Search Results - "Wancewicz, Edward V."

Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis by Kordasiewicz, Holly B., Stanek, Lisa M., Wancewicz, Edward V., Mazur, Curt, McAlonis, Melissa M., Pytel, Kimberly A., Artates, Jonathan W., Weiss, Andreas, Cheng, Seng H., Shihabuddin, Lamya S., Hung, Gene, Bennett, C. Frank, Cleveland, Don W.

“…The primary cause of Huntington's disease (HD) is expression of huntingtin with a polyglutamine expansion. Despite an absence of consensus on the mechanism(s)…”
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A modular analysis of microglia gene expression, insights into the aged phenotype by Cho, Christine E, Damle, Sagar S, Wancewicz, Edward V, Mukhopadhyay, Swagatam, Hart, Christopher E, Mazur, Curt, Swayze, Eric E, Kamme, Fredrik

“…Microglia are multifunctional cells that are key players in brain development and homeostasis. Recent years have seen tremendous growth in our understanding of…”
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Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals by Swayze, Eric E, Siwkowski, Andrew M, Wancewicz, Edward V, Migawa, Michael T, Wyrzykiewicz, Tadeusz K, Hung, Gene, Monia, Brett P, Bennett, and C. Frank

“…A series of antisense oligonucleotides (ASOs) containing either 2'-O-methoxyethylribose (MOE) or locked nucleic acid (LNA) modifications were designed to…”
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Comparing In Vitro and In Vivo Activity of 2′-O-[2-(Methylamino)-2-oxoethyl]- and 2′-O-Methoxyethyl-Modified Antisense Oligonucleotides by Prakash, Thazha P, Kawasaki, Andrew M, Wancewicz, Edward V, Shen, Lijiang, Monia, Brett P, Ross, Bruce S, Bhat, Balkrishen, Manoharan, Muthiah

“…A number of 2′-O-modified antisense oligonucleotides have been reported for their potential use in oligonucleotide-based therapeutics. To date, most of the in…”
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Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals by Seth, Punit P, Siwkowski, Andrew, Allerson, Charles R, Vasquez, Guillermo, Lee, Sam, Prakash, Thazha P, Wancewicz, Edward V, Witchell, Donna, Swayze, Eric E

“…The potency of second generation antisense oligonucleotides (ASOs) in animals was increased 3- to 5 -fold (ED50 ≈ 2−5 mg/kg) without producing hepatotoxicity,…”
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Disruption of WT1 gene expression and exon 5 splicing following cytotoxic drug treatment: Antisense down-regulation of exon 5 alters target gene expression and inhibits cell survival by Renshaw, Jane, Orr, Rosanne M, Walton, Michael I, Te Poele, Robert, Williams, Richard D, Wancewicz, Edward V, Monia, Brett P, Workman, Paul, Pritchard-Jones, Kathryn

“…Deregulated expression of the Wilms' tumor gene ( WT1 ) has been implicated in the maintenance of a malignant phenotype in leukemias and a wide range of solid…”
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Co-Administration of an Excipient Oligonucleotide Helps Delineate Pathways of Productive and Nonproductive Uptake of Phosphorothioate Antisense Oligonucleotides in the Liver by Donner, Aaron J, Wancewicz, Edward V, Murray, Heather M, Greenlee, Sarah, Post, Noah, Bell, Melanie, Lima, Walt F, Swayze, Eric E, Seth, Punit P

“…Phosphorothioate (PS) modified antisense oligonucleotides (ASOs) have progressed rapidly in the clinic for treating a variety of disease indications. We…”
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Peptide Nucleic Acids Conjugated to Short Basic Peptides Show Improved Pharmacokinetics and Antisense Activity in Adipose Tissue by Wancewicz, Edward V, Maier, Martin A, Siwkowski, Andrew M, Albertshofer, Klaus, Winger, Theodore M, Berdeja, Andres, Gaus, Hans, Vickers, Timothy A, Bennett, C. Frank, Monia, Brett P, Griffey, Richard H, Nulf, Christopher J, Hu, Jiaxin, Corey, David R, Swayze, Eric E, Kinberger, Garth A

“…A peptide nucleic acid (PNA) targeting a splice junction of the murine PTEN primary transcript was covalently conjugated to various basic peptides. When…”
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Inhibition of hepatic endothelial E-selectin expression by C-raf antisense oligonucleotides blocks colorectal carcinoma liver metastasis by KHATIB, Abdel-Majid, FALLAVOLLITA, Lucia, WANCEWICZ, Edward V, MONIA, Brett P, BRODT, Pnina

“…Cytokine-dependent induction of E-selectin expression is mediated through cooperative signaling involving the Ras/Raf/mitogen-activated protein kinase pathway…”
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Oncogenic Homeodomain Transcription Factor E2A-Pbx1 Activates a Novel WNT Gene in Pre-B Acute Lymphoblastoid Leukemia by McWhirter, J R, Neuteboom, S T, Wancewicz, E V, Monia, B P, Downing, J R, Murre, C

“…A large fraction of pediatric pre-B acute lymphoblastoid leukemias (ALL) consistently contain a t(1;19) chromosomal translocation. The t(1;19) translocation…”
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Identification and functional validation of PNAs that inhibit murine CD40 expression by redirection of splicing by Siwkowski, Andrew M., Malik, Leila, Esau, Christine C., Maier, Martin A., Wancewicz, Edward V., Albertshofer, Klaus, Monia, Brett P., Bennett, C. Frank, Eldrup, Anne B.

“…Cognate recognition between the CD40 receptor and its ligand, CD154, is thought to play a central role in the initiation and propagation of immune responses…”
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Structure−Activity Relationship Study on a Simple Cationic Peptide Motif for Cellular Delivery of Antisense Peptide Nucleic Acid by Albertshofer, Klaus, Siwkowski, Andrew M, Wancewicz, Edward V, Esau, Christine C, Watanabe, Tanya, Nishihara, Kenji C, Kinberger, Garth A, Malik, Leila, Eldrup, Anne B, Manoharan, Muthiah, Geary, Richard S, Monia, Brett P, Swayze, Eric E, Griffey, Richard H, Bennett, C. Frank, Maier, Martin A

“…Improving cellular uptake and biodistribution remains one of the major obstacles for a successful and broad application of peptide nucleic acids (PNAs) as…”
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Evaluation of Basic Amphipathic Peptides for Cellular Delivery of Antisense Peptide Nucleic Acids by Maier, Martin A., Esau, Christine C., Siwkowski, Andrew M., Wancewicz, Edward V., Albertshofer, Klaus, Kinberger, Garth A., Kadaba, Neena S., Watanabe, Tanya, Manoharan, Muthiah, Bennett, C. Frank, Griffey, Richard H., Swayze, Eric E.

“…Cellular permeation peptides have been used successfully for the delivery of a variety of cargoes across cellular membranes, including large hydrophilic…”
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Inhibition of telomerase by 2'-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution and time inside cells by Elayadi, A N, Demieville, A, Wancewicz, E V, Monia, B P, Corey, D R

“…2'-O-(2-methoxyethyl) (2'-MOE) RNA possesses favorable pharmocokinetic properties that make it a promising option for the design of oligonucleotide drugs…”
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Protein kinase C inhibitors block the enhanced expression of intercellular adhesion molecule-1 on endothelial cells activated by interleukin-1, lipopolysaccharide and tumor necrosis factor by Lane, T A, Lamkin, G E, Wancewicz, E V

“…Interleukin 1 (IL-1), bacterial lipopolysaccharide (LPS) and tumor necrosis factor (TNF alpha) enhance the adherence properties of endothelial cells (EC) for…”
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Telomerase reverse transcriptase (hTERT) mRNA and telomerase RNA (hTR) as targets for downregulation of telomerase activity by Natarajan, Shobhana, Chen, Zhi, Wancewicz, Edward V, Monia, Brett P, Corey, David R

“…Telomerase is expressed in cancer cells but not in most normal cells, leading to the hypothesis that telomerase inhibitors may be a powerful approach to cancer…”
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Reduction of Sodium Dependent Glucose Transporter SGLT2 Expression with an Antisense Oligonucleotide (ASO) Optimized To Target the Kidney Results in Significant Glucose Lowering Effects in Diabetic Mice by Watts, Lynnetta M, Leedom, Thomas A, Wancewicz, Edward V, Siwkowski, Andrew M

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Evaluation of C-5 propynyl pyrimidine-containing oligonucleotides in vitro and in vivo by Shen, Lijiang, Siwkowski, Andrew, Wancewicz, Edward V, Lesnik, Elena, Butler, Madeline, Witchell, Donna, Vasquez, Guillermo, Ross, Bruce, Acevedo, Oscar, Inamati, Gopal, Sasmor, Henri, Manoharan, Muthiah, Monia, Brett P

“…Inclusion of C-5 propynyl pyrimidines in phosphorothioate antisense oligonucleotides (ASOs) has been shown to significantly increase their potency for…”
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Intravitreous anti-raf-1 kinase antisense oligonucleotide as an angioinhibitory agent in porcine preretinal neovascularization by Danis, Ronald P., Criswell, Mark H., Orge, Faruk, Wancewicz, Edward V., Stecker, Kim, Henry, Scott P., Monia, Brett P.

“…Purpose. To test the efficacy of a synthetic antisense oligonucleotide inhibitor of an intracellular signal transduction protein, C-raf-1 kinase, as an…”
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Inhibition of C-raf expression by antisense oligonucleotides extends heart allograft survival in rats by STEPKOWSKI, S. M, XEIMEI QU, WANG, M.-E, LING TIAN, WENHAO CHEN, WANCEWICZ, E. V, JOHNSTON, J. F, BENNETT, C. F, MONIA, B. P

“…C-raf is a well-characterized serine/ threonine (Ser/Thr) protein kinase that is involved in the transduction of multiple signals of T cells. We demonstrate…”
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