Search Results - "Walton, Paul A."

The peroxisomal import receptor PEX5 functions as a stress sensor, retaining catalase in the cytosol in times of oxidative stress by Walton, Paul A., Brees, Chantal, Lismont, Celien, Apanasets, Oksana, Fransen, Marc

“…Accumulating evidence indicates that peroxisome functioning, catalase localization, and cellular oxidative balance are intimately interconnected. Nevertheless,…”
Get full text

Progeric effects of catalase inactivation in human cells by Koepke, Jay I., Wood, Christopher S., Terlecky, Laura J., Walton, Paul A., Terlecky, Stanley R.

“…Peroxisomes generate hydrogen peroxide, a reactive oxygen species, as part of their normal metabolism. A number of pathological situations exist in which the…”
Get full text

Restoration of Peroxisomal Catalase Import in a Model of Human Cellular Aging by Koepke, Jay I, Nakrieko, Kerry-Ann, Wood, Christopher S, Boucher, Krissy K, Terlecky, Laura J, Walton, Paul A, Terlecky, Stanley R

“…Peroxisomes play an important role in human cellular metabolism by housing enzymes involved in a number of essential biochemical pathways. Many of these…”
Get full text

Peroxisome senescence in human fibroblasts by Legakis, Julie E, Koepke, Jay I, Jedeszko, Chris, Barlaskar, Ferdous, Terlecky, Laura J, Edwards, Holly J, Walton, Paul A, Terlecky, Stanley R

“…The molecular mechanisms of peroxisome biogenesis have begun to emerge; in contrast, relatively little is known about how the organelle functions as cells age…”
Get full text

Quantitative Monitoring of Subcellular Redox Dynamics in Living Mammalian Cells Using RoGFP2-Based Probes by Lismont, Celien, Walton, Paul A, Fransen, Marc

“…To gain additional insight into how specific cell organelles may participate in redox signaling, it is essential to have access to tools and methodologies that…”
Get more information

Effects of peroxisomal catalase inhibition on mitochondrial function by Walton, Paul A, Pizzitelli, Michael

“…Peroxisomes produce hydrogen peroxide as a metabolic by-product of their many oxidase enzymes, but contain catalase that breaks down hydrogen peroxide in order…”
Get full text

The Pleckstrin Homology Domain of CK2 Interacting Protein-1 Is Required for Interactions and Recruitment of Protein Kinase CK2 to the Plasma Membrane by Olsten, Mary Ellen K, Canton, David A, Zhang, Cunjie, Walton, Paul A, Litchfield, David W

“…CKIP-1 is a recently identified interaction partner of protein kinase CK2 with a number of protein-protein interaction motifs, including an N-terminal…”
Get full text

Microglial Inflammation and Cognitive Dysfunction in Comorbid Rat Models of Striatal Ischemic Stroke and Alzheimer’s Disease: Effects of Antioxidant Catalase-SKL on Behavioral and Cellular Pathology by MacKenzie, Jennifer L., Ivanova, Nadezda, Nell, Hayley J., Giordano, Courtney R., Terlecky, Stanley R., Agca, Cansu, Agca, Yuksel, Walton, Paul A., Whitehead, Shawn N., Cechetto, David F.

“…•Brain ischemia in amyloid-β25–35 injected rat increases basal forebrain microgliosis.•Increased striatal microglia inflammation in transgenic rat with…”
Get full text

Hypocatalasemic Fibroblasts Accumulate Hydrogen Peroxide and Display Age‐Associated Pathologies by Wood, Christopher S., Koepke, Jay I., Teng, Hua, Boucher, Krissy K., Katz, Sharon, Chang, Patrick, Terlecky, Laura J., Papanayotou, Irene, Walton, Paul A., Terlecky, Stanley R.

“…Human epidemiological studies point to an association of hypocatalasemia and an increased risk of age‐related disease. Unfortunately, the cellular and…”
Get full text

Peroxisomes and aging by Terlecky, Stanley R., Koepke, Jay I., Walton, Paul A.

“…Peroxisomes are indispensable for proper functioning of human cells. They efficiently compartmentalize enzymes responsible for a number of metabolic processes,…”
Get full text

Amyloid-beta neuroprotection mediated by a targeted antioxidant by Giordano, Courtney R., Terlecky, Laura J., Bollig-Fischer, Aliccia, Walton, Paul A., Terlecky, Stanley R.

“…Amyloid-beta (Aβ)-induced neurotoxicity is a major contributor to the pathologies associated with Alzheimer's disease (AD). The formation of reactive oxygen…”
Get full text

Brain Targeting and Toxicological Assessment of the Extracellular Vesicle-Packaged Antioxidant Catalase-SKL Following Intranasal Administration in Mice by Hayes, Sarah H., Liu, Qingfan, Selvakumaran, Sureka, Haney, Matthew J., Batrakova, Elena V., Allman, Brian L., Walton, Paul A., Kiser, Patti, Whitehead, Shawn N.

“…The antioxidant enzyme catalase represents an important therapeutic target due to its role in mitigating cellular reactive oxygen species that contribute to…”
Get full text

Targeted Antioxidant, Catalase–SKL, Reduces Beta‐Amyloid Toxicity in the Rat Brain by Nell, Hayley J., Au, Jennifer. L., Giordano, Courtney R., Terlecky, Stanley R., Walton, Paul A., Whitehead, Shawn N., Cechetto, David.F.

“…Accumulation of beta‐amyloid (Aβ) in the brain has been implicated as a major contributor to the cellular pathology and cognitive impairment observed in…”
Get full text

Requirement for Microtubules and Dynein Motors in the Earliest Stages of Peroxisome Biogenesis by Brocard, Cécile B., Boucher, Krissy K., Jedeszko, Christopher, Kim, Peter K., Walton, Paul A.

“…Our aim was to determine the role of microtubules in the biogenesis of peroxisomes. Fusion experiments between human PEX16‐ and PEX1‐mutant cells in the…”
Get full text

Migration of coordinated cell clusters in mesenchymal and epithelial cancer explants in vitro by FRIEDL, P, NOBLE, P. B, WALTON, P. A, LAIRD, D. W, CHAUVIN, P. J, TABAH, R. J, BLACK, M, ZÄNKER, K. S

“…The invasion and migration occurring in primary neoplastic tissue explants were studied by using a three-dimensional collagen matrix model, subsequent…”
Get full text

Protein Structure and Import Into the Peroxisomal Matrix by Brocard, Cécile B., Jedeszko, Christopher, Song, Hong Chang, Terlecky, Stanley R., Walton, Paul A.

“…Proteins destined for the peroxisomal matrix are synthesized in the cytosol, and imported post‐translationally. It has been previously demonstrated that stably…”
Get full text

Lipid-Modified, Cysteinyl-Containing Peptides of Diverse Structures Are Efficiently S-Acylated at the Plasma Membrane of Mammalian Cells by Schroeder, Hans, Leventis, Rania, Shahinian, Serge, Walton, Paul A., Silvius, John R.

“…A variety of cysteine-containing, lipid-modified peptides are found to be S-acylated by cultured mammalian cells. The acylation reaction is highly specific for…”
Get full text

Involvement of 70-kD Heat-Shock Proteins in Peroxisomal Import by Walton, Paul A., Wendland, Martin, Subramani, Suresh, Rachubinski, Richard A., Welch, William J.

“…This report describes the involvement of 70-kD heat-shock proteins (hsp70) in the import of proteins into mammalian peroxisomes. Employing a…”
Get full text

Transport of microinjected alcohol oxidase from Pichia pastoris into vesicles in mammalian cells: involvement of the peroxisomal targeting signal by Walton, P.A. (McGill University, Montreal, Quebec, Canada), Gould, S.J, Rachubinski, R.A, Subramani, S, Feramisco, J.R

“…This report describes the microinjection of a purified peroxisomal protein, alcohol oxidase, from Pichia pastoris into mammalian tissue culture cells and the…”
Get full text

Gα13 activation rescues moesin-depletion induced apoptosis in F9 teratocarcinoma cells by Krawetz, Roman, MacKenzie, Michael J., Sun, Qizhi, Walton, Paul A., Kelly, Gregory M.

“…Mouse F9 cells differentiate into primitive endoderm when treated with retinoic acid (RA) and into parietal endoderm in response to RA and dibutyryl (db-)…”
Get full text