Search Results - "Wan, Mandy"

Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex by Wan, Mandy S. M., Muhammad, Reyhan, Koliopoulos, Marios G., Roumeliotis, Theodoros I., Choudhary, Jyoti S., Alfieri, Claudio

“…Lysine acetylation in histone tails is a key post-translational modification that controls transcription activation. Histone deacetylase complexes remove…”
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Ergocalciferol Supplementation in Children with CKD Delays the Onset of Secondary Hyperparathyroidism: A Randomized Trial by Shroff, Rukshana, Wan, Mandy, Gullett, Ambrose, Ledermann, Sarah, Shute, Rachel, Knott, Craig, Wells, David, Aitkenhead, Helen, Manickavasagar, Bahee, van't Hoff, William, Rees, Lesley

“…Vitamin D deficiency is an important contributor to the development of hyperparathyroidism and is independently associated with cardiovascular and bone…”
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Amoxicillin duration and dose for community-acquired pneumonia in children: the CAP-IT factorial non-inferiority RCT by Barratt, Sam, Bielicki, Julia A, Dunn, David, Faust, Saul N, Finn, Adam, Harper, Lynda, Jackson, Pauline, Lyttle, Mark D, Powell, Colin Ve, Rogers, Louise, Roland, Damian, Stöhr, Wolfgang, Sturgeon, Kate, Vitale, Elia, Wan, Mandy, Gibb, Diana M, Sharland, Mike

“…Data are limited regarding the optimal dose and duration of amoxicillin treatment for community-acquired pneumonia in children. To determine the efficacy,…”
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Can vitamin D slow down the progression of chronic kidney disease? by Shroff, Rukshana, Wan, Mandy, Rees, Lesley

“…Pharmacological blockade of the renin–angiotensin–aldosterone system (RAAS) is the cornerstone of renoprotective therapy, and the reduction of persistent RAAS…”
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Antibiotics for lower respiratory tract infection in children presenting in primary care: ARTIC-PC RCT by Little, Paul, Francis, Nick A, Stuart, Beth, O'Reilly, Gilly, Thompson, Natalie, Becque, Taeko, Hay, Alastair D, Wang, Kay, Sharland, Michael, Harnden, Anthony, Yao, Guiqing, Raftery, James, Zhu, Shihua, Little, Joseph, Hookham, Charlotte, Rowley, Kate, Euden, Joanne, Harman, Kim, Coenen, Samuel, Read, Robert C, Woods, Catherine, Butler, Christopher C, Faust, Saul N, Leydon, Geraldine, Wan, Mandy, Hood, Kerenza, Whitehurst, Jane, Richards-Hall, Samantha, Smith, Peter, Thomas, Michael, Moore, Michael, Verheij, Theo

“…Antimicrobial resistance is a global health threat. Antibiotics are commonly prescribed for children with uncomplicated lower respiratory tract infections, but…”
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Renal association commentary on the KDIGO (2017) clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of CKD-MBD by Burton, James O, Goldsmith, David J, Ruddock, Nicki, Shroff, Rukshana, Wan, Mandy

“…This report comments on the relevance and utility of the recently published (2017) KDIGO Clinical Practice Guideline Update for the diagnosis, evaluation,…”
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Multi-centre, randomised, open-label, blinded endpoint assessed, trial of corticosteroids plus intravenous immunoglobulin (IVIG) and aspirin, versus IVIG and aspirin for prevention of coronary artery aneurysms (CAA) in Kawasaki disease (KD): the KD CAA prevention (KD-CAAP) trial protocol by Eleftheriou, Despina, Moraes, Yolanda Collaco, Purvis, Cara, Pursell, Molly, Morillas, Marta Merida, Kahn, Robin, Mossberg, Maria, Kucera, Filip, Tulloh, Robert, Standing, Joseph F, Swallow, Veronica, McCormack, Rachael, Herberg, Jethro, Levin, Michael, Wan, Mandy, Klein, Nigel, Connon, Roisin, Walker, Ann Sarah, Brogan, Paul

“…Kawasaki disease (KD) is an acute self-limiting inflammatory vasculitis affecting predominantly medium-sized arteries, particularly the coronary arteries. A…”
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Intravenous immunoglobulin treatment in childhood encephalitis (IgNiTE): a randomised controlled trial by Hill, Matilda, Iro, Mildred, Sadarangani, Manish, Absoud, Michael, Cantrell, Liberty, Chong, Kling, Clark, Christopher, Easton, Ava, Gray, Victoria, Kneen, Rachel, Lim, Ming, Liu, Xinxue, Pike, Michael, Solomon, Tom, Vincent, Angela, Willis, Louise, Yu, Ly-Mee, Pollard, Andrew J, Pollard, Andrew J, Lim, Ming, Solomon, Tom, Kneen, Rachel, Absoud, Michael, Pike, Mike, Sadarangani, Manish, Chong, Kling, Clark, Chris A., Gray, Victoria, Iro, Mildred, Willis, Louise, Kerr, David, Bradshaw, Sophie, Milca, Svetlana, Kerridge, Simon, Plested, Emma, Mujadidi, Yama, Herwitker, Shakeel, Wan, Mandy, Cameron, Claire, Warris, Adilia, Martinon-Torres, Federico, Bale, Mike, Bale, Sonia, Percival, Alan, Easton, Ava, Warlow, Charles, Haviland, Jo, Pace, David, Nadel, Simon, Yu, Ly-Mee, Voysey, Meryn, Liu, Xinxue, Cantrell, Liberty, Bibi, Sagida, Beveridge, Amy, Thompson, Amber, O’Connor, Daniel, Irani, Sarosh, Waters, Patrick, Burke, Lauren, Alley, Parvinder, Bhate, Sanjay, Heath, Paul, Riddell, Anna, Desurkar, Archana, Stephen, Elma, Welch, Steve, McMaster, Paddy, Jollands, Alice, Shetty, Jay, Vijayakumar, Kayal, Mewasingh, Leena, Whitehouse, William, Mehta, Vishal, Alexander, John, Livingston, John, Goede, Christian de, Smith, Dominic, Collinson, Andrew

“…ObjectiveTo investigate whether intravenous immunoglobulin (IVIG) improves neurological outcomes in children with encephalitis when administered early in the…”
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Oral liquid medicines for children: the issues of choice by Wan, Mandy, Wignell, Andrew, Tomlin, Stephen

“…[...]having more than one concentration of the same drug in liquid form allows us to further tailor the volume to be administered. In two cases, a product of a…”
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P23 Off-label use of interleukin-6 inhibitors in paediatrics: a systematic review by Badshah, Hafsah, Wan, Mandy, Rashed, Asia N

“…AimElevated Interleukin-6 (IL-6) is associated with the pathogenesis of various chronic inflammation and autoimmune conditions.1 Currently, only three IL-6…”
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Trends, geographical variation and factors associated with melatonin prescribing in general practices in England: A practice‐level analysis by Wan, Mandy, Begum, Rukeya, Rashed, Asia N.

“…An overview of melatonin prescribing trends and variation in England is described in this study. Prescription reimbursement data for melatonin in England were…”
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Hypervitaminosis D and nephrocalcinosis: too much of a good thing? by Wan, Mandy, Patel, Jignesh, Rait, Greta, Shroff, Rukshana

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Gutted: constipation in children with chronic kidney disease and on dialysis by Wan, Mandy, King, Lillian, Baugh, Natasha, Arslan, Zainab, Snauwaert, Evelien, Paglialonga, Fabio, Shroff, Rukshana

“…Functional constipation is a common problem in otherwise healthy children. Children with chronic kidney disease (CKD) and on dialysis have additional…”
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The benefits of dietary fiber: the gastrointestinal tract and beyond by Snauwaert, Evelien, Paglialonga, Fabio, Vande Walle, Johan, Wan, Mandy, Desloovere, An, Polderman, Nonnie, Renken-Terhaerdt, José, Shaw, Vanessa, Shroff, Rukshana

“…Dietary fiber is considered an essential constituent of a healthy child’s diet. Diets of healthy children with adequate dietary fiber intake are characterized…”
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Pharmacy and formulation support for paediatric clinical trials in England by Wan, Mandy, Al Hashimi, Ali, Batchelor, Hannah

“…[Display omitted] Availability and sourcing of investigational drugs for paediatric clinical trials is known to be a challenge for investigator-led clinical…”
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P13 Vitamin D preparations: what’s in the bottle? by Wan, Mandy, Patel, Anish, Patel, Jignesh, Rait, Greta, Jones, Stuart, Shroff, Rukshana

“…AimThe UK incidence of vitamin D prescribing in children has increased by 26-fold in recent years.1 Public Health England recommends that children over 1 year…”
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Pharmacy and formulation support for paediatric clinical trials in England by Wan, Mandy, Hashimi, Ali Al, Batchelor, Hannah

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SP3 An exploratory study to characterise dosing instructions on dispensed paediatric medicines labels by Latheef, Faiza, Rashed, Asia, Wignell, Andrew, Tomlin, Stephen, Wan, Mandy

“…AimThe dispensing label is the primary means by which healthcare professionals communicate dosing instructions on how and when to administer a medicine to…”
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Fibroblast growth factor 23 and soluble klotho in children with chronic kidney disease by Wan, Mandy, Smith, Colette, Shah, Vanita, Gullet, Ambrose, Wells, David, Rees, Lesley, Shroff, Rukshana

“…Fibroblast growth factor 23 (FGF23), a bone-derived phosphaturic hormone, is elevated in chronic kidney disease (CKD). There are scarce data on the levels of…”
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Effect of Amoxicillin Dose and Treatment Duration on the Need for Antibiotic Re-treatment in Children With Community-Acquired Pneumonia: The CAP-IT Randomized Clinical Trial by Bielicki, Julia A, Stöhr, Wolfgang, Barratt, Sam, Dunn, David, Naufal, Nishdha, Roland, Damian, Sturgeon, Kate, Finn, Adam, Rodriguez-Ruiz, Juan Pablo, Malhotra-Kumar, Surbhi, Powell, Colin, Faust, Saul N, Alcock, Anastasia E, Hall, Dani, Robinson, Gisela, Hawcutt, Daniel B, Lyttle, Mark D, Gibb, Diana M, Sharland, Mike

“…IMPORTANCE: The optimal dose and duration of oral amoxicillin for children with community-acquired pneumonia (CAP) are unclear. OBJECTIVE: To determine whether…”
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