Search Results - "Waman, Yogesh"
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Design and synthesis of novel, potent and selective hypoxanthine analogs as adenosine A 1 receptor antagonists and their biological evaluation
Published in Bioorganic & medicinal chemistry (15-03-2017)“…Multipronged approach was used to synthesize a library of diverse C-8 cyclopentyl hypoxanthine analogs from a common intermediate III. Several potent and…”
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Design and synthesis of novel, potent and selective hypoxanthine analogs as adenosine A1 receptor antagonists and their biological evaluation
Published in Bioorganic & medicinal chemistry (15-03-2017)“…[Display omitted] Multipronged approach was used to synthesize a library of diverse C-8 cyclopentyl hypoxanthine analogs from a common intermediate III…”
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3
N‑Arylation of Carbamates through Photosensitized Nickel Catalysis
Published in Journal of organic chemistry (16-11-2018)“…A highly efficient method of visible light mediated Ni(II)-catalyzed photoredox N-arylation of Cbz-amines/Boc-amines with aryl electrophiles at room…”
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Asymmetric Synthesis 1‑Substituted 2,6-Diazaspiro[3.3]heptanes through Addition of 3‑Azetidinecarboxylate Anions to Davis–Ellman Imines
Published in Organic letters (17-05-2019)“…Asymmetric synthesis of 1-substituted 2,6-diazaspiro[3.3]heptane is described. This methodology affords excellent yields (up to 89%) and high diastereomeric…”
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Asymmetric Synthesis of α‑(Diarylmethyl) Alkyl Amines through Regioselective Lithiation of α‑Diarylmethanes and the Diastereoselective Addition to Ellman’s Imines
Published in Journal of organic chemistry (15-06-2018)“…A highly regio- and diastereoselective lithiation/addition of α-diarylmethanes to N-tert-butanesulfinylimines is reported. This methodology also affords the…”
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Design and synthesis of novel xanthine derivatives as potent and selective A2B adenosine receptor antagonists for the treatment of chronic inflammatory airway diseases
Published in European journal of medicinal chemistry (07-07-2017)“…Adenosine induces bronchial hyperresponsiveness and inflammation in asthmatics through activation of A2B adenosine receptor (A2BAdoR). Selective antagonists…”
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Modifications of flexible nonyl chain and nucleobase head group of (+)-erythro-9-(2′s-hydroxy-3′s-nonyl)adenine [(+)-EHNA] as adenosine deaminase inhibitors
Published in Bioorganic & medicinal chemistry (15-10-2017)“…[Display omitted] A series of terminal nonyl chain and nucleobase modified analogues of (+)-EHNA (III) were synthesized and evaluated for their ability to…”
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Design and synthesis of novel xanthine derivatives as potent and selective A 2B adenosine receptor antagonists for the treatment of chronic inflammatory airway diseases
Published in European journal of medicinal chemistry (07-07-2017)“…Adenosine induces bronchial hyperresponsiveness and inflammation in asthmatics through activation of A adenosine receptor (A AdoR). Selective antagonists have…”
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Discovery of novel and potent heterocyclic carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors
Published in Bioorganic & medicinal chemistry letters (15-04-2012)“…A series of novel heterocyclic carboxylic acid based protein tyrosine phosphatase 1B (PTP1B) inhibitors with hydrophobic tail are described. Structure–activity…”
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A2B adenosine receptor antagonists: Design, synthesis and biological evaluation of novel xanthine derivatives
Published in European journal of medicinal chemistry (15-02-2017)“…A2BAdoR is a low affinity adenosine receptor that functions by Gs mediated elevation of cAMP and subsequent downstream signaling. The receptor has been…”
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A 2B adenosine receptor antagonists: Design, synthesis and biological evaluation of novel xanthine derivatives
Published in European journal of medicinal chemistry (15-02-2017)“…A doR is a low affinity adenosine receptor that functions by Gs mediated elevation of cAMP and subsequent downstream signaling. The receptor has been…”
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