Search Results - "Wan, Yonghong"

Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T-cell memory development by Zhang, Huafeng, Tang, Ke, Ma, Jingwei, Zhou, Li, Liu, Jincheng, Zeng, Liping, Zhu, Liyan, Xu, Pingwei, Chen, Jie, Wei, Keke, Liang, Xiaoyu, Lv, Jiadi, Xie, Jing, Liu, Yuying, Wan, Yonghong, Huang, Bo

“…Glycogen has long been considered to have a function in energy metabolism. However, our recent study indicated that glycogen metabolism, directed by cytosolic…”
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Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2 by Afkhami, Sam, D’Agostino, Michael R., Zhang, Ali, Stacey, Hannah D., Marzok, Art, Kang, Alisha, Singh, Ramandeep, Bavananthasivam, Jegarubee, Ye, Gluke, Luo, Xiangqian, Wang, Fuan, Ang, Jann C., Zganiacz, Anna, Sankar, Uma, Kazhdan, Natallia, Koenig, Joshua F.E., Phelps, Allyssa, Gameiro, Steven F., Tang, Shangguo, Jordana, Manel, Wan, Yonghong, Mossman, Karen L., Jeyanathan, Mangalakumari, Gillgrass, Amy, Medina, Maria Fe C., Smaill, Fiona, Lichty, Brian D., Miller, Matthew S., Xing, Zhou

“…The emerging SARS-CoV-2 variants of concern (VOCs) threaten the effectiveness of current COVID-19 vaccines administered intramuscularly and designed to only…”
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A Combination of Chemotherapy and Oncolytic Virotherapy Sensitizes Colorectal Adenocarcinoma to Immune Checkpoint Inhibitors in a cDC1-Dependent Manner by El-Sayes, Nader, Vito, Alyssa, Salem, Omar, Workenhe, Samuel Tekeste, Wan, Yonghong, Mossman, Karen

“…Immune checkpoint therapy has shown great promise in the treatment of cancers with a high mutational burden, such as mismatch repair-deficient colorectal…”
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HDACi promotes inflammatory remodeling of the tumor microenvironment to enhance epitope spreading and antitumor immunity by Nguyen, Andrew, Ho, Louisa, Hogg, Richard, Chen, Lan, Walsh, Scott R, Wan, Yonghong

“…Adoptive cell therapy (ACT) with tumor-specific memory T cells has shown increasing efficacy in regressing solid tumors. However, tumor antigen heterogeneity…”
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Human umbilical cord mesenchymal stem cell exosomes alleviate acute kidney injury by inhibiting pyroptosis in rats and NRK-52E cells by Wan, Yonghong, Yu, Yihang, Yu, Chengjun, Luo, Jin, Wen, Sheng, Shen, Lianju, Wei, Guanghui, Hua, Yi

“…Human umbilical cord mesenchymal stem cells (hucMSCs) have been shown to improve kidney injury. Exosomes have been indicated to be important mediators of renal…”
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Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation by Kim, Janice J, Bridle, Byram W, Ghia, Jean-Eric, Wang, Huaqing, Syed, Shahzad N, Manocha, Marcus M, Rengasamy, Palanivel, Shajib, Mohammad Sharif, Wan, Yonghong, Hedlund, Peter B, Khan, Waliul I

“…Mucosal inflammation in conditions ranging from infective acute enteritis or colitis to inflammatory bowel disease is accompanied by alteration in serotonin…”
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Cell-free tumor microparticle vaccines stimulate dendritic cells via cGAS/STING signaling by Zhang, Huafeng, Tang, Ke, Zhang, Yi, Ma, Ruihua, Ma, Jingwei, Li, Yong, Luo, Shunqun, Liang, Xiaoyu, Ji, Tiantian, Gu, Zhichao, Lu, Jinzhi, He, Wei, Cao, Xuetao, Wan, Yonghong, Huang, Bo

“…Tumor antigens and innate signals are vital considerations in developing new therapeutic or prophylactic antitumor vaccines. The role or requirement of intact…”
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Potentiating Cancer Immunotherapy Using an Oncolytic Virus by Bridle, Byram W, Stephenson, Kyle B, Boudreau, Jeanette E, Koshy, Sandeep, Kazdhan, Natasha, Pullenayegum, Eleanor, Brunellière, Jérôme, Bramson, Jonathan L, Lichty, Brian D, Wan, Yonghong

“…Oncolytic viruses (OVs) are highly immunogenic and this limits their use in immune-competent hosts. Although immunosuppression may improve viral oncolysis,…”
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S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3 by Wang, Fuan, Alain, Tommy, Szretter, Kristy J, Stephenson, Kyle, Pol, Jonathan G, Atherton, Matthew J, Hoang, Huy-Dung, Fonseca, Bruno D, Zakaria, Chadi, Chen, Lan, Rangwala, Zainab, Hesch, Adam, Chan, Eva Sin Yan, Tuinman, Carly, Suthar, Mehul S, Jiang, Zhaozhao, Ashkar, Ali A, Thomas, George, Kozma, Sara C, Gale, Michael, Fitzgerald, Katherine A, Diamond, Michael S, Mossman, Karen, Sonenberg, Nahum, Wan, Yonghong, Lichty, Brian D

“…Activation of the transcription factor IRF3 is a key event in antiviral responses. Lichty and colleagues show that recruitment of the mTOR downstream effector…”
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High Physiological Concentrations of Progesterone Reverse Estradiol-Mediated Changes in Differentiation and Functions of Bone Marrow Derived Dendritic Cells by Xiu, Fangming, Anipindi, Varun C, Nguyen, Philip V, Boudreau, Jeanette, Liang, Hong, Wan, Yonghong, Snider, Denis P, Kaushic, Charu

“…Female sex steroids, estradiol (E2) and progesterone (P4), play a key role in regulating immune responses in women, including dendritic cell (DC) development,…”
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Estradiol Enhances CD4+ T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce Th17 Responses via an IL-1-Dependent Pathway by Anipindi, Varun C, Bagri, Puja, Roth, Kristy, Dizzell, Sara E, Nguyen, Philip V, Shaler, Christopher R, Chu, Derek K, Jiménez-Saiz, Rodrigo, Liang, Hong, Swift, Stephanie, Nazli, Aisha, Kafka, Jessica K, Bramson, Jonathan, Xing, Zhou, Jordana, Manel, Wan, Yonghong, Snider, Denis P, Stampfli, Martin R, Kaushic, Charu

“…Clinical and experimental studies have shown that estradiol (E2) confers protection against HIV and other sexually transmitted infections. Here, we…”
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Preclinical evaluation of a MAGE-A3 vaccination utilizing the oncolytic Maraba virus currently in first-in-human trials by Pol, Jonathan G., Acuna, Sergio A., Yadollahi, Beta, Tang, Nan, Stephenson, Kyle B., Atherton, Matthew J., Hanwell, David, El-Warrak, Alexander, Goldstein, Alyssa, Moloo, Badru, Turner, Patricia V., Lopez, Roberto, LaFrance, Sandra, Evelegh, Carole, Denisova, Galina, Parsons, Robin, Millar, Jamie, Stoll, Gautier, Martin, Chantal G., Pomoransky, Julia, Breitbach, Caroline J., Bramson, Jonathan L., Bell, John C., Wan, Yonghong, Stojdl, David F., Lichty, Brian D., McCart, J. Andrea

“…Multiple immunotherapeutics have been approved for cancer patients, however advanced solid tumors are frequently refractory to treatment. We evaluated the…”
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HDACi Delivery Reprograms Tumor-Infiltrating Myeloid Cells to Eliminate Antigen-Loss Variants by Nguyen, Andrew, Ho, Louisa, Workenhe, Samuel T., Chen, Lan, Samson, Jonathan, Walsh, Scott R., Pol, Jonathan, Bramson, Jonathan L., Wan, Yonghong

“…Immune recognition of tumor-expressed antigens by cytotoxic CD8+ T cells is the foundation of adoptive T cell therapy (ACT) and has been shown to elicit…”
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Adaptive Antiviral Immunity Is a Determinant of the Therapeutic Success of Oncolytic Virotherapy by Sobol, Paul T, Boudreau, Jeanette E, Stephenson, Kyle, Wan, Yonghong, Lichty, Brian D, Mossman, Karen L

“…Oncolytic virotherapy, the selective killing of tumor cells by oncolytic viruses (OVs), has emerged as a promising avenue of anticancer research. We have…”
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De novo necroptosis creates an inflammatory environment mediating tumor susceptibility to immune checkpoint inhibitors by Workenhe, Samuel T., Nguyen, Andrew, Bakhshinyan, David, Wei, Jiarun, Hare, David N., MacNeill, Kelly L., Wan, Yonghong, Oberst, Andrew, Bramson, Jonathan L., Nasir, Jalees A., Vito, Alyssa, El-Sayes, Nader, Singh, Sheila K., McArthur, Andrew G., Mossman, Karen L.

“…Cancer immunotherapies using monoclonal antibodies to block inhibitory checkpoints are showing durable remissions in many types of cancer patients, although…”
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Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells by Vito, Alyssa, Salem, Omar, El-Sayes, Nader, MacFawn, Ian P., Portillo, Ana L., Milne, Katy, Harrington, Danielle, Ashkar, Ali A., Wan, Yonghong, Workenhe, Samuel T., Nelson, Brad H., Bruno, Tullia C., Mossman, Karen L.

“…Triple negative breast cancer holds a dismal clinical outcome and as such, patients routinely undergo aggressive, highly toxic treatment regimens. Clinical…”
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IFNAR blockade synergizes with oncolytic VSV to prevent virus-mediated PD-L1 expression and promote antitumor T cell activity by El-Sayes, Nader, Walsh, Scott, Vito, Alyssa, Reihani, Amir, Ask, Kjetil, Wan, Yonghong, Mossman, Karen

“…Oncolytic virotherapies have shown excellent promise in a variety of cancers by promoting antitumor immunity. However, the effects of oncolytic virus-mediated…”
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Pyroptosis activates conventional type I dendritic cells to mediate the priming of highly functional anticancer T cells by Inkol, Jordon M, Westerveld, Michael J, Verburg, Shayla G, Walsh, Scott R, Morrison, Jodi, Mossman, Karen L, Worfolk, Sarah M, Kallio, Kaslyn LF, Phippen, Noah J, Burchett, Rebecca, Wan, Yonghong, Bramson, Jonathan, Workenhe, Samuel T

“…BackgroundInitiation of antitumor immunity is reliant on the stimulation of dendritic cells (DCs) to present tumor antigens to naïve T cells and generate…”
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A Transit Time-Resolved Microflow Cytometry-Based Agglutination Immunoassay for On-Site C-Reactive Protein Detection by Qu, Jianxi, Zhang, Yushan, Chenier, Mathieu, Xu, Chang-Qing, Chen, Lan, Wan, Yonghong

“…An accurate and rapid microflow cytometry-based agglutination immunoassay (MCIA) suitable for on-site antibody or antigen detection was proposed. In this…”
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IL-15 and Type I Interferon Are Required for Activation of Tumoricidal NK Cells by Virus-Infected Dendritic Cells by BOUDREAU, Jeanette E, STEPHENSON, Kyle B, FUAN WANG, ASHKAR, Ali A, MOSSMAN, Karen L, LENZ, Laurel L, ROSENTHAL, Kenneth L, BRAMSON, Jonathan L, LICHTY, Brian D, YONGHONG WAN

“…There is increasing evidence that natural killer (NK) cells play an important role in antitumor immunity following dendritic cell (DC) vaccination. Little is…”
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