Search Results - "Walus, Lee R."

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  1. 1

    Blood-Brain Barrier Penetration and in Vivo Activity of an NGF Conjugate by Friden, Phillip M., Walus, Lee R., Watson, Patricia, Doctrow, Susan R., Kozarich, John W., Bäckman, Cristina, Bergman, Hanna, Hoffer, Barry, Bloom, Floyd, Granholm, Ann-Charlotte

    “…Nerve growth factor (NGF) is essential for the survival of both peripheral ganglion cells and central cholinergic neurons of the basal forebrain. The…”
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    Journal Article
  2. 2

    Synthesis, in vitro kinetics and in vivo studies on protein conjugates of AZT: Evaluation as a transport system to increase brain delivery by Tadayoni, B. Mitra, Friden, Phillip M, Walus, Lee R, Musso, Gary F

    Published in Bioconjugate chemistry (01-03-1993)
    “…Our method to increase the delivery of polar drugs to the central nervous system is via drug-protein conjugates with proteins that interact with and cross…”
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  3. 3

    Anti-Transferrin Receptor Antibody and Antibody-Drug Conjugates Cross the Blood-Brain Barrier by Friden, Phillip M., Walus, Lee R., Musso, Gary F., Taylor, Marjorie A., Malfroy, Bernard, Starzyk, Ruth M.

    “…Delivery of nonlipophilic drugs to the brain is hindered by the tightly apposed capillary endothelial cells that make up the blood-brain barrier. We have…”
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    Enhanced uptake of rsCD4 across the rodent and primate blood-brain barrier after conjugation to anti-transferrin receptor antibodies by Walus, L R, Pardridge, W M, Starzyk, R M, Friden, P M

    “…The delivery to the brain of nonlipophilic therapeutic compounds, especially proteins, is severely hindered by the presence of the blood-brain barrier, which…”
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  6. 6

    Characterization, receptor mapping and blood-brain barrier transcytosis of antibodies to the human transferrin receptor by Friden, P M, Olson, T S, Obar, R, Walus, L R, Putney, S D

    “…Monoclonal antibodies to the human transferrin receptor were screened for binding to capillary vessels in human, monkey, rabbit and rat brain tissue. Two…”
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