Search Results - "Wan, Lifeng"

Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers by Nishiguchi, Gisele A, Rico, Alice, Tanner, Huw, Aversa, Robert J, Taft, Benjamin R, Subramanian, Sharadha, Setti, Lina, Burger, Matthew T, Wan, Lifeng, Tamez, Victoriano, Smith, Aaron, Lou, Yan, Barsanti, Paul A, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Dix, Ina, Tellew, John E, Huang, Shenlin, Mathews Griner, Lesley A, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Ma, Sylvia, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Jansen, Johanna M, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Lees, Emma, Shao, Wenlin, Stuart, Darrin D, Dillon, Michael P, Ramurthy, Savithri

“…RAS oncogenes have been implicated in >30% of human cancers, all representing high unmet medical need. The exquisite dependency on CRAF kinase in KRAS mutant…”
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Defining stratigraphic oil and gas plays by modifying structural plays: A case study from the Xihu Sag, east China Sea Shelf Basin by Ding, Feng, Xie, Chunyu, Zhou, Xinghai, Jiang, Cen, Li, Kun, Wan, Lifeng, Zhang, Pei, Niu, Huawei

“…The study focuses on an area of relatively mature oil and gas exploration located in the western slope of the Xihu Sag, East China Sea Shelf Basin. Three…”
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A Review on Biomass Gasification: Effect of Main Parameters on Char Generation and Reaction by Zhang, Yuming, Wan, Lifeng, Guan, Juntao, Xiong, Qing’an, Zhang, Shu, Jin, Xin

“…Reactions between char and gasifying agents are usually the controlling step and of a core role for the overall biomass gasification process due to the…”
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Base-acid relay catalytic upgrading of coal pyrolysis volatiles over CaO and HZSM-5 catalysts by Yang, Hang, Zhang, Jiehan, Chen, Zhaohui, Wan, Lifeng, Li, Changming, Zhang, Xinyu, Li, Jianling, Tian, Ruoxuan, Yu, Jian, Gao, Shiqiu

“…The relay catalytic upgrading of coal pyrolysis volatiles employing different layouts of basic CaO and acidic HZSM-5 zeolite was proposed to improve the tar…”
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Preparation and humidity sensing properties of Fe-doped mesoporous silica SBA-15 by Qi, Qi, Zhang, Tong, Zheng, Xuejun, Wan, Lifeng

“…Fe-doped mesoporous silica SBA-15 has been studied as a humidity sensing material. Comparing with pure SBA-15, Fe-doped SBA-15 shows improved humidity sensing…”
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Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic by Ramurthy, Savithri, Taft, Benjamin R, Aversa, Robert J, Barsanti, Paul A, Burger, Matthew T, Lou, Yan, Nishiguchi, Gisele A, Rico, Alice, Setti, Lina, Smith, Aaron, Subramanian, Sharadha, Tamez, Victoriano, Tanner, Huw, Wan, Lifeng, Hu, Cheng, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Tellew, John E, Huang, Shenlin, Yue, Qin, Chaudhary, Apurva, Tian, Hung, Iyer, Raman, Hassan, A. Quamrul, Mathews Griner, Lesley A, La Bonte, Laura R, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Mishina, Yuji, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Sellers, William R, Lees, Emma, Shao, Wenlin, Dillon, Michael P, Stuart, Darrin D

“…Direct pharmacological inhibition of RAS has remained elusive, and efforts to target CRAF have been challenging due to the complex nature of RAF signaling,…”
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Synthesis of (+)-Madindoline A and (+)-Madindoline B by Wan, Lifeng, Tius, Marcus A

“…The allene ether version of the Nazarov cyclization was used to construct the cyclopentane dione portion of madindolines A and B. The racemic cyclopentane…”
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Abstract DDT01-04: Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitor by Stuart, Darrin D., Shao, Wenlin, Mishina, Yuji, Feng, Yun, Caponigro, Giordano, Cooke, Vesselina G., Rivera, Stacey, Shen, Fang, Korn, Joshua, Griner, Lesley A. Mathews, Nishiguchi, Giselle, Taft, Benjamin, Wan, Lifeng, Subramanian, Sharadha, Lou, Yan, Setti, Lina, Burger, Matthew, Tamez, Victor, Rico, Alice, Aversa, Robert, Tellew, John, Haling, Jacob R., Polyakov, Valery, Lambert, Amy, Zang, Richard, Abbema, Ann Van, Hekmat-Nejad, Mohamad, Amiri, Payman, Singh, Mallika, Keen, Nicholas, Dillon, Michael P., Lees, Emma, Sellers, William R., Ramurthy, Savithri

“…Abstract The mitogen-activated protein kinase (MAPK) signaling pathway is frequently activated in human cancers due to genetic alterations that can occur at…”
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Analysis of the path for life-cycle information sharing in urban rail transit project by Wan Lifeng, Yin Yilin, Hong, K E

“…This paper gives an analysis of participants' decision-making process about information-sharing in rail transit projects by mathematical model and the measures…”
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The time and space characteristics of magnetomotive force in the cascaded linear induction motor by Zhou, Dajing, Ma, Jiaqing, Zhao, Lifeng, Wan, Xiao, Zhang, Yong, Zhao, Yong

“…To choose a reasonable mode of three-phase winding for the improvement of the operating efficiency of cascaded linear induction motor, the time and space…”
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