Search Results - "Wanderley, Almir G."
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Evaluation of gastroprotective and ulcer healing activities of yellow mombin juice from Spondias mombin L
Published in PloS one (05-11-2018)“…Spondias mombin L. (yellow mombin) is a tree with a nutritional fruit that is commonly consumed in the North and Northeast of Brazil, as the juice of its pulp…”
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Synthesis of 1,2,3-triazole derivatives and in vitro antifungal evaluation on Candida strains
Published in Molecules (Basel, Switzerland) (16-05-2012)“…1,2,3-Triazoles have been extensively studied as compounds possessing important biological activities. In this work, we describe the synthesis of ten…”
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Hepatoprotective effect of the aqueous extract of Simarouba amara Aublet (Simaroubaceae) stem bark against carbon tetrachloride (CCl4)-induced hepatic damage in rats
Published in Molecules (Basel, Switzerland) (31-10-2014)“…Simarouba amara stem bark decoction has been traditionally used in Brazil to treat malaria, inflammation, fever, abdominal pain, diarrhea, wounds and as a…”
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Comparative computational studies of 3,4-dihydro-2,6-diaryl-4-oxo-pyrimidine-5-carbonitrile derivatives as potential antinociceptive agents
Published in Molecules (Basel, Switzerland) (16-01-2012)“…In this study, the antinociceptive properties of 3,4-dihydro-2,6-diaryl-4-oxo-pyrimidine-5-carbonitrile derivatives 5a-i at doses of 25 and 50 mg/kg were…”
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Toxicological studies on hydroalcohol extract of Calendula officinalis L
Published in Phytotherapy research (01-04-2007)“…The hydroalcohol extract (HAE) of Calendula officinalis L. was evaluated for its acute toxicity by the oral route in rats and mice and for the subacute effect…”
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Hybrid systems of glibenclamide and layered double hydroxides for solubility enhancement for the treatment of diabetes mellitus II
Published in Applied clay science (15-11-2019)“…The present research aimed at the synthesis of two new systems containing glibenclamide (GLIB) and double layered hydroxides (LDH). GLIB is an important drug…”
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Maternal protein restriction increases respiratory and sympathetic activities and sensitizes peripheral chemoreflex in male rat offspring
Published in The Journal of nutrition (01-05-2015)“…Maternal protein restriction in rats increases the risk of adult offspring arterial hypertension through unknown mechanisms. The aims of the study were to…”
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Maternal consumption of ɷ3 attenuates metabolic disruption elicited by saturated fatty acids-enriched diet in offspring rats
Published in Nutrition, metabolism, and cardiovascular diseases (01-01-2022)“…High-fat diet (HFD) intake during gestation and lactation has been associated with an increased risk of developing cardiometabolic disorders in adult…”
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Acute and subacute toxicity of Cassia occidentalis L. stem and leaf in Wistar rats
Published in Journal of ethnopharmacology (22-06-2011)“…Cassia occidentalis L. (syn. Senna occidentalis; Leguminosae) has been used as natural medicine in rainforests and tropical regions as laxative, analgesic,…”
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Antioxidant and Antiulcerogenic Activity of the Dry Extract of Pods of Libidibia ferrea Mart. ex Tul. (Fabaceae)
Published in Oxidative medicine and cellular longevity (2019)“…Ethnomedicinal studies in the Amazon community and in the Northeast region of Brazil highlight the use of Libidibia ferrea fruits for the treatment of gastric…”
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Development of Lapachol Topical Formulation: Anti-inflammatory Study of a Selected Formulation
Published in AAPS PharmSciTech (2008)“…This study aimed at developing a topical formulation of lapachol, a compound isolated from various Bignoniaceae species and at evaluating its topical…”
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Reproductive assessment of hydroalcohol extract of Calendula officinalis L. in Wistar rats
Published in Phytotherapy research (01-10-2009)“…The present study was conducted to evaluate the effects of the administration of a hydroalcohol extract of Calendula officinalis L. flowers (HAE) on the…”
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Synthesis, anti-inflammatory and antimicrobial activities of new 1,2,4-oxadiazoles peptidomimetics
Published in Farmaco (Società chimica italiana : 1989) (01-11-2000)“…A new series of 1,2,4-oxadizoles 6a– g have been synthesised in good yields using the peptide synthesis strategy. The prepared compounds were tested for…”
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Synthesis, Characterization and in vitro, in vivo and in silico Anti-Inflammatory Studies of the Novel Hybrid Based on Ibuprofen and 3-Hydroxy-Copalic Acid Isolated from Copaiba Oil (Copaifera multijuga)
Published in Journal of the Brazilian Chemical Society (01-07-2020)“…A novel anti-inflammatory hybrid 3-ibuprofenyl-copalic acid (3-IbuCA) was synthesized from 3-hydroxy-copalic acid isolated from Amazonian copaiba oil…”
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Vasoactive Thiomethyl-Pyrimidines: Promising Drug Candidates with Vascular Activity
Published in Journal of the Brazilian Chemical Society (01-07-2017)“…Pyrimidines and their derivatives are present in various biologically active molecules. Most of the synthetic methods employed to achieve the pyrimidinone ring…”
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Increased respiratory rhythm and O2 and CO2 chemosensitivity in juvenile rats submitted to perinatal protein undernutrition
Published in The FASEB journal (01-04-2013)“…Abstract only We evaluated the effects of perinatal protein undernutrition on the respiratory pattern and responses to hypercapnia and hypoxia. Pregnant Wistar…”
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Schinus terebinthifolius administration prevented behavioral and biochemical alterations in a rotenone model of Parkinson's disease
Published in Revista brasileira de farmacognosia (01-03-2016)“…Parkinson's disease is a neurodegenerative disorder characterized by motor impairment, cognitive decline and psychiatric symptoms. Schinus terebinthifolius…”
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Synthesis of 1,2,3-Triazole Derivatives and em>in Vitro /em> Antifungal Evaluation on em>Candida /em> Strains
Published in Molecules (Basel, Switzerland) (01-05-2012)“…1,2,3-Triazoles have been extensively studied as compounds possessing important biological activities. In this work, we describe the synthesis of ten…”
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Evaluation of antihyperglycaemic activity of Calotropis procera leaves extract on streptozotocin-induced diabetes in Wistar rats
Published in Revista brasileira de farmacognosia (01-11-2013)“…Calotropis procera (Aiton) W. T. Aiton, Apocynaceae, popularly known as “algodão-de-seda”, is a wild African bush, rich in bioactive substances that determine…”
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