Search Results - "Wang, Adrienne M."

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation by Wang, Adrienne M, Miyata, Yoshinari, Klinedinst, Susan, Peng, Hwei-Ming, Chua, Jason P, Komiyama, Tomoko, Li, Xiaokai, Morishima, Yoshihiro, Merry, Diane E, Pratt, William B, Osawa, Yoichi, Collins, Catherine A, Gestwicki, Jason E, Lieberman, Andrew P

“…An allosteric activator of Hsp70 mimics Hip and reduces neurotoxicity in a model for spinobulbar muscular atrophy by promoting ubiquitination and degradation…”
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Macroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice by Yu, Zhigang, Wang, Adrienne M, Adachi, Hiroaki, Katsuno, Masahisa, Sobue, Gen, Yue, Zhenyu, Robins, Diane M, Lieberman, Andrew P

“…Altered protein homeostasis underlies degenerative diseases triggered by misfolded proteins, including spinal and bulbar muscular atrophy (SBMA), a…”
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Inhibition of Hsp70 by Methylene Blue Affects Signaling Protein Function and Ubiquitination and Modulates Polyglutamine Protein Degradation by Wang, Adrienne M., Morishima, Yoshihiro, Clapp, Kelly M., Peng, Hwei-Ming, Pratt, William B., Gestwicki, Jason E., Osawa, Yoichi, Lieberman, Andrew P.

“…The Hsp90/Hsp70-based chaperone machinery regulates the activity and degradation of many signaling proteins. Cycling with Hsp90 stabilizes client proteins,…”
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Fertile Waters for Aging Research by Wang, Adrienne M., Promislow, Daniel E.L., Kaeberlein, Matt

“…The quest to slow aging has come far, and what used to be the domain of science fiction writers and snake oil salesmen may soon become science fact. Innovative…”
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A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer by Burman, Jonathon L, Itsara, Leslie S, Kayser, Ernst-Bernhard, Suthammarak, Wichit, Wang, Adrienne M, Kaeberlein, Matt, Sedensky, Margaret M, Morgan, Philip G, Pallanck, Leo J

“…Mutations affecting mitochondrial complex I, a multi-subunit assembly that couples electron transfer to proton pumping, are the most frequent cause of…”
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pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast by Murakami, Christopher, Delaney, Joe R., Chou, Annie, Carr, Daniel, Schleit, Jennifer, Sutphin, George L., An, Elroy H., Castanza, Anthony S., Fletcher, Marissa, Goswami, Sarani, Higgins, Sean, Holmberg, Mollie, Hui, Jessica, Jelic, Monika, Jeong, Ki-Soo, Kim, Jin R., Klum, Shannon, Liao, Eric, Lin, Michael S., Lo, Winston, Miller, Hillary, Moller, Richard, Peng, Zhao J., Pollard, Tom, Pradeep, Prarthana, Pruett, Dillon, Rai, Dilreet, Ros, Vanessa, Schuster, Alex, Singh, Minnie, Spector, Benjamin L., Vander Wende, Helen, Wang, Adrienne M., Wasko, Brian M., Olsen, Brady, Kaeberlein, Matt

“…Chronological and replicative aging have been studied in yeast as alternative paradigms for post-mitotic and mitotic aging, respectively. It has been known for…”
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Biochemical Genetic Pathways that Modulate Aging in Multiple Species by Bitto, Alessandro, Wang, Adrienne M, Bennett, Christopher F, Kaeberlein, Matt

“…The mechanisms underlying biological aging have been extensively studied in the past 20 years with the avail of mainly four model organisms: the budding yeast…”
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Altered RNA splicing contributes to skeletal muscle pathology in Kennedy disease knock-in mice by Yu, Zhigang, Wang, Adrienne M, Robins, Diane M, Lieberman, Andrew P

“…Here, we used a mouse model of Kennedy disease, a degenerative disorder caused by an expanded CAG repeat in the androgen receptor (AR) gene, to explore…”
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Assessing the impact of comparative genomic sequence data on the functional annotation of the Drosophilagenome by Bergman, Casey M, Pfeiffer, Barret D, Rincón-Limas, Diego E, Hoskins, Roger A, Gnirke, Andreas, Mungall, Chris J, Wang, Adrienne M, Kronmiller, Brent, Pacleb, Joanne, Park, Soo, Stapleton, Mark, Wan, Kenneth, George, Reed A, de Jong, Pieter J, Botas, Juan, Rubin, Gerald M, Celniker, Susan E

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Using Drosophila to identify naturally occurring genetic modifiers of amyloid beta 42- and tau-induced toxicity by Yang, Ming, Zinkgraf, Matthew, Fitzgerald-Cook, Cecilia, Harrison, Benjamin R, Putzier, Alexandra, Promislow, Daniel E L, Wang, Adrienne M

“…Abstract Alzheimer's disease is characterized by 2 pathological proteins, amyloid beta 42 and tau. The majority of Alzheimer's disease cases in the population…”
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CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins by Morishima, Yoshihiro, Wang, Adrienne M., Yu, Zhigang, Pratt, William B., Osawa, Yoichi, Lieberman, Andrew P.

“…CHIP (carboxy terminus of Hsc70-interacting protein) an E3 ubiquitin ligase that binds to Hsp70 and Hsp90, promotes degradation of several Hsp90-regulated…”
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Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae by Delaney, Joe R., Murakami, Christopher, Chou, Annie, Carr, Daniel, Schleit, Jennifer, Sutphin, George L., An, Elroy H., Castanza, Anthony S., Fletcher, Marissa, Goswami, Sarani, Higgins, Sean, Holmberg, Mollie, Hui, Jessica, Jelic, Monika, Jeong, Ki-Soo, Kim, Jin R., Klum, Shannon, Liao, Eric, Lin, Michael S., Lo, Winston, Miller, Hillary, Moller, Richard, Peng, Zhao J., Pollard, Tom, Pradeep, Prarthana, Pruett, Dillon, Rai, Dilreet, Ros, Vanessa, Schuster, Alex, Singh, Minnie, Spector, Benjamin L., Wende, Helen Vander, Wang, Adrienne M., Wasko, Brian M., Olsen, Brady, Kaeberlein, Matt

“…Chronological aging of budding yeast cells results in a reduction in subsequent replicative life span through unknown mechanisms. Here we show that dietary…”
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End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging by Delaney, Joe R., Chou, Annie, Olsen, Brady, Carr, Daniel, Murakami, Christopher, Ahmed, Umema, Sim, Sylvia, An, Elroy H., Castanza, Anthony S., Fletcher, Marissa, Higgins, Sean, Holmberg, Mollie, Hui, Jessica, Jelic, Monika, Jeong, Ki-Soo, Kim, Jin R., Klum, Shannon, Liao, Eric, Lin, Michael S., Lo, Winston, Miller, Hillary, Moller, Richard, Peng, Zhao J., Pollard, Tom, Pradeep, Prarthana, Pruett, Dillon, Rai, Dilreet, Ros, Vanessa, Schleit, Jennifer, Schuster, Alex, Singh, Minnie, Spector, Benjamin L., Sutphin, George L., Wang, Adrienne M., Wasko, Brian M., Vander Wende, Helen, Kennedy, Brian K., Kaeberlein, Matt

“…Abstract There is growing evidence that stochastic events play an important role in determining individual longevity. Studies in model organisms have…”
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A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging by McCormick, Mark A., Delaney, Joe R., Tsuchiya, Mitsuhiro, Tsuchiyama, Scott, Shemorry, Anna, Sim, Sylvia, Chou, Annie Chia-Zong, Ahmed, Umema, Carr, Daniel, Murakami, Christopher J., Schleit, Jennifer, Sutphin, George L., Wasko, Brian M., Bennett, Christopher F., Wang, Adrienne M., Olsen, Brady, Beyer, Richard P., Bammler, Theodor K., Prunkard, Donna, Johnson, Simon C., Pennypacker, Juniper K., An, Elroy, Anies, Arieanna, Castanza, Anthony S., Choi, Eunice, Dang, Nick, Enerio, Shiena, Fletcher, Marissa, Fox, Lindsay, Goswami, Sarani, Higgins, Sean A., Holmberg, Molly A., Hu, Di, Hui, Jessica, Jelic, Monika, Jeong, Ki-Soo, Johnston, Elijah, Kerr, Emily O., Kim, Jin, Kim, Diana, Kirkland, Katie, Klum, Shannon, Kotireddy, Soumya, Liao, Eric, Lim, Michael, Lin, Michael S., Lo, Winston C., Lockshon, Dan, Miller, Hillary A., Moller, Richard M., Muller, Brian, Oakes, Jonathan, Pak, Diana N., Peng, Zhao Jun, Pham, Kim M., Pollard, Tom G., Pradeep, Prarthana, Pruett, Dillon, Rai, Dilreet, Robison, Brett, Rodriguez, Ariana A., Ros, Bopharoth, Sage, Michael, Singh, Manpreet K., Smith, Erica D., Snead, Katie, Solanky, Amrita, Spector, Benjamin L., Steffen, Kristan K., Tchao, Bie Nga, Ting, Marc K., Vander Wende, Helen, Wang, Dennis, Welton, K. Linnea, Westman, Eric A., Brem, Rachel B., Liu, Xin-guang, Suh, Yousin, Zhou, Zhongjun, Kaeberlein, Matt, Kennedy, Brian K.

“…Many genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces cerevisiae also affect aging in other organisms such as C. elegans and…”
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Abstract CT189: Patient-specific dendritic cell vaccines with tumor antigens from self-renewing autologous tumor cells in the treatment of primary advanced ovarian cancer: A multi-institutional phase II clinical trial by Abaid, Lisa N., Corr, Bradley R., Mason, James R., Friedman, Richard L., Eskander, Ramez N., Hsieh, Candace, Langford, Chris J., Carta, Krystal, Wang, Adrienne M., Langford, James A., Nistor, Gabriel I., Dillman, Robert O.

“…Abstract Standard treatment of primary ovarian epithelial cancer has improved, but 5-year survival is only about 40% for the cohort of patients who present…”
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Abstract CT182: Adjunctive treatment of primary glioblastoma with patient-specific dendritic cell vaccines pulsed with antigens from self-renewing autologous tumor cells: A phase II trial by Bota, Daniella A., Duma, Christopher M., Kesari, Santosh, Piccioni, David E., LaRocca, Renato V., O'Donnell, Robert T., Aiken, Robert D., Carrillo, Jose A., Hsieh, Candace, Langford, Chris J., Carta, Krystal, Wang, Adrienne M., Langford, James A., Taylor, Thomas H., Nistor, Gabriel I., Dillman, Robert O.

“…Abstract Standard treatment of primary glioblastoma (GBM) is associated with poor survival. Adjunctive therapy with patient-specific vaccines may improve…”
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Biochemical Genetic Pathways that Modulate Aging in Multiple Species: Figure 1 by Bitto, Alessandro, Wang, Adrienne M., Bennett, Christopher F., Kaeberlein, Matt

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Macroautophagy Is Regulated by the UPR-Mediator CHOP and Accentuates the Phenotype of SBMA Mice: e1002321 by Yu, Zhigang, Wang, Adrienne M, Adachi, Hiroaki, Katsuno, Masahisa, Sobue, Gen, Yue, Zhenyu, Robins, Diane M, Lieberman, Andrew P

“…Altered protein homeostasis underlies degenerative diseases triggered by misfolded proteins, including spinal and bulbar muscular atrophy (SBMA), a…”
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Targeting Protein Quality Control Pathways in Spinal and Bulbar Muscular Atrophy by Wang, Adrienne M

“…Spinal and bulbar muscular atrophy (SBMA) is a progressive neurodegenerative disease caused by a CAG/glutamine expansion in the androgen receptor (AR). Like…”
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Assessing the impact of comparative genomic sequence data on the functional annotation of the Drosophila genome by Bergman, Casey M, Pfeiffer, Barret D, Rincón-Limas, Diego E, Hoskins, Roger A, Gnirke, Andreas, Mungall, Chris J, Wang, Adrienne M, Kronmiller, Brent, Pacleb, Joanne, Park, Soo, Stapleton, Mark, Wan, Kenneth, George, Reed A, de Jong, Pieter J, Botas, Juan, Rubin, Gerald M, Celniker, Susan E

“…It is widely accepted that comparative sequence data can aid the functional annotation of genome sequences; however, the most informative species and features…”
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