Search Results - "Walus, Lee R."
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Blood-Brain Barrier Penetration and in Vivo Activity of an NGF Conjugate
Published in Science (American Association for the Advancement of Science) (15-01-1993)“…Nerve growth factor (NGF) is essential for the survival of both peripheral ganglion cells and central cholinergic neurons of the basal forebrain. The…”
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Synthesis, in vitro kinetics and in vivo studies on protein conjugates of AZT: Evaluation as a transport system to increase brain delivery
Published in Bioconjugate chemistry (01-03-1993)“…Our method to increase the delivery of polar drugs to the central nervous system is via drug-protein conjugates with proteins that interact with and cross…”
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Anti-Transferrin Receptor Antibody and Antibody-Drug Conjugates Cross the Blood-Brain Barrier
Published in Proceedings of the National Academy of Sciences - PNAS (01-06-1991)“…Delivery of nonlipophilic drugs to the brain is hindered by the tightly apposed capillary endothelial cells that make up the blood-brain barrier. We have…”
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Intravenous Administration of a Transferrin Receptor Antibody-Nerve Growth Factor Conjugate Prevents the Degeneration of Cholinergic Striatal Neurons in a Model of Huntington Disease
Published in Proceedings of the National Academy of Sciences - PNAS (13-09-1994)“…Intrastriatal injections of quinolinic acid induce a pattern of neuronal degeneration similar to that seen in Huntington disease. In the present study, nerve…”
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Enhanced uptake of rsCD4 across the rodent and primate blood-brain barrier after conjugation to anti-transferrin receptor antibodies
Published in The Journal of pharmacology and experimental therapeutics (01-05-1996)“…The delivery to the brain of nonlipophilic therapeutic compounds, especially proteins, is severely hindered by the presence of the blood-brain barrier, which…”
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Characterization, receptor mapping and blood-brain barrier transcytosis of antibodies to the human transferrin receptor
Published in The Journal of pharmacology and experimental therapeutics (01-09-1996)“…Monoclonal antibodies to the human transferrin receptor were screened for binding to capillary vessels in human, monkey, rabbit and rat brain tissue. Two…”
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Blood-brain barrier penetration and in vitro activity of an NGF conjugate
Published in Science (American Association for the Advancement of Science) (15-01-1993)Get full text
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