributes to high-fat diet (HFD)-induced metabolic…”
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4
LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans
Published in Cell reports (Cambridge) (26-03-2024)“…Insulin-mechanistic target of rapamycin (mTOR) signaling drives anabolic growth during organismal development; its late-life dysregulation contributes to aging…”
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A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience
Published in Nature communications (10-11-2022)“…Cells adapt to cold by increasing levels of unsaturated phospholipids and membrane fluidity through conserved homeostatic mechanisms. Here we report an…”
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Late Jurassic Wenjiaping high Sr/Y granite: A product of partial melting of the Precambrian basement rocks trigged by lithospheric extension in the Songpan–Garzê fold belt, SW China
Published in Geological journal (Chichester, England) (01-10-2022)“…The Wenjiaping granite, as one of the few Late Jurassic granites in the Songpan–Garzê fold belt (SGFB), can provide an important clue for comprehensively…”
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The C. elegans homolog of human panic-disorder risk gene TMEM132D orchestrates neuronal morphogenesis through the WAVE-regulatory complex
Published in Molecular brain (16-03-2021)“…TMEM132D is a human gene identified with multiple risk alleles for panic disorders, anxiety and major depressive disorders. Defining a conserved family of…”
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Pennsylvanian–early Permian palaeokarst development on the Yangtze Platform, South China, and implications for the regional sea‐level history
Published in Geological journal (Chichester, England) (01-07-2018)“…The Pennsylvanian to lower Permian succession at Madiyi, South China, represents a nearshore mixed siliciclastic‐carbonate system characterized by cyclic…”
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Endotoxin tolerance of adrenal gland: Attenuation of corticosterone production in response to lipopolysaccharide and adrenocorticotropic hormone
Published in Critical care medicine (01-03-2011)“…OBJECTIVES:Reversible adrenal insufficiency frequently has been diagnosed in critically ill patients with sepsis who have either low basal cortisol levels or…”
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10
Resveratrol alleviates acute lung injury through regulating PLSCR-3-mediated mitochondrial dysfunction and mitophagy in a cecal ligation and puncture model
Published in European journal of pharmacology (15-12-2021)“…Sepsis is considered as a life-threatening organ dysfunction caused by a dysregulated response of the host to an infection. Acute lung injury (ALI)/acute…”
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11
Attenuation of Sepsis-Induced Acute Kidney Injury by Exogenous H[sub.2]S via Inhibition of Ferroptosis
Published in Molecules (Basel, Switzerland) (01-06-2023)“…Sepsis-associated acute kidney injury (SA-AKI) results in significant morbidity and mortality, and ferroptosis may play a role in its pathogenesis. Our aim was…”
Get full text
Journal Article -
12
GPCR signaling regulates severe stress‐induced organismic death in Caenorhabditis elegans
Published in Aging cell (01-01-2023)“…How an organism dies is a fundamental yet poorly understood question in biology. An organism can die of many causes, including stress‐induced phenoptosis, also…”
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13
Endogenous H2S resists mitochondria-mediated apoptosis in the adrenal glands via ATP5A1 S-sulfhydration in male mice
Published in Molecular and cellular endocrinology (15-10-2018)“…In a previous study, we showed that endogenous hydrogen sulfide (H2S) plays a key role in the maintenance of intact adrenal cortex function via the protection…”
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14
" Yin-Yang philosophy" for the design of anticancer drug delivery nanoparticles
Published in Biomaterials translational (2024)“…Understanding the in vivo transport process provides guidelines for designing ideal nanoparticles (NPs) with higher efficacy and fewer off-target effects. Many…”
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Hydrogen Sulfide Is a Regulator of Hemoglobin Oxygen-Carrying Capacity via Controlling 2,3-BPG Production in Erythrocytes
Published in Oxidative medicine and cellular longevity (2021)“…Hydrogen sulfide (H2S) is naturally synthesized in a wide range of mammalian tissues. Whether H2S is involved in the regulation of erythrocyte functions…”
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Estrogens increase cystathionine-γ-lyase expression and decrease inflammation and oxidative stress in the myocardium of ovariectomized rats
Published in Menopause (New York, N.Y.) (01-10-2013)“…OBJECTIVEHydrogen sulfide (H2S), generated in the myocardium predominantly via cystathionine-γ-lyase (CSE), is cardioprotective. The objectives of the present…”
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17
Endogenous H 2 S resists mitochondria-mediated apoptosis in the adrenal glands via ATP5A1 S-sulfhydration in male mice
Published in Molecular and cellular endocrinology (15-10-2018)“…In a previous study, we showed that endogenous hydrogen sulfide (H S) plays a key role in the maintenance of intact adrenal cortex function via the protection…”
Get full text
Journal Article -
18
Attenuation of Sepsis-Induced Acute Kidney Injury by Exogenous H 2 S via Inhibition of Ferroptosis
Published in Molecules (Basel, Switzerland) (14-06-2023)“…Sepsis-associated acute kidney injury (SA-AKI) results in significant morbidity and mortality, and ferroptosis may play a role in its pathogenesis. Our aim was…”
Get full text
Journal Article