Search Results - "Wan, Hong I."

ALX148 blocks CD47 and enhances innate and adaptive antitumor immunity with a favorable safety profile by Kauder, Steven E, Kuo, Tracy C, Harrabi, Ons, Chen, Amy, Sangalang, Emma, Doyle, Laura, Rocha, Sony S, Bollini, Sangeetha, Han, Bora, Sim, Janet, Pons, Jaume, Wan, Hong I

“…CD47 is a widely expressed cell surface protein that functions as an immune checkpoint in cancer. When expressed by tumor cells, CD47 can bind SIRPα on myeloid…”
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Targeting the myeloid checkpoint receptor SIRPα potentiates innate and adaptive immune responses to promote anti-tumor activity by Kuo, Tracy C, Chen, Amy, Harrabi, Ons, Sockolosky, Jonathan T, Zhang, Anli, Sangalang, Emma, Doyle, Laura V, Kauder, Steven E, Fontaine, Danielle, Bollini, Sangeetha, Han, Bora, Fu, Yang-Xin, Sim, Janet, Pons, Jaume, Wan, Hong I

“…Signal regulatory protein α (SIRPα) is a myeloid-lineage inhibitory receptor that restricts innate immunity through engagement of its cell surface ligand CD47…”
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Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced solid tumours (ASPEN-01): a first-in-human, open-label, multicentre, phase 1 dose-escalation and dose-expansion study by Lakhani, Nehal J, Chow, Laura Q M, Gainor, Justin F, LoRusso, Patricia, Lee, Keun-Wook, Chung, Hyun Cheol, Lee, Jeeyun, Bang, Yung-Jue, Hodi, Frank Stephen, Kim, Won Seog, Santana-Davila, Rafael, Fanning, Philip, Squifflet, Pierre, Jin, Feng, Kuo, Tracy C, Wan, Hong I, Pons, Jaume, Randolph, Sophia S, Messersmith, Wells A

“…Both innate and adaptive immune responses are important components of anticancer immunity. The CD47–SIRPα interaction could represent an important pathway used…”
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Assessing and mitigating the interference of ALX148, a novel CD47 blocking agent, in pretransfusion compatibility testing by Kim, Tae Yeul, Yoon, Mi Sook, Hustinx, Hein, Sim, Janet, Wan, Hong I., Kim, Hyungsuk

“…Background ALX148, a novel CD47 blocking agent, is in clinical development for the treatment of advanced solid tumors and lymphoma. Because CD47 is highly…”
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The Transmembrane Tyrosine Phosphatase DLAR Controls Motor Axon Guidance in Drosophila by Krueger, Neil X, Van Vactor, David, Wan, Hong I, Gelbart, William M, Goodman, Corey S, Saito, Haruo

“…DLAR is a receptor-like, transmembrane protein-tyrosine phosphatase in Drosophila that is expressed almost exclusively by developing neurons. Analysis of Dlar…”
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Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease by Martone, Robert L, Zhou, Hua, Atchison, Kevin, Comery, Thomas, Xu, Jane Z, Huang, Xinyi, Gong, Xioahai, Jin, Mei, Kreft, Anthony, Harrison, Boyd, Mayer, Scott C, Aschmies, Suzan, Gonzales, Cathleen, Zaleska, Margaret M, Riddell, David R, Wagner, Erik, Lu, Peimin, Sun, Shaiu-Ching, Sonnenberg-Reines, June, Oganesian, Aram, Adkins, Karissa, Leach, Michael W, Clarke, David W, Huryn, Donna, Abou-Gharbia, Magid, Magolda, Ronald, Bard, Jonathan, Frick, Glen, Raje, Sangeeta, Forlow, S Bradley, Balliet, Carrie, Burczynski, Michael E, Reinhart, Peter H, Wan, Hong I, Pangalos, Menelas N, Jacobsen, J Steven

“…The presenilin containing gamma-secretase complex is responsible for the regulated intramembraneous proteolysis of the amyloid precursor protein (APP), the…”
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1121 TAC-003, a TLR9 agonist antibody conjugate for targeted immunotherapy of Nectin-4 expressing tumors by Chen, Amy, Li, Min, Sangalang, Emma RB, Fontaine, Danielle, Chou, Tiffany, An, Mingrui, Bonacorsi, Maja, Han, Bora, Wan, Hong I, Costa, Maria Jose, Strop, Pavel

“…BackgroundActivation of Toll-Like Receptor 9 (TLR9) by unmethylated CpG oligodeoxynucleotides (CpG ODNs) promotes innate and adaptive immune responses. Tumor…”
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Functional imaging of emotional memory in bipolar disorder and schizophrenia by Whalley, Heather C, McKirdy, James, Romaniuk, Liana, Sussmann, Jessika, Johnstone, Eve C, Wan, Hong I, McIntosh, Andrew M, Lawrie, Stephen M, Hall, Jeremy

“…Objectives:  Although in current diagnostic criteria there exists a distinction between bipolar disorder and schizophrenia, many patients manifest features of…”
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Medial temporal lobe function during emotional memory in early Alzheimer's disease, mild cognitive impairment and healthy ageing: an fMRI study by Parra, Mario A, Pattan, Vivek, Wong, Dichelle, Beaglehole, Anna, Lonie, Jane, Wan, Hong I, Honey, Garry, Hall, Jeremy, Whalley, Heather C, Lawrie, Stephen M

“…Relative to intentional memory encoding, which quickly declines in Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD), incidental memory for…”
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Highwire Regulates Synaptic Growth in Drosophila by Wan, Hong I., DiAntonio, Aaron, Fetter, Richard D., Bergstrom, Kendra, Strauss, Roland, Goodman, Corey S.

“…The formation, stabilization, and growth of synaptic connections are dynamic and highly regulated processes. The glutamatergic neuromuscular junction (NMJ) in…”
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The characteristics of physical activity and gait in patients receiving radiotherapy in cancer induced bone pain by Sande, Tonje A, Scott, Angela C, Laird, Barry J.A, Wan, Hong I, Fleetwood-Walker, Susan M, Kaasa, Stein, Klepstad, Pål, Mitchell, Rory, Murray, Gordon D, Colvin, Lesley A, Fallon, Marie T

“…Abstract Background and purpose An objective measure of pain relief may add important information to patients’ self assessment, particularly after a treatment…”
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Plasma biomarkers associated with the apolipoprotein E genotype and Alzheimer disease by Soares, Holly D, Potter, William Z, Pickering, Eve, Kuhn, Max, Immermann, Frederick W, Shera, David M, Ferm, Mats, Dean, Robert A, Simon, Adam J, Swenson, Frank, Siuciak, Judith A, Kaplow, June, Thambisetty, Madhav, Zagouras, Panayiotis, Koroshetz, Walter J, Wan, Hong I, Trojanowski, John Q, Shaw, Leslie M

“…A blood-based test that could be used as a screen for Alzheimer disease (AD) may enable early intervention and better access to treatment. To apply a multiplex…”
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Use of cerebrospinal fluid biomarkers in clinical trials for schizophrenia and depression by Wan, Hong I, Soares, Holly, Waring, Jeffrey F

“…The pharmaceutical industry is increasingly using biomarkers in clinical trials in order to determine if new drug candidates are displaying the expected…”
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Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations by Ringman, John M, Schulman, Howard, Becker, Chris, Jones, Ted, Bai, Yuchen, Immermann, Fred, Cole, Gregory, Sokolow, Sophie, Gylys, Karen, Geschwind, Daniel H, Cummings, Jeffrey L, Wan, Hong I

“…To identify cerebrospinal fluid (CSF) protein changes in persons who will develop familial Alzheimer disease (FAD) due to PSEN1 and APP mutations, using…”
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Translational Medicine Lessons from Flurizan's Failure in Alzheimer's Disease (AD) Trial: Implication for Future Drug Discovery and Development for AD by Wan, Hong I., Jacobsen, J. Steve, Rutkowski, J. Lynn, Feuerstein, Giora Z.

“…Alzheimer's disease (AD) is a progressive and fatal brain disease. According to the Alzheimer's Association, as many as 5.2 million people in the United States…”
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Translational medicine perspective in development of disease modifying therapies for Alzheimer's disease: biomarkers to buy down the risk by Wan, Hong I., Hurko, Orest, Day, Mark, Rutkowski, J. Lynn

“…Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most common cause of age‐related dementia. Currently available pharmacologic…”
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Cognitive endpoints as disease biomarkers: optimizing the congruency of preclinical models to the clinic by Day, Mark, Balci, Fuat, Wan, Hong I, Fox, Gerard B, Rutkowski, J Lynn, Feuerstein, Giora

“…Cognition is a complex set of processes, including attention, learning and memory, that refers to the capacity to encode, consolidate, store and retrieve…”
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Podophyllotoxin acetate triggers anticancer effects against non-small cell lung cancer cells by promoting cell death via cell cycle arrest, ER stress and autophagy by CHOI, JAE YEON, HONG, WAN GI, CHO, JEONG HYUN, KIM, EUN MI, KIM, JONGDOO, JUNG, CHAN-HUN, HWANG, SANG-GU, UM, HONG-DUCK, PARK, JONG KUK

“…We previously reported that podophyllotoxin acetate (PA) radiosensitizes NCI-H460 cells. Here, we confirmed that PA treatment also induces cell death among two…”
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Abstract 1721: TAC-001, a toll-like receptor 9 (TLR9) agonist antibody conjugate targeting B cells, promotes anti-tumor immunity and favorable safety profile following systemic administration in preclinical models by Kuo, Tracy C., Harrabi, Ons, Chen, Amy, Sangalang, Emma R., Doyle, Laura, Fontaine, Danielle, Li, Min, Han, Bora, Pons, Jaume, Sim, Janet, Wan, Hong I.

“…Abstract Novel therapies capable of engaging both innate and adaptive immune responses may engender durable anti-tumor immunity. Activation of toll-like…”
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Abstract 562: Antibodies to Sirpα enhance innate and adaptive immune responses to promote anti-tumor activity by Kuo, Tracy C., Chen, Amy, Harrabi, Ons, Kauder, Steven E., Sangalang, Emma R., Doyle, Laura, Bollini, Sangeetha, Han, Bora, Sim, Janet, Pons, Jaume, Wan, Hong I.

“…Abstract Targeting the CD47-SIRPα myeloid checkpoint pathway represents a novel therapeutic approach to enhance anti-cancer immunity. CD47 is a widely…”
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