Search Results - "Walton, E"

What Is the Relationship between Dopamine and Effort? by Walton, Mark E., Bouret, Sebastien

“…The trade-off between reward and effort is at the heart of most behavioral theories, from ecology to economics. Compared to reward, however, effort remains…”
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Frontal Cortex and Reward-Guided Learning and Decision-Making by Rushworth, Matthew F.S., Noonan, MaryAnn P., Boorman, Erie D., Walton, Mark E., Behrens, Timothy E.

“…Reward-guided decision-making and learning depends on distributed neural circuits with many components. Here we focus on recent evidence that suggests four…”
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The Role of the Gut Microbiota in Colorectal Cancer Causation by Alhinai, Eiman A, Walton, Gemma E, Commane, Daniel M

“…Here, we reviewed emerging evidence on the role of the microbial community in colorectal carcinogenesis. A healthy gut microbiota promotes intestinal…”
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MYC, Metabolism, and Cancer by Stine, Zachary E, Walton, Zandra E, Altman, Brian J, Hsieh, Annie L, Dang, Chi V

“…The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its precise oncogenic role enigmatically elusive. The evidence to date suggests…”
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Patterns of Mean-Level Change in Personality Traits Across the Life Course: A Meta-Analysis of Longitudinal Studies by Roberts, Brent W, Walton, Kate E, Viechtbauer, Wolfgang

“…The present study used meta-analytic techniques (number of samples = 92) to determine the patterns of mean-level change in personality traits across the life…”
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MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis by Cazarin, Juliana, DeRollo, Rachel E, Shahidan, Siti Noor Ain Binti Ahmad, Burchett, Jamison B, Mwangi, Daniel, Krishnaiah, Saikumari, Hsieh, Annie L, Walton, Zandra E, Brooks, Rebekah, Mello, Stephano S, Weljie, Aalim M, Dang, Chi V, Altman, Brian J

“…The molecular circadian clock, which controls rhythmic 24-hour oscillation of genes, proteins, and metabolites in healthy tissues, is disrupted across many…”
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Epigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study by Walton, E, Pingault, J -B, Cecil, C A M, Gaunt, T R, Relton, C L, Mill, J, Barker, E D

“…Attention-deficit/hyperactivity disorder (ADHD) is a prevalent developmental disorder, associated with a range of long-term impairments. Variation in DNA…”
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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR by Walton, Zandra E., Patel, Chirag H., Brooks, Rebekah C., Yu, Yongjun, Ibrahim-Hashim, Arig, Riddle, Malini, Porcu, Alessandra, Jiang, Tianying, Ecker, Brett L., Tameire, Feven, Koumenis, Constantinos, Weeraratna, Ashani T., Welsh, David K., Gillies, Robert, Alwine, James C., Zhang, Lin, Powell, Jonathan D., Dang, Chi V.

“…Recent reports indicate that hypoxia influences the circadian clock through the transcriptional activities of hypoxia-inducible factors (HIFs) at clock genes…”
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Fructose-1,6-bisphosphatase opposes renal carcinoma progression by Li, Bo, Qiu, Bo, Lee, David S. M., Walton, Zandra E., Ochocki, Joshua D., Mathew, Lijoy K., Mancuso, Anthony, Gade, Terence P. F., Keith, Brian, Nissim, Itzhak, Simon, M. Celeste

“…Fructose-1,6-bisphosphatase is shown to be depleted in clear cell renal cell carcinoma (ccRCC) and inhibits ccRCC progression by antagonizing glycolytic flux…”
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Action initiation shapes mesolimbic dopamine encoding of future rewards by Syed, Emilie C J, Grima, Laura L, Magill, Peter J, Bogacz, Rafal, Brown, Peter, Walton, Mark E

“…Mesolimbic dopamine has been implicated both in reward prediction and in promoting movement. This study demonstrates that the patterns of dopamine release in…”
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An In Vitro Approach to Study Effects of Prebiotics and Probiotics on the Faecal Microbiota and Selected Immune Parameters Relevant to the Elderly by Liu, Yue, Gibson, Glenn R, Walton, Gemma E

“…The aging process leads to alterations of gut microbiota and modifications to the immune response, such changes may be associated with increased disease risk…”
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Contrasting Roles for Orbitofrontal Cortex and Amygdala in Credit Assignment and Learning in Macaques by Chau, Bolton K.H., Sallet, Jérôme, Papageorgiou, Georgios K., Noonan, MaryAnn P., Bell, Andrew H., Walton, Mark E., Rushworth, Matthew F.S.

“…Recent studies have challenged the view that orbitofrontal cortex (OFC) and amygdala mediate flexible reward-guided behavior. We trained macaques to perform an…”
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Lights, fiber, action! A primer on in vivo fiber photometry by Simpson, Eleanor H, Akam, Thomas, Patriarchi, Tommaso, Blanco-Pozo, Marta, Burgeno, Lauren M, Mohebi, Ali, Cragg, Stephanie J, Walton, Mark E

“…Fiber photometry is a key technique for characterizing brain-behavior relationships in vivo. Initially, it was primarily used to report calcium dynamics as a…”
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Separate value comparison and learning mechanisms in macaque medial and lateral orbitofrontal cortex by Noonan, M. P., Walton, M. E., Behrens, T. E. J., Sallet, J., Buckley, M. J., Rushworth, M. F. S., Newsome, William T.

“…Uncertainty about the function of orbitofrontal cortex (OFC) in guiding decision-making may be a result of its medial (mOFC) and lateral (lOFC) divisions…”
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Learning the value of information in an uncertain world by Woolrich, Mark W, Behrens, Timothy E J, Walton, Mark E, Rushworth, Matthew F S

“…Our decisions are guided by outcomes that are associated with decisions made in the past. However, the amount of influence each past outcome has on our next…”
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Decision Making and Reward in Frontal Cortex: Complementary Evidence From Neurophysiological and Neuropsychological Studies by Kennerley, Steven W, Walton, Mark E

“…Patients with damage to the prefrontal cortex (PFC)-especially the ventral and medial parts of PFC-often show a marked inability to make choices that meet…”
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Re-evaluating the role of the orbitofrontal cortex in reward and reinforcement by Noonan, M. P., Kolling, N., Walton, M. E., Rushworth, M. F. S.

“…The orbitofrontal cortex and adjacent ventromedial prefrontal cortex carry reward representations and mediate flexible behaviour when circumstances change…”
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Systematic Review of the Effects of Exercise and Physical Activity on the Gut Microbiome of Older Adults by Ramos, Catarina, Gibson, Glenn R, Walton, Gemma E, Magistro, Daniele, Kinnear, Will, Hunter, Kirsty

“…Recent evidence suggests that exercise/physical activity (PA) can beneficially alter the gut microbiome composition of young people, but little is known about…”
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Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis by Lau, Allison N, Curtis, Stephen J, Fillmore, Christine M, Rowbotham, Samuel P, Mohseni, Morvarid, Wagner, Darcy E, Beede, Alexander M, Montoro, Daniel T, Sinkevicius, Kerstin W, Walton, Zandra E, Barrios, Juliana, Weiss, Daniel J, Camargo, Fernando D, Wong, Kwok-Kin, Kim, Carla F

“…Metastasis is the leading cause of morbidity for lung cancer patients. Here we demonstrate that murine tumor propagating cells (TPCs) with the markers Sca1 and…”
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Complementary task representations in hippocampus and prefrontal cortex for generalizing the structure of problems by Samborska, Veronika, Butler, James L., Walton, Mark E., Behrens, Timothy E. J., Akam, Thomas

“…Humans and other animals effortlessly generalize prior knowledge to solve novel problems, by abstracting common structure and mapping it onto new sensorimotor…”
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