Search Results - "Walton, William G"

Plant "helper" immune receptors are Ca2+-permeable nonselective cation channels by Jacob, Pierre, Kim, Nak Hyun, Wu, Feihua, El-Kasmi, Farid, Chi, Yuan, Walton, William G, Furzer, Oliver J, Lietzan, Adam D, Sunil, Sruthi, Kempthorn, Korina, Redinbo, Matthew R, Pei, Zhen-Ming, Wan, Li, Dangl, Jeffery L

“…Plant nucleotide-binding leucine-rich repeat receptors (NLRs) regulate immunity and cell death. In Arabidopsis, a subfamily of "helper" NLRs is required by…”
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Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways by Garland, Alaina L., Walton, William G., Coakley, Raymond D., Tan, Chong D., Gilmore, Rodney C., Hobbs, Carey A., Tripathy, Ashutosh, Clunes, Lucy A., Bencharit, Sompop, Stutts, M. Jackson, Betts, Laurie, Redinbo, Matthew R., Tarran, Robert

“…The ability to maintain proper airway surface liquid (ASL) volume homeostasis is vital for mucus hydration and clearance, which are essential aspects of the…”
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Targeting the pregnane X receptor using microbial metabolite mimicry by Dvořák, Zdeněk, Kopp, Felix, Costello, Cait M, Kemp, Jazmin S, Li, Hao, Vrzalová, Aneta, Štěpánková, Martina, Bartoňková, Iveta, Jiskrová, Eva, Poulíková, Karolína, Vyhlídalová, Barbora, Nordstroem, Lars U, Karunaratne, Chamini V, Ranhotra, Harmit S, Mun, Kyu Shik, Naren, Anjaparavanda P, Murray, Iain A, Perdew, Gary H, Brtko, Julius, Toporova, Lucia, Schön, Arne, Wallace, Bret D, Walton, William G, Redinbo, Matthew R, Sun, Katherine, Beck, Amanda, Kortagere, Sandhya, Neary, Michelle C, Chandran, Aneesh, Vishveshwara, Saraswathi, Cavalluzzi, Maria M, Lentini, Giovanni, Cui, Julia Yue, Gu, Haiwei, March, John C, Chatterjee, Shirshendu, Matson, Adam, Wright, Dennis, Flannigan, Kyle L, Hirota, Simon A, Sartor, Ryan Balfour, Mani, Sridhar

“…The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing…”
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Enhanced biofilm prevention activity of a SPLUNC1-derived antimicrobial peptide against Staphylococcus aureus by Yu, Zhongjie, Deslouches, Berthony, Walton, William G, Redinbo, Matthew R, Di, Y Peter

“…SPLUNC1 is a multifunctional protein of the airway with antimicrobial properties. We previously reported that it displayed antibiofilm activities against P…”
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unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa by Marden, Jeremiah N., Diaz, Manisha R., Walton, William G., Gode, Cindy J., Betts, Laurie, Urbanowski, Mark L., Redinbo, Matthew R., Yahr, Timothy L., Wolfgang, Matthew C.

“…Members of the CsrA family of prokaryotic mRNA-binding proteins alter the translation and/or stability of transcripts needed for numerous global physiological…”
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Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor by Wu, Tongde, Huang, Julianne, Moore, Patrick J., Little, Michael S., Walton, William G., Fellner, Robert C., Alexis, Neil E., Peter Di, Y., Redinbo, Matthew R., Tilley, Stephen L., Tarran, Robert

“…Asthma is a chronic airway disease characterized by inflammation, mucus hypersecretion and abnormal airway smooth muscle (ASM) contraction. Bacterial…”
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Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception by Pellock, Samuel J, Creekmore, Benjamin C, Walton, William G, Mehta, Naimee, Biernat, Kristen A, Cesmat, Andrew P, Ariyarathna, Yamuna, Dunn, Zachary D, Li, Bo, Jin, Jian, James, Lindsey I, Redinbo, Matthew R

“…Microbial β-glucuronidases (GUSs) cause severe gut toxicities that limit the efficacy of cancer drugs and other therapeutics. Selective inhibitors of bacterial…”
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Mouse Gut Microbiome-Encoded β-Glucuronidases Identified Using Metagenome Analysis Guided by Protein Structure by Creekmore, Benjamin C, Gray, Josh H, Walton, William G, Biernat, Kristen A, Little, Michael S, Xu, Yongmei, Liu, Jian, Gharaibeh, Raad Z, Redinbo, Matthew R

“…Gut microbial β-glucuronidase (GUS) enzymes play important roles in drug efficacy and toxicity, intestinal carcinogenesis, and mammalian-microbial symbiosis…”
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Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus by Edwards, Jonathan S., Betts, Laurie, Frazier, Monica L., Pollet, Rebecca M., Kwong, Stephen M., Walton, William G., Ballentine, W. Keith, Huang, Julianne J., Habibi, Sohrab, Campo, Mark Del, Meier, Jordan L., Dervan, Peter. B., Firth, Neville, Redinbo, Matthew R.

“…Multidrug-resistant Staphylococcus aureus infections pose a significant threat to human health. Antibiotic resistance is most commonly propagated by…”
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Structural basis for the regulation of β-glucuronidase expression by human gut Enterobacteriaceae by Little, Michael S., Pellock, Samuel J., Walton, William G., Tripathy, Ashutosh, Redinbo, Matthew R.

“…The gut microbiota harbor diverse β-glucuronidase (GUS) enzymes that liberate glucuronic acid (GlcA) sugars from small-molecule conjugates and complex…”
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An Atlas of β-Glucuronidases in the Human Intestinal Microbiome by Pollet, Rebecca M., D'Agostino, Emma H., Walton, William G., Xu, Yongmei, Little, Michael S., Biernat, Kristen A., Pellock, Samuel J., Patterson, Loraine M., Creekmore, Benjamin C., Isenberg, Hanna N., Bahethi, Rohini R., Bhatt, Aadra P., Liu, Jian, Gharaibeh, Raad Z., Redinbo, Matthew R.

“…Microbiome-encoded β-glucuronidase (GUS) enzymes play important roles in human health by metabolizing drugs in the gastrointestinal (GI) tract. The numbers,…”
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SPLUNC1 is an allosteric modulator of the epithelial sodium channel by Kim, Christine Seulki, Ahmad, Saira, Wu, Tongde, Walton, William G., Redinbo, Matthew R., Tarran, Robert

“…Cystic fibrosis (CF) is a common genetic disease with significantly increased mortality. CF airways exhibit ion transport abnormalities, including…”
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Three structurally and functionally distinct β-glucuronidases from the human gut microbe Bacteroides uniformis by Pellock, Samuel J., Walton, William G., Biernat, Kristen A., Torres-Rivera, Dariana, Creekmore, Benjamin C., Xu, Yongmei, Liu, Jian, Tripathy, Ashutosh, Stewart, Lance J., Redinbo, Matthew R.

“…The glycoside hydrolases encoded by the human gut microbiome play an integral role in processing a variety of exogenous and endogenous glycoconjugates. Here we…”
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Structural Insights into Endobiotic Reactivation by Human Gut Microbiome-Encoded Sulfatases by Ervin, Samantha M, Simpson, Joshua B, Gibbs, Morgan E, Creekmore, Benjamin C, Lim, Lauren, Walton, William G, Gharaibeh, Raad Z, Redinbo, Matthew R

“…Phase II drug metabolism inactivates xenobiotics and endobiotics through the addition of either a glucuronic acid or sulfate moiety prior to excretion, often…”
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Selecting a Single Stereocenter: The Molecular Nuances That Differentiate β‑Hexuronidases in the Human Gut Microbiome by Pellock, Samuel J, Walton, William G, Redinbo, Matthew R

“…The human gut microbiome is a ripe space for the discovery of new proteins and novel functions. Many genes in the gut microbiome encode glycoside hydrolases…”
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Structure, function, and inhibition of drug reactivating human gut microbial β-glucuronidases by Biernat, Kristen A., Pellock, Samuel J., Bhatt, Aadra P., Bivins, Marissa M., Walton, William G., Tran, Bich Ngoc T., Wei, Lianjie, Snider, Michael C., Cesmat, Andrew P., Tripathy, Ashutosh, Erie, Dorothy A., Redinbo, Matthew R.

“…Bacterial β-glucuronidase (GUS) enzymes cause drug toxicity by reversing Phase II glucuronidation in the gastrointestinal tract. While many human gut microbial…”
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Discovery of CHD1 Antagonists for PTEN-Deficient Prostate Cancer by Johnson, Rebecca L., Graboski, Amanda L., Li, Fengling, Norris-Drouin, Jacqueline L., Walton, William G., Arrowsmith, Cheryl H., Redinbo, Matthew R., Frye, Stephen V., James, Lindsey I.

“…CHD1 is a chromodomain-helicase DNA-binding protein that preferentially recognizes di- and trimethylated lysine 4 on histone H3 (H3K4me2/3). Genetic studies…”
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Targeting Regorafenib-Induced Toxicity through Inhibition of Gut Microbial β‑Glucuronidases by Ervin, Samantha M, Hanley, Ronan P, Lim, Lauren, Walton, William G, Pearce, Kenneth H, Bhatt, Aadra P, James, Lindsey I, Redinbo, Matthew R

“…Regorafenib (Stivarga) is an oral small molecule kinase inhibitor used to treat metastatic colorectal cancer, hepatocellular carcinomas, and gastrointestinal…”
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Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor by Bartolini, Desirée, De Franco, Francesca, Torquato, Pierangelo, Marinelli, Rita, Cerra, Bruno, Ronchetti, Riccardo, Schon, Arne, Fallarino, Francesca, De Luca, Antonella, Bellezza, Guido, Ferri, Ivana, Sidoni, Angelo, Walton, William G, Pellock, Samuel J, Redinbo, Matthew R, Mani, Sridhar, Pellicciari, Roberto, Gioiello, Antimo, Galli, Francesco

“…Pregnane X receptor (PXR) is a master xenobiotic-sensing transcription factor and a validated target for immune and inflammatory diseases. The identification…”
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Short Palate, Lung, and Nasal Epithelial Clone 1 Has Antimicrobial and Antibiofilm Activities against the Burkholderia cepacia Complex by Ahmad, Saira, Tyrrell, Jean, Walton, William G, Tripathy, Ashutosh, Redinbo, Matthew R, Tarran, Robert

“…The opportunistic bacteria of the Burkholderia cepacia complex (Bcc) are extremely pathogenic to cystic fibrosis (CF) patients, and acquisition of Bcc bacteria…”
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