Search Results - "Wan, Qianya"
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Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development
Published in Signal transduction and targeted therapy (13-07-2020)“…Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER associated stress proteins are molecular chaperones essential for cellular…”
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Mitochondrial ATP synthase as a direct molecular target of chromium(III) to ameliorate hyperglycaemia stress
Published in Nature communications (28-03-2023)“…Chromium(III) is extensively used as a supplement for muscle development and the treatment of diabetes mellitus. However, its mode of action, essentiality, and…”
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Targeting Ser78 phosphorylation of Hsp27 achieves potent antiviral effects against enterovirus A71 infection
Published in Emerging microbes & infections (01-12-2024)“…A positive-sense (+) single-stranded RNA (ssRNA) virus (e.g. enterovirus A71, EV-A71) depends on viral polypeptide translation for initiation of virus…”
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PIM1 kinase facilitates Zika virus replication by suppressing host cells’ natural immunity
Published in Signal transduction and targeted therapy (02-06-2021)Get full text
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Erp57 facilitates ZIKV-induced DNA damage via NS2B/NS3 complex formation
Published in Emerging microbes & infections (01-12-2024)“…It is believed that DNA double-strand breaks induced by Zika virus (ZIKV) infection in pregnant women is a main reason of brain damage (e.g. microcephaly,…”
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Pim1 Impacts Enterovirus A71 Replication and Represents a Potential Target in Antiviral Therapy
Published in iScience (27-09-2019)“…Enterovirus A71 (EV-A71) infection causes hand-foot-and-mouth disease (HFMD) and fatal neurological diseases, and there are no effective treatments. Host…”
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Apobec-1 complementation factor regulates cell migration and apoptosis through Dickkopf1 by acting on its 3′ untranslated region in MCF7 cells
Published in Tumor biology (01-06-2017)“…A1CF (apobec-1 complementation factor) acts as a component of the apolipoprotein-B messenger RNA editing complex. Previous researches mainly focused on its…”
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Zeb1 Is a Potential Regulator of Six2 in the Proliferation, Apoptosis and Migration of Metanephric Mesenchyme Cells
Published in International journal of molecular sciences (06-08-2016)“…Nephron progenitor cells surround around the ureteric bud tips (UB) and inductively interact with the UB to originate nephrons, the basic units of renal…”
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Six2 Is a Coordinator of LiCl-Induced Cell Proliferation and Apoptosis
Published in International journal of molecular sciences (08-09-2016)“…The metanephric mesenchyme (MM) cells are a subset of kidney progenitor cells and play an essential role in mesenchymal-epithelial transition (MET), the key…”
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Hsp27 Responds to and Facilitates Enterovirus A71 Replication by Enhancing Viral Internal Ribosome Entry Site-Mediated Translation
Published in Journal of virology (01-05-2019)“…Enterovirus 71 (EV-A71) is a human pathogen that causes hand, foot, and mouth disease (HFMD) and fatal neurological diseases, and no effective treatment is…”
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MiR-181b targets Six2 and inhibits the proliferation of metanephric mesenchymal cells in vitro
Published in Biochemical and biophysical research communications (01-11-2013)“…•We do bio-informatics websites to analysis of Six2 3′UTR.•MiR181b is a putative miRNA which can targets Six2 3′UTR.•MiR-181b binding site in the 3′UTR of Six2…”
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miR181c promotes apoptosis and suppresses proliferation of metanephric mesenchyme cells by targeting Six2 in vitro
Published in Cell biochemistry and function (01-10-2014)“…Increasingly recognized importance has been assumed for microRNA (miRNA) in the regulation of the delicate balance of gene expression. In our study, we aimed…”
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