Search Results - "Wang, Cathy S"

Serum B-cell maturation antigen: a novel biomarker to predict outcomes for multiple myeloma patients by Ghermezi, Michael, Li, Mingjie, Vardanyan, Suzie, Harutyunyan, Nika Manik, Gottlieb, Jillian, Berenson, Ariana, Spektor, Tanya M, Andreu-Vieyra, Claudia, Petraki, Sophia, Sanchez, Eric, Udd, Kyle, Wang, Cathy S, Swift, Regina A, Chen, Haiming, Berenson, James R

“…B-cell maturation antigen is expressed on plasma cells. In this study, we have identified serum B-cell maturation antigen as a novel biomarker that can monitor…”
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Multiscale profiling of protease activity in cancer by Amini, Ava P., Kirkpatrick, Jesse D., Wang, Cathy S., Jaeger, Alex M., Su, Susan, Naranjo, Santiago, Zhong, Qian, Cabana, Christina M., Jacks, Tyler, Bhatia, Sangeeta N.

“…Diverse processes in cancer are mediated by enzymes, which most proximally exert their function through their activity. High-fidelity methods to profile enzyme…”
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Soluble B-Cell Maturation Antigen Mediates Tumor-Induced Immune Deficiency in Multiple Myeloma by Sanchez, Eric, Gillespie, Abigail, Tang, George, Ferros, Morgan, Harutyunyan, Nika Manik, Vardanyan, Suzie, Gottlieb, Jillian, Li, Mingjie, Wang, Cathy S, Chen, Haiming, Berenson, James R

“…Reduced uninvolved immunoglobulin (Ig) levels are a hallmark of multiple myeloma. We previously showed that B-cell maturation antigen (BCMA) is solubilized and…”
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Aging and matrix viscoelasticity affect multiscale tendon properties and tendon derived cell behavior by Freedman, Benjamin R, Knecht, Raphael S, Tinguely, Yann, Eskibozkurt, G. Ege, Wang, Cathy S., Mooney, David J

“…Aging is the largest risk factor for Achilles tendon associated disorders and rupture. Although Achilles tendon macroscale elastic properties are suggested to…”
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JAK1/2 pathway inhibition suppresses M2 polarization and overcomes resistance of myeloma to lenalidomide by reducing TRIB1, MUC1, CD44, CXCL12, and CXCR4 expression by Chen, Haiming, Li, Mingjie, Sanchez, Eric, Soof, Camilia M., Bujarski, Sean, Ng, Nicole, Cao, Jasmin, Hekmati, Tara, Zahab, Brian, Nosrati, Jason D., Wen, Mingxiang, Wang, Cathy S., Tang, George, Xu, Ning, Spektor, Tanya M., Berenson, James R.

“…Summary Monocytes polarize into pro‐inflammatory macrophage‐1 (M1) or alternative macrophage‐2 (M2) states with distinct phenotypes and physiological…”
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Serum B-cell maturation antigen is elevated in multiple myeloma and correlates with disease status and survival by Sanchez, Eric, Li, Mingjie, Kitto, Alex, Li, Jennifer, Wang, Cathy S., Kirk, Dylan T., Yellin, Ori, Nichols, Cydney M., Dreyer, Marissa P., Ahles, Cameryn P., Robinson, Austin, Madden, Erik, Waterman, Gabriel N., Swift, Regina A., Bonavida, Benjamin, Boccia, Ralph, Vescio, Robert A., Crowley, John, Chen, Haiming, Berenson, James R.

“…Summary Although TNFRSF17 (also designated as B‐cell maturation antigen (BCMA)) is expressed on tumour cells in B‐cell malignancies, it has not been found in…”
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Ruxolitinib reverses checkpoint inhibition by reducing programmed cell death ligand‐1 (PD‐L1) expression and increases anti‐tumour effects of T cells in multiple myeloma by Chen, Haiming, Li, Mingjie, Ng, Nicole, Yu, Erin, Bujarski, Sean, Yin, Zhengyi, Wen, Mingxiang, Hekmati, Tara, Field, Dylan, Wang, Jasper, Nassir, Isabella, Yu, Janna, Huang, Justin, Daniely, David, Wang, Cathy S., Xu, Ning, Spektor, Tanya M., Berenson, James R.

“…Summary Multiple myeloma (MM) tumour cells evade host immunity through a variety of mechanisms, which may potentially include the programmed cell death…”
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Serum B-cell maturation antigen (BCMA) reduces binding of anti-BCMA antibody to multiple myeloma cells by Chen, Haiming, Li, Mingjie, Xu, Ning, Ng, Nicole, Sanchez, Eric, Soof, Camilia M., Patil, Saurabh, Udd, Kyle, Bujarski, Sean, Cao, Jasmin, Hekmati, Tara, Ghermezi, Matthew, Zhou, Mizi, Wang, Emily Y., Tanenbaum, Edward J., Zahab, Brian, Schlossberg, Remy, Yashar, Moryel A., Wang, Cathy S., Tang, George Y., Spektor, Tanya M., Berenson, James R.

“…•Patients with BCMA ≥156 ng/mL have decreased anti-BCMA binding to MM tumor cells.•Circulating BCMA levels in the majority of RRMM patients are…”
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The JAK1/2 inhibitor ruxolitinib downregulates the immune checkpoint protein B7H3 in multiple myeloma by Xu, Ning, Yu, Erin, Ng, Nicole, Li, Mingjie, Bujarski, Sean, Hekmati, Ava, Nassir, Isabella, Hekmati, Tara, Yu, Janna, Daniely, David, Wang, Cathy S., Kim, Clara, Chen, Haiming, Berenson, James R.

“…We hypothesized that ruxolitinib may inhibit the immune checkpoint protein, B7H3; and, thus, investigated its effects on this immune inhibitor using multiple…”
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The clinical significance of B-cell maturation antigen as a therapeutic target and biomarker by Sanchez, Eric, Tanenbaum, Edward J, Patil, Saurabh, Li, Mingjie, Soof, Camilia M, Vidisheva, Aleksandra, Waterman, Gabriel N, Hekmati, Tara, Tang, George, Wang, Cathy S, Chen, Haiming, Berenson, James

“…B-cell maturation antigen (BCMA) is a cell membrane bound tumor necrosis factor receptor family member that is expressed exclusively on late stage normal and…”
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Anti-Angiogenic and Anti-Multiple Myeloma Effects of Oprozomib (OPZ) Alone and in Combination with Pomalidomide (Pom) and/or Dexamethasone (Dex) by Sanchez, Eric, Li, Mingjie, Wang, Cathy S, Tang, George, Gillespie, Abigail, Chen, Haiming, Berenson, James R

“…Highlights • Oprozomib (OPZ) shows anti-tumor activity in human multiple myeloma (MM) xenograft models • OPZ is an oral proteasome inhibitor that shows…”
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Combined TRAF6 Targeting and Proteasome Blockade Has Anti-myeloma and Anti-Bone Resorptive Effects by Chen, Haiming, Li, Mingjie, Sanchez, Eric, Wang, Cathy S, Lee, Tiffany, Soof, Camilia M, Casas, Christian E, Cao, Jasmin, Xie, Colin, Udd, Kyle A, DeCorso, Kevin, Tang, George Y, Spektor, Tanya M, Berenson, James R

“…TNF receptor-associated factor 6 (TRAF6) has been implicated in polyubiquitin-mediated IL1R/TLR signaling through activation of kinase (IKK) to regulate the…”
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Protease Activity Analysis: A Toolkit for Analyzing Enzyme Activity Data by Soleimany, Ava P., Martin-Alonso, Carmen, Anahtar, Melodi, Wang, Cathy S., Bhatia, Sangeeta N.

“…Analyzing the activity of proteases and their substrates is critical to defining the biological functions of these enzymes and to designing new diagnostics and…”
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The Role of B-Cell Maturation Antigen in the Biology and Management of, and as a Potential Therapeutic Target in, Multiple Myeloma by Sanchez, Eric, Smith, Emily J., Yashar, Moryel A., Patil, Saurabh, Li, Mingjie, Porter, Autumn L., Tanenbaum, Edward J., Schlossberg, Remy E., Soof, Camilia M., Hekmati, Tara, Tang, George, Wang, Cathy S., Chen, Haiming, Berenson, James R.

“…B-cell maturation antigen (BCMA) was originally identified as a cell membrane receptor, expressed exclusively on late stage B-cells and plasma cells (PCs)…”
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Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis by Chen, Haiming, Campbell, Richard A., Chang, Yunchao, Li, Mingjie, Wang, Cathy S., Li, Jennifer, Sanchez, Eric, Share, Michael, Steinberg, Jeffrey, Berenson, Ariana, Shalitin, Dror, Zeng, Zhaohui, Gui, Dorina, Perez-Pinera, Pablo, Berenson, Ronald J., Said, Jonathan, Bonavida, Benjamin, Deuel, Thomas F., Berenson, James R.

“…Enhanced angiogenesis is a hallmark of cancer. Pleiotrophin (PTN) is an angiogenic factor that is produced by many different human cancers and stimulates tumor…”
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A novel angiogenesis model for screening anti-angiogenic compounds: The chorioallantoic membrane/feather bud assay by HAIMING CHEN, WANG, Cathy S, BONAVIDA, Benjamin, BERENSON, James R, MINGJIE LI, SANCHEZ, Eric, LI, Jennifer, BERENSON, Ariana, WIRTSCHAFTER, Eric, WANG, James, JING SHEN, ZHIWEI LI

“…Enhanced angiogenesis is a hallmark of solid tumors and hematological malignancies. Anti-angiogenic therapeutic approaches have recently been shown to be…”
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Pleiotrophin is highly expressed by myeloma cells and promotes myeloma tumor growth by Chen, Haiming, Gordon, Melinda S., Campbell, Richard A., Li, Mingjie, Wang, Cathy S., Lee, Hee Jin, Sanchez, Eric, Manyak, Steven J., Gui, Dorina, Shalitin, Dror, Said, Jonathan, Chang, Yunchao, Deuel, Thomas F., Baritaki, Stavroula, Bonavida, Benjamin, Berenson, James R.

“…Pleiotrophin (PTN) is an important developmental cytokine that is highly expressed during embryogenesis but shows very limited expression in adult tissues,…”
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Effects of INCB052793, a Selective JAK1 Inhibitor, in Combination with Anti-Myeloma Agents on Human Multiple Myeloma (MM) In Vitro and In Vivo by Sanchez, Eric, Li, Mingjie, Wang, Cathy S, Mehta, Puja, Tang, George, Chen, Haiming, Berenson, James

“…Introduction: Several studies have demonstrated constitutive activation of the JAK-STAT pathway in MM through dysregulated signaling of cytokines such as IL-6…”
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Baseline and Early Changes in Serum B-Cell Maturation Antigen Levels Predict Progression Free Survival and Response Status for Multiple Myeloma Patients in a Phase 1 Trial Evaluating Ruxolitinib, Lenalidomide and Methylprednisolone by Bujarski, Sean, Soof, Camilia, Li, Mingjie, Wang, Cathy S., Sanchez, Eric, Emamy-Sadr, Marsiye, Swift, Regina, Rahbari, Kian, Patil, Saurabh, Spektor, Tanya M., Chen, Haiming, Berenson, James R.

“…Background: B-cell maturation antigen (BCMA) is highly expressed on malignant plasma cells from patients with multiple myeloma (MM). We have previously shown…”
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Baseline and Increases in Serum B-Cell Maturation Antigen Levels Rapidly Indicate Changes in Clinical Status Among Relapsed/Refractory Multiple Myeloma Patients Undergoing New Treatments by Bujarski, Sean, Udd, Kyle, Soof, Camilia, Spektor, Tanya M., Safaie, Tahmineh, Chen, Haiming, Li, Mingjie, Sanchez, Eric, Stern, Joshua, Wang, Cathy S., Xu, Ning, Emamy-Sadr, Marsiye, Swift, Regina, Rahbari, Ashkon, Patil, Saurabh, Souther, Eric, Berenson, James R.

“…Introduction: B-cell maturation antigen (BCMA) is a protein that is expressed on malignant plasma cells from patients (pts) with multiple myeloma (MM). Our…”
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