Search Results - "Wan, Andrea"

FoxO1 is crucial for sustaining cardiomyocyte metabolism and cell survival by Puthanveetil, Prasanth, Wan, Andrea, Rodrigues, Brian

“…Diabetic cardiomyopathy is a term used to describe cardiac muscle damage-induced heart failure. Multiple structural and biochemical reasons have been suggested…”
Get full text

Cardiomyocyte-endothelial cell control of lipoprotein lipase by Chiu, Amy Pei-Ling, Wan, Andrea, Rodrigues, Brian

“…In people with diabetes, inadequate pharmaceutical management predisposes the patient to heart failure, which is the leading cause of diabetes related death…”
Get full text

Infolding of covered stents used for aortic coarctation: Report of two cases by Wan, Andrea W., Lee, Kyong‐Jin, Benson, Lee N.

“…Covered stents have been used for the treatment of aortic coarctation to protect the arterial wall during dilation. Early results have shown them to be safe…”
Get full text

The Function of Heparanase in Diabetes and its Complications by Wang, Fang, PhD, Wan, Andrea, BScP, Rodrigues, Brian, PhD

“…Abstract Heparan sulfate proteoglycans are ubiquitous glycoproteins that contain several heparan sulfate polysaccharide side chains attached to a core protein…”
Get full text

Endothelial cell-cardiomyocyte crosstalk in diabetic cardiomyopathy by Wan, Andrea, Rodrigues, Brian

“…The incidence of diabetes is increasing globally, with cardiovascular disease accounting for a substantial number of diabetes-related deaths. Although…”
Get full text

Comparison of Impact of Prenatal Versus Postnatal Diagnosis of Congenitally Corrected Transposition of the Great Arteries by Wan, Andrea W., MD, Jevremovic, Alexandra, MD, Selamet Tierney, Elif Seda, MD, McCrindle, Brian W., MD, Dunn, Elizabeth, MD, Manlhiot, Cedric, BSc, Wald, Rachel M., MD, Kingdom, John P., MD, Jaeggi, Edgar T., MD, Nield, Lynne E., MD

“…Congenitally corrected transposition of the great arteries (CCTGA) in the absence of major cardiac anomalies is thought to have a good outcome, although this…”
Get full text

Neonatal Interventions for Left-Sided Obstructive Lesions by Wan, Andrea, MD, FRCPC, Benson, Lee, MD, FRCPC, FSCAI

“…Percutaneous neonatal cardiac interventions are effective in management strategies. Aortic valve dilation has become a first line therapy with excellent…”
Get full text

Complex Interventions in the Adult with Congenital Heart Disease: Percutaneous Solutions for Venous Baffles, Coronary Artery Fistulas, and Ruptured Sinus of Valsalva Aneurysms by Singh, Harsimran S, Nagy, Christian, Wan, Andrea W, Osten, Mark D, Benson, Lee N, Horlick, Eric M

“…We describe 3 distinct ACHD lesions amenable to percutaneous repair: (1) venous baffle obstruction in transposition of the great arteries, (2) coronary artery…”
Get full text

Palliative Care?! But This Child’s Not Dying: The Burgeoning Partnership Between Pediatric Cardiology and Palliative Care by Wan, Andrea, Weingarten, Kevin, Rapoport, Adam

“…The field of pediatric cardiology has witnessed major changes over the past few decades that have considerably altered patient outcomes, including decreasing…”
Get full text

Complex Interventions in the Adult with Congenital Heart Disease by Singh, Harsimran S., MD, MSc, Nagy, Christian, MD, Wan, Andrea W., MD, Osten, Mark D., MD, Benson, Lee N., MD, Horlick, Eric M., MD, CM, FRCPC

“…We describe 3 distinct ACHD lesions amenable to percutaneous repair: (1) venous baffle obstruction in transposition of the great arteries, (2) coronary artery…”
Get full text

Valproic Acid–Associated Hyperammonemia: A Systematic Review by Wong, Yiu-Ching Jennifer, Fan, Julia, Wan, Andrea, Mihic, Tamara, Gnyra, Michelle

“…Hyperammonemia is an adverse effect that poses clinical uncertainty around valproic acid (VPA) use. The prevalence of symptomatic and asymptomatic…”
Get full text

Valproic Acid-Associated Hyperammonemia: A Systematic Review-Reply to Comments by Dr Aney by Wong, Yiu-Ching Jennifer, Mihic, Tamara, Wan, Andrea, Fan, Julia, Gnyra, Michelle

Get full text

Lipoprotein lipase and angiopoietin-like 4 - Cardiomyocyte secretory proteins that regulate metabolism during diabetic heart disease by Puthanveetil, Prasanth, Wan, Andrea, Rodrigues, Brian

“…Cardiac diseases have been extensively studied following diabetes and altered metabolism has been implicated in its initiation. In this context, there is a…”
Get full text

Diabetes triggers a PARP1 mediated death pathway in the heart through participation of FoxO1 by Puthanveetil, Prasanth, Zhang, Dahai, Wang, Ying, Wang, Fang, Wan, Andrea, Abrahani, Ashraf, Rodrigues, Brian

“…Abstract Cardiomyocyte cell death is a major contributing factor for diabetic cardiomyopathy, and multiple mechanisms have been proposed for its development…”
Get full text

Loss of VEGFB and its signaling in the diabetic heart is associated with increased cell death signaling by Lal, Nathaniel, Chiu, Amy Pei-Ling, Wang, Fulong, Zhang, Dahai, Jia, Jocelyn, Wan, Andrea, Vlodavsky, Israel, Hussein, Bahira, Rodrigues, Brian

“…Vascular endothelial growth factor B (VEGFB) is highly expressed in metabolically active tissues, such as the heart and skeletal muscle, suggesting a function…”
Get more information

Human Defensin 5 Disulfide Array Mutants: Disulfide Bond Deletion Attenuates Antibacterial Activity against Staphylococcus aureus by Wanniarachchi, Yoshitha A, Kaczmarek, Piotr, Wan, Andrea, Nolan, Elizabeth M

“…Human α-defensin 5 (HD5, HD5ox to specify the oxidized and disulfide linked form) is a 32-residue cysteine-rich host-defense peptide, expressed and released by…”
Get full text

Abstract 13158: Improving Clinical Outcomes by Implementing a Multi-Disciplinary Pulmonary Vein Stenosis Team by Vanderlaan, Rachel D, Dragulescu, Andreea, Tran, Crystal, Fan, Steve, Wan, Andrea, Yoo, Shi Joon D, Seed, Mike, Grosse-Wortmann, Lars, Grasemann, Harmut, Honjo, Osami, Barron, David, Russell, Jennifer L, Caldarone, Christopher

“…IntroductionPulmonary vein stenosis (PVS) is a rare disease that is associated with high mortality. In 2015, we instituted a multidisciplinary PVS team and…”
Get full text

Cardiomyocyte VEGF Regulates Endothelial Cell GPIHBP1 to Relocate Lipoprotein Lipase to the Coronary Lumen During Diabetes Mellitus by Chiu, Amy Pei-Ling, Wan, Andrea, Lal, Nathaniel, Zhang, Dahai, Wang, Fulong, Vlodavsky, Israel, Hussein, Bahira, Rodrigues, Brian

“…OBJECTIVE—Lipoprotein lipase (LPL)–mediated triglyceride hydrolysis is the major source of fatty acid for cardiac energy. LPL, synthesized in cardiomyocytes,…”
Get full text

Dual effects of hyperglycemia on endothelial cells and cardiomyocytes to enhance coronary LPL activity by Chiu, Amy Pei-Ling, Bierende, Denise, Lal, Nathaniel, Wang, Fulong, Wan, Andrea, Vlodavsky, Israel, Hussein, Bahira, Rodrigues, Brian

“…In the diabetic heart, there is excessive dependence on fatty acid (FA) utilization to generate ATP. Lipoprotein lipase (LPL)-mediated hydrolysis of…”
Get more information

High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature by Wang, Fulong, Jia, Jocelyn, Lal, Nathaniel, Zhang, Dahai, Chiu, Amy Pei-Ling, Wan, Andrea, Vlodavsky, Israel, Hussein, Bahira, Rodrigues, Brian

“…The secretion of enzymatically active heparanase (Hep ) has been implicated as an essential metabolic adaptation in the heart following diabetes. However, the…”
Get full text