Search Results - "Walton, Patrick"

Metal–Organic Frameworks for Drug Delivery: A Design Perspective by Lawson, Harrison D, Walton, S. Patrick, Chan, Christina

“…The use of metal–organic frameworks (MOFs) in biomedical applications has greatly expanded over the past decade due to the precision tunability, high surface…”
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Designing highly active siRNAs for therapeutic applications by Patrick Walton, S, Wu, Ming, Gredell, Joseph A, Chan, Christina

“…The discovery of RNA interference (RNAi) generated considerable interest in developing short interfering RNAs (siRNAs) for understanding basic biology and as…”
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Use of Brevibacillus choshinensis for the production of biologically active brain-derived neurotrophic factor (BDNF) by Angart, Phillip A., Carlson, Rebecca J., Thorwall, Sarah, Patrick Walton, S.

“…Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family critical for neuronal cell survival and differentiation, with therapeutic…”
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Using Singing and Movement to Teach Pre-reading Skills and Word Reading to Kindergarten Children: An Exploratory Study by Walton, Patrick

“…Kindergarten classrooms were randomly assigned to a songs group (n = 44) that used choral singing and movement to teach phonological skills, letter-sounds, and…”
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Instructional Supports for Motivation Trajectories in Introductory College Engineering by Robinson, Kristy A., Lira, Amalia Krystal, Walton, S. Patrick, Briedis, Daina, Linnenbrink-Garcia, Lisa

“…Students, instructors, and policy makers are in need of research-based recommendations for supporting students’ motivation to pursue STEM fields. The present…”
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Design of siRNA Therapeutics from the Molecular Scale by Angart, Phillip, Vocelle, Daniel, Chan, Christina, Walton, S Patrick

“…While protein-based therapeutics is well-established in the market, development of nucleic acid therapeutics has lagged. Short interfering RNAs (siRNAs)…”
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Kinetic analysis of the intracellular processing of siRNAs by confocal microscopy by Vocelle, Daniel, Chesniak, Olivia M, Smith, Milton R, Chan, Christina, Walton, S Patrick

“…Abstract Here, we describe a method for tracking intracellular processing of small interfering RNA (siRNA) containing complexes using automated microscopy…”
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Quantitative, solution-phase profiling of multiple transcription factors in parallel by Bilgin, Betul, Liu, Li, Chan, Christina, Walton, S. Patrick

“…Transcription factors are regulatory proteins that bind to specific sites of chromosomal DNA to enact responses to intracellular and extracellular stimuli…”
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Latest developments in experimental and computational approaches to characterize protein-lipid interactions by Cho, Hyunju, Wu, Ming, Bilgin, Betul, Walton, S. Patrick, Chan, Christina

“…Understanding the functional roles of all the molecules in cells is an ultimate goal of modern biology. An important facet is to understand the functional…”
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Impact of target mRNA structure on siRNA silencing efficiency: A large-scale study by Gredell, Joseph A, Berger, Angela K, Walton, S. Patrick

“…The selection of active siRNAs is generally based on identifying siRNAs with certain sequence and structural properties. However, the efficiency of RNA…”
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Brain derived neurotrophic factor release from layer-by-layer coated agarose nerve guidance scaffolds by Lynam, Daniel A., Shahriari, Dena, Wolf, Kayla J., Angart, Phillip A., Koffler, Jacob, Tuszynski, Mark H., Chan, Christina, Walton, Patrick, Sakamoto, Jeffrey

“…[Display omitted] Agarose nerve guidance scaffolds (NGS) seeded with cells expressing brain derived neurotrophic factor (BDNF) have demonstrated robust nerve…”
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Engineering active siRNA therapeutics by Patrick Walton, S.

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Recognition of siRNA Asymmetry by TAR RNA Binding Protein by Gredell, Joseph A, Dittmer, Michael J, Wu, Ming, Chan, Christina, Walton, S. Patrick

“…The recognition of small interfering RNAs (siRNAs) by the RNA-induced silencing complex (RISC) and its precursor, the RISC loading complex (RLC), is a key step…”
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Synergy analysis reveals association between insulin signaling and desmoplakin expression in palmitate treated HepG2 cells by Wang, Xuewei, Nath, Aritro, Yang, Xuerui, Portis, Amanda, Walton, S Patrick, Chan, Christina

“…The regulation of complex cellular activities in palmitate treated HepG2 cells, and the ensuing cytotoxic phenotype, involves cooperative interactions between…”
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Motivation in Transition: Development and Roles of Expectancy, Task Values, and Costs in Early College Engineering by Robinson, Kristy A, Lee, You-kyung, Bovee, Emily A, Perez, Tony, Walton, S. Patrick, Briedis, Daina, Linnenbrink-Garcia, Lisa

“…This longitudinal study investigated development in expectancy for success (perceived competence), 3 types of task value (utility, interest, attainment), and 3…”
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The role of endoplasmic reticulum stress on reducing recombinant protein production in mammalian cells by Splichal, R. Chauncey, Chen, Kevin, Walton, S. Patrick, Chan, Christina

“…Therapeutic recombinant protein production relies on industrial scale culture of mammalian cells to produce active proteins in quantities sufficient for…”
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Decolonizing field education by Clark, Natalie, Drolet, Julie, Mathews, Nadine, Walton, Patrick, Tamburro, Paul Rene’, Derrick, Jann, Michaud, Vicki, Armstrong, Joanne, Arnouse, Mike

“…This article shares our reflections and learning on decolonizing field education programs based on exploratory research in the Interior of British Columbia…”
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Endocytosis Controls siRNA Efficiency: Implications for siRNA Delivery Vehicle Design and Cell-Specific Targeting by Vocelle, Daniel, Chan, Christina, Walton, S Patrick

“…While small interfering RNAs (siRNAs) are commonly used for laboratory studies, development of siRNA therapeutics has been slower than expected, due, in part,…”
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In vitro binding of single-stranded RNA by human Dicer by Kini, Hemant K., Walton, S. Patrick

“…While Dicer alone has been shown to form stable complexes with double-stranded RNAs and short interfering RNAs, its interactions with single-stranded RNAs…”
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Thermodynamic and Kinetic Characterization of Antisense Oligodeoxynucleotide Binding to a Structured mRNA by Walton, S. Patrick, Stephanopoulos, Gregory N., Yarmush, Martin L., Roth, Charles M.

“…Antisense oligonucleotides act as exogenous inhibitors of gene expression by binding to a complementary sequence on the target mRNA, preventing translation…”
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