Search Results - "Wang, Amber W"

Collapse of the hepatic gene regulatory network in the absence of FoxA factors by Reizel, Yitzhak, Morgan, Ashleigh, Gao, Long, Lan, Yemin, Manduchi, Elisabetta, Waite, Eric L, Wang, Amber W, Wells, Andrew, Kaestner, Klaus H

“…The FoxA transcription factors are critical for liver development through their pioneering activity, which initiates a highly complex regulatory network…”
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Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues by Kapoor, Varun N., Müller, Sören, Keerthivasan, Shilpa, Brown, Markus, Chalouni, Cecile, Storm, Elaine E., Castiglioni, Alessandra, Lane, Ryan, Nitschke, Maximilian, Dominguez, Claudia X., Astarita, Jillian L., Krishnamurty, Akshay T., Carbone, Catherine B., Senbabaoglu, Yasin, Wang, Amber W., Wu, Xiumin, Cremasco, Viviana, Roose-Girma, Merone, Tam, Lucinda, Doerr, Jonas, Chen, Mark Z., Lee, Wyne P., Modrusan, Zora, Yang, Yeqing Angela, Bourgon, Richard, Sandoval, Wendy, Shaw, Andrey S., de Sauvage, Frederic J., Mellman, Ira, Moussion, Christine, Turley, Shannon J.

“…Fibroblastic reticular cells (FRCs) are specialized stromal cells that define tissue architecture and regulate lymphocyte compartmentalization, homeostasis,…”
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Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors by Castiglioni, Alessandra, Yang, Yagai, Williams, Katherine, Gogineni, Alvin, Lane, Ryan S., Wang, Amber W., Shyer, Justin A., Zhang, Zhe, Mittman, Stephanie, Gutierrez, Alan, Astarita, Jillian L., Thai, Minh, Hung, Jeffrey, Yang, Yeqing Angela, Pourmohamad, Tony, Himmels, Patricia, De Simone, Marco, Elstrott, Justin, Capietto, Aude-Hélène, Cubas, Rafael, Modrusan, Zora, Sandoval, Wendy, Ziai, James, Gould, Stephen E., Fu, Wenxian, Wang, Yulei, Koerber, James T., Sanjabi, Shomyseh, Mellman, Ira, Turley, Shannon J., Müller, Sören

“…TGFβ signaling is associated with non-response to immune checkpoint blockade in patients with advanced cancers, particularly in the immune-excluded phenotype…”
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Cross-tissue organization of the fibroblast lineage by Buechler, Matthew B., Pradhan, Rachana N., Krishnamurty, Akshay T., Cox, Christian, Calviello, Aslihan Karabacak, Wang, Amber W., Yang, Yeqing Angela, Tam, Lucinda, Caothien, Roger, Roose-Girma, Merone, Modrusan, Zora, Arron, Joseph R., Bourgon, Richard, Müller, Sören, Turley, Shannon. J.

“…Fibroblasts are non-haematopoietic structural cells that define the architecture of organs, support the homeostasis of tissue-resident cells and have key roles…”
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LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity by Krishnamurty, Akshay T., Shyer, Justin A., Thai, Minh, Gandham, Vineela, Buechler, Matthew B., Yang, Yeqing Angela, Pradhan, Rachana N., Wang, Amber W., Sanchez, Patricia L., Qu, Yan, Breart, Beatrice, Chalouni, Cécile, Dunlap, Debra, Ziai, James, Elstrott, Justin, Zacharias, Neelie, Mao, Weiguang, Rowntree, Rebecca K., Sadowsky, Jack, Lewis, Gail D., Pillow, Thomas H., Nabet, Barzin Y., Banchereau, Romain, Tam, Lucinda, Caothien, Roger, Bacarro, Natasha, Roose-Girma, Merone, Modrusan, Zora, Mariathasan, Sanjeev, Müller, Sören, Turley, Shannon J.

“…Recent single-cell studies of cancer in both mice and humans have identified the emergence of a myofibroblast population specifically marked by the highly…”
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Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform by Wangensteen, Kirk J., Wang, Yue J., Dou, Zhixun, Wang, Amber W., Mosleh‐Shirazi, Elham, Horlbeck, Max A., Gilbert, Luke A., Weissman, Jonathan S., Berger, Shelley L., Kaestner, Klaus H.

“…Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated 9 activation (CRISPRa) systems have enabled genetic screens in cultured…”
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Targeted demethylation at the CDKN1C/p57 locus induces human β cell replication by Ou, Kristy, Yu, Ming, Moss, Nicholas G, Wang, Yue J, Wang, Amber W, Nguyen, Son C, Jiang, Connie, Feleke, Eseye, Kameswaran, Vasumathi, Joyce, Eric F, Naji, Ali, Glaser, Benjamin, Avrahami, Dana, Kaestner, Klaus H

“…The loss of insulin-secreting β cells is characteristic among type I and type II diabetes. Stimulating proliferation to expand sources of β cells for…”
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TRAP-seq identifies cystine/glutamate antiporter as a driver of recovery from liver injury by Wang, Amber W, Wangensteen, Kirk J, Wang, Yue J, Zahm, Adam M, Moss, Nicholas G, Erez, Noam, Kaestner, Klaus H

“…Understanding the molecular basis of the regenerative response following hepatic injury holds promise for improved treatment of liver diseases. Here, we report…”
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A High-Content Screen Identifies MicroRNAs That Regulate Liver Repopulation After Injury in Mice by Zahm, Adam M., Wang, Amber W., Wang, Yue J., Schug, Jonathan, Wangensteen, Kirk J., Kaestner, Klaus H.

“…Liver regeneration is impaired in mice with hepatocyte-specific deficiencies in microRNA (miRNA) processing, but it is not clear which miRNAs regulate this…”
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The Dynamic Chromatin Architecture of the Regenerating Liver by Wang, Amber W., Wang, Yue J., Zahm, Adam M., Morgan, Ashleigh R., Wangensteen, Kirk J., Kaestner, Klaus H.

“…The adult liver is the main detoxification organ and routinely is exposed to environmental insults but retains the ability to restore its mass and function…”
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Cell Type-specific Gene Expression Profiling in the Mouse Liver by Wang, Amber W, Zahm, Adam M, Wangensteen, Kirk J

“…Liver repopulation after injury is a crucial feature of mammals which prevents immediate organ failure and death after exposure of environmental toxins. A…”
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Omic association studies with R and bioconductor: Juan R.Gonzalez and AlejandroCaceresBoca Raton, FL: Chapman and Hall/CRC, 2020. pp. 390 by Wang, Amber W.

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Abstract P015: Biomarker results supporting selection of RP2D from a phase 1b study of ORIC-101, a glucocorticoid receptor antagonist, in combination with enzalutamide in patients with metastatic prostate cancer progressing on enzalutamide by Daemen, Anneleen, Barkund, Shravani, Johnson, Ann, Pankov, Aleksandr, Wang, Amber W., Zhou, Haiying, Multani, Pratik S., Maneval, Edna Chow, Friedman, Lori S., Patel, Rupal

“…Abstract Background: Preclinical studies have shown that activation of the glucocorticoid receptor (GR) leads to resistance to antiandrogens, which is reversed…”
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Gremlin 1.sup.+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues by Kapoor, Varun N, Müller, Sören, Keerthivasan, Shilpa, Brown, Markus, Chalouni, Cecile, Storm, Elaine E, Castiglioni, Alessandra, Lane, Ryan, Nitschke, Maximilian, Dominguez, Claudia X, Astarita, Jillian L, Krishnamurty, Akshay T, Senbabaoglu, Yasin, Wang, Amber W, Wu, Xiumin, Cremasco, Viviana, Roose-Girma, Merone

“…Fibroblastic reticular cells (FRCs) are specialized stromal cells that define tissue architecture and regulate lymphocyte compartmentalization, homeostasis,…”
Get full text

Targeted demethylation at the CDKN1C/p57 locus induces human cell replication by Ou, Kristy, Yu, Ming, Moss, Nicholas G, Wang, Yue J, Wang, Amber W, Nguyen, Son C, Jiang, Connie, Feleke, Eseye, Kameswaran, Vasumathi, Joyce, Eric F, Naji, Ali, Glaser, Benjamin, Avrahami, Dana, Kaestner, Klaus H

“…The loss of insulin-secreting [beta] cells is characteristic among type I and type II diabetes. Stimulating proliferation to expand sources of [beta] cells for…”
Get full text

Combinatorial genetics in liver repopulation and carcinogenesis with a novel in vivo CRISPR activation platform by Wangensteen, Kirk J., Wang, Yue J., Dou, Zhixun, Wang, Amber W., Mosleh-Shirazi, Elham, Horlbeck, Max A., Gilbert, Luke A., Weissman, Jonathan S., Berger, Shelley L., Kaestner, Klaus H.

“…CRISPR/Cas9 activation (CRISPRa) systems have enabled genetic screens in cultured cells lines to discover and characterize drivers and inhibitors of cancer…”
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The Dynamic Chromatin Architecture of the Regenerating LiverSummary by Amber W. Wang, Yue J. Wang, Adam M. Zahm, Ashleigh R. Morgan, Kirk J. Wangensteen, Klaus H. Kaestner

“…Background & Aims: The adult liver is the main detoxification organ and routinely is exposed to environmental insults but retains the ability to restore its…”
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Omic association studies with R and bioconductor: Juan R. Gonzalez and Alejandro Caceres Boca Raton, FL: Chapman and Hall/CRC, 2020. pp. 390 by Wang, Amber W.

Get full text