Search Results - "Walton, H S"

CYP1A2 Is Essential in Murine Uroporphyria Caused by Hexachlorobenzene and Iron by Sinclair, Peter R., Gorman, Nadia, Walton, Heidi S., Bement, William J., Dalton, Timothy P., Sinclair, Jacqueline F., Smith, Andrew G., Nebert, Daniel W.

“…Using Cyp1a2(−/−) mice we previously showed that CYP1A2 is absolutely required for hepatic uroporphyrin accumulation caused by iron and 5-aminolevulinate (ALA)…”
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Uroporphyrinogen Oxidation Catalyzed by Human Cytochromes P450 by SINCLAIR, P. R, GORMAN, N, TSYRLOV, I. B, FUHR, U, WALTON, H. S, SINCLAIR, J. F

“…Porphyria cutanea tarda is associated with excess hepatic production of uroporphyrin. Oxidation of uroporphyrinogen to uroporphyrin was previously demonstrated…”
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Identification of CYP1A5 as the CYP1A Enzyme Mainly Responsible for Uroporphyrinogen Oxidation Induced by Ah Receptor Ligands in Chicken Liver and Kidney by SINCLAIR, P. R, GORMAN, N, WALTON, H. S, SINCLAIR, J. F, LEE, C. A, RIFKIND, A. B

“…Uroporphyrinogen is an intermediate of the heme biosynthetic pathway. The oxidation of uroporphyrinogen to uroporphyrin (UROX) has been demonstrated to be…”
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Role of small differences in CYP1A2 in the development of uroporphyria produced by iron and 5-aminolevulinate in C57BL/6 and SWR strains of mice by Gorman, Nadia, Walton, Heidi S, Bement, William J, Honsinger, Charles P, Szakacs, Juliana G, Sinclair, Jacqueline F, Sinclair, Peter R

“…Previous work has implicated CYP1A2 in experimental uroporphyria caused by polyhalogenated aromatic compounds, and in uroporphyria caused by iron and…”
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Multiple Roles of Polyhalogenated Biphenyls in Causing Increases in Cytochrome P450 and Uroporphyrin Accumulation in Cultured Hepatocytes by Sinclair, Peter R., Walton, Heidi S., Gorman, Nadia, Jacobs, Judith M., Sinclair, Jacqueline F.

“…Uroporphyrin (URO) accumulation occurs in chick embryo hepatocytes treated with a number of polyhalogenated aromatic hydrocarbons (PHAHs) that are known…”
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Formation of zinc protoporphyrin in cultured hepatocytes: effects of ferrochelatase inhibition, iron chelation or lead by Jacobs, Judith M, Sinclair, Peter R, Sinclair, Jacqueline F, Gorman, Nadia, Walton, Heidi S, Wood, Sheryl G, Nichols, Calen

“…The formation of zinc protoporphyrin in response to lead or iron depletion has previously been investigated in erythroid systems. Because of its possible…”
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Ascorbic acid inhibits chemically induced uroporphyria in ascorbate-requiring rats by Sinclair, P R, Gorman, N, Sinclair, J F, Walton, H S, Bement, W J, Lambrecht, R W

“…Ascorbate was previously shown to suppress accumulation of uroporphyrin (URO) in cultured chick embryo hepatocytes and to competitively inhibit microsomal…”
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Ascorbic acid inhibition of cytochrome P450-catalyzed uroporphyrin accumulation by Sinclair, P R, Gorman, N, Walton, H S, Bement, W J, Jacobs, J M, Sinclair, J F

“…Previous studies on the mechanism of the uroporphyria caused by polyhalogenated aromatic hydrocarbons have indicated a key role of cytochrome P450 of the 1A…”
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Release of Cr(III) from Cr(III) picolinate upon metabolic activation by Kareus, Seth A, Kelley, Colleen, Walton, Heidi S, Sinclair, Peter R

“…Hexavalent and trivalent chromium are released into the environment from a number of different industrial activities. It is known that Cr(VI) can be reduced…”
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Cocaine toxicity in cultured chicken hepatocytes: role of cytochrome P450 by LeDuc, B W, Sinclair, P R, Walton, H S, Sinclair, J F, Greenblatt, D J, Shuster, L

“…Cocaine (COC) causes liver damage in several species, including man. Chicken embryo hepatocyte cultures were evaluated as a model system to investigate the…”
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Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice by Sinclair, P R, Gorman, N, Dalton, T, Walton, H S, Bement, W J, Sinclair, J F, Smith, A G, Nebert, D W

“…In the present study we have investigated the putative requirement for the cytochrome P-450 isoform CYP1A2 in murine uroporphyria, by comparing Cyp1a2(-/-)…”
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Uroporphyria in Hfe mutant mice given 5-aminolevulinate: A new model of Fe-mediated porphyria cutanea tarda by Sinclair, Peter R., Gorman, Nadia, Walton, Heidi S., Bement, William J., Sinclair, Jacqueline F., Gerhard, Glenn S., Szakacs, Juliana G., Andrews, Nancy C., Levy, Joanne E.

“…Porphyria cutanea tarda (PCT), a liver disease with skin lesions caused by excess liver production of uroporphyrin (URO), is associated with consumption of…”
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Short-term Treatment with Alcohols Causes Hepatic Steatosis and Enhances Acetaminophen Hepatotoxicity in Cyp2e1(-/-) Mice by Sinclair, Jacqueline F., Szakacs, Juliana G., Wood, Sheryl G., Walton, Heidi S., Bement, Jenna L., Gonzalez, Frank J., Jeffery, Elizabeth H., Wrighton, Steven A., Bement, William J., Sinclair, Peter R.

“…CYP2E1 has been reported to have an essential role in alcohol-mediated increases in hepatic steatosis and acetaminophen hepatotoxicity. We found that…”
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Effect of Arsenite on the Induction of CYP1A4 and CYP1A5 in Cultured Chick Embryo Hepatocytes by Jacobs, Judith M., Nichols, Calen, Marek, Doreen, Gorman, Nadia, Walton, Heidi S., Sinclair, Peter R., Sinclair, Jacqueline F.

“…We had reported previously that 2.5–5 μM sodium arsenite decreased the phenobarbital-mediated induction of CYP2H activity and protein but not CYP2H1 mRNA in…”
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Relative Roles of CYP2E1 and CYP1A2 in Mouse Uroporphyria Caused by Acetone by Sinclair, Peter R., Gorman, Nadia, Walton, Heidi S., Bement, William J., Szakacs, Juliana, Gonzalez, Frank J., Dalton, Timothy P., Nebert, Daniel W., Sinclair, Jacqueline F.

“…Porphyria cutanea tarda is a liver disease characterized by excess production of uroporphyrin. We previously reported that acetone, an inducer of CYP2E1,…”
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Effect of Sodium Arsenite on Heme Metabolism in Cultured Chick Embryo Hepatocytes by Jacobs, Judith M., Marek, Doreen, Walton, Heidi S., Sinclair, Peter R., Sinclair, Jacqueline F.

“…We had previously reported that low concentrations of sodium arsenite (1–5 μM) decreased the induction of cytochrome P450 CYP1A and CYP2H in cultured chick…”
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CYP1A-catalyzed uroporphyrinogen oxidation in hepatic microsomes from non-mammalian vertebrates (chick and duck embryos, scup and alligator) by Gorman, Nadia, Walton, Heidi S., Sinclair, Jacqueline F., Sinclair, Peter R.

“…Uroporphyrin (URO) accumulation in the liver of animals treated with polyhalogenated aromatic hydrocarbons (PHAH) is associated with increased microsomal…”
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Mechanism of the Synergistic Induction of CYP2H by Isopentanol plus Ethanol: Comparison to Glutethimide and Relation to Induction of 5-Aminolevulinate Synthase by Louis, Claudine A., Wood, Sheryl G., Walton, Heidi S., Sinclair, Peter R., Sinclair, Jacqueline F.

“…We had previously found that combined treatment with isopentanol and ethanol synergistically induced CYP2H protein and activity in cultured chick nepatoytes…”
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Protoporphyrinogen accumulation in cultured hepatocytes treated with the diphenyl ether herbicide, acifluorfen by Sinclair, P R, Gorman, N, Walton, H S, Sinclair, J F, Jacobs, J M, Jacobs, N J

“…Diphenyl ether (DPE) herbicides such as acifluorfen inhibit both the plant and mammalian forms of protoporphyrinogen oxidase, a heme biosynthetic enzyme. Only…”
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Uroporphyria in mice: Thresholds for hepatic CYP1A2 and iron by Gorman, Nadia, Ross, Kerry L., Walton, Heidi S., Bement, William J., Szakacs, Juliana G., Gerhard, Glenn S., Dalton, Timothy P., Nebert, Daniel W., Eisenstein, Richard S., Sinclair, Jacqueline F., Sinclair, Peter R.

“…In mice treated with 5-aminolevulinic acid (ALA) and polyhalogenated aromatic compounds, the levels of both hepatic cytochrome P450 (CYP)1A2 and iron—which can…”
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