Seropositivity of Dengue Antibodies during Pregnancy

Purpose. Malaysia a dengue endemic country with dengue infections in pregnancy on the rise. The present study was aimed at determining dengue seroprevalence (IgG or IgM) during pregnancy and its neonatal transmission in dengue seropositive women. Methods. Maternal with paired cord blood samples were...

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Bibliographic Details
Published in:	TheScientificWorld Vol. 2014; no. 2014; pp. 1 - 4
Main Authors:	Salleh, Sharifah Azura, Muhammad Yassin, Muhammad Abdul Jamil, Jamal, Rahman, Neoh, Hui-Min, Mohamed Ismail, Nor Azlin, Wan Abd Rahim, Wan Elly Rushima
Format:	Journal Article
Language:	English
Published:	Cairo, Egypt Hindawi Publishing Corporation 2014 John Wiley & Sons, Inc Hindawi Limited
Subjects:	Adult Antibodies Antibodies, Viral - blood Antibodies, Viral - immunology Asymptomatic Dengue Dengue - blood Dengue - immunology Dengue fever Dengue Virus - immunology Dengue Virus - isolation & purification Dengue Virus - pathogenicity Dengue viruses Disease transmission Enzyme-Linked Immunosorbent Assay Enzymes Female Gestational age Health aspects Host-virus relationships Humans Identification and classification Immunoglobulin G - blood Immunoglobulin G - immunology Infant, Newborn Infections Malaysia Minority & ethnic groups Neonates Patients Physiological aspects Pregnancy Pregnant women Seroepidemiologic Studies Serology Vector-borne diseases Viral antibodies Womens health Malaysia Kuala Lumpur Malaysia Thailand ISEW, Malaysia
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Summary:	Purpose. Malaysia a dengue endemic country with dengue infections in pregnancy on the rise. The present study was aimed at determining dengue seroprevalence (IgG or IgM) during pregnancy and its neonatal transmission in dengue seropositive women. Methods. Maternal with paired cord blood samples were tested for dengue antibodies (IgG and IgM) using an enzyme-linked immunosorbent assay (ELISA). Maternal age, parity, occupation, ethnic group, and gestational age were recorded. Data on neonatal Apgar score and admissions to the Neonatal Intensive Care Unit (NICU) were analyzed. Results. Out of 358 women recruited, about 128 (35.8%) patients were seropositive. Twelve patients (3.4%) had recent infections (IgM positive) and another 116 women (32.4%) were with past infections (IgG positive). All babies born to seropositive mothers had positive IgG paired cord blood; however, no IgM seropositivity was observed. All neonates had good Apgar scores and did not require NICU admission. Conclusion. In this study, 35.8% pregnant women were found to be dengue seropositive. However, transplacental transfer of IgG antibodies had no detrimental effect on the neonatal outcomes.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Academic Editor: Abdul Waheed
ISSN:	2356-6140 1537-744X 1537-744X
DOI:	10.1155/2014/436975