Search Results - "Waltham, C"

A new silicon tracker for proton imaging and dosimetry by Taylor, J.T., Waltham, C., Price, T., Allinson, N.M., Allport, P.P., Casse, G.L., Kacperek, A., Manger, S., Smith, N.A., Tsurin, I.

“…For many years, silicon micro-strip detectors have been successfully used as tracking detectors for particle and nuclear physics experiments. A new application…”
Get full text

An experimental demonstration of a new type of proton computed tomography using a novel silicon tracking detector by Taylor, J. T., Poludniowski, G., Price, T., Waltham, C., Allport, P. P., Casse, G. L., Esposito, M., Evans, P. M., Green, S., Manger, S., Manolopoulos, S., Nieto-Camero, J., Parker, D. J., Symons, J., Allinson, N. M.

“…Purpose: Radiography and tomography using proton beams promise benefit to image guidance and treatment planning for proton therapy. A novel proton tracking…”
Get full text

The heat shock protein 90 inhibitor, 17-allylamino-17- demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line by PRICE, John T, QUINN, Julian M. W, THOMPSON, Erik W, SIMS, Natalie A, VIEUSSEUX, Jessica, WALDECK, Kelly, DOCHERTY, Susan E, MYERS, Damian, NAKAMURA, Akira, WALTHAM, Mark C, GILLESPIE, Matthew T

“…Breast cancer metastasis to the bone occurs frequently, causing numerous complications including severe pain, fracture, hypercalcemia, and paralysis. Despite…”
Get full text

Epidermal Growth Factor-Induced Epithelio-Mesenchymal Transition in Human Breast Carcinoma Cells by Ackland, Margaret L, Newgreen, Donald F, Fridman, Masha, Waltham, Mark C, Arvanitis, Angela, Minichiello, Joseph, Price, John T, Thompson, Erik W

“…PMC42-LA cells display an epithelial phenotype: the cells congregate into pavement epithelial sheets in which E-cadherin and β-catenin are localized at…”
Get full text

Bearing capacity of rock over mined cavities in Nottingham by Waltham, A.C, Swift, G.M

“…A significant geohazard is created in Nottingham, UK, by hundreds of man-made caves cut in the weak sandstone beneath the city centre. Stability of the caves…”
Get full text

Dihydrofolate Reductase Protein Inhibits Its Own Translation by Binding to Dihydrofolate Reductase mRNA Sequences within the Coding Region by Ercikan-Abali, Emine A, Banerjee, Debabrata, Waltham, Mark C, Skacel, Nancy, Scotto, Kathleen W, Bertino, Joseph R

“…Previous studies suggest that dihydrofolate reductase (DHFR) regulates its own translation. Moreover, intracellular levels of DHFR protein increase following…”
Get full text

Roads over lava tubes in Cheju Island, South Korea by Waltham, A.C, Park, H.D

“…There are 59 known lava tubes in the basalts of Cheju Island, South Korea. They have formed by either crusting or injection, and the structural properties of…”
Get full text

Active site-directed double mutants of dihydrofolate reductase by ERCIKAN-ABALI, E. A, MINEISHI, S, TONG, Y, NAKAHARA, S, WALTHAM, M. C, BANERJEE, D, CHEN, W, SADELAIN, M, BERTINO, J. R

“…Variants of dihydrofolate reductase (DHFR), which confer resistance to antifolates, are used as dominant selectable markers in vitro and in vivo and may be…”
Get full text

Methotrexate Resistance in an in vivo Mouse Tumor Due to a Non-Active-Site Dihydrofolate Reductase Mutation by Dicker, Adam P., Waltham, Mark C., Volkenandt, Matthias, Schweitzer, Barry I., Otter, Glenys M., Schmid, Franz a., Sirotnak, Francis M., Bertino, Joseph R.

“…A series of methotrexate (MTX)-resistant L1210 leukemia murine ascites tumors were developed in vivo and analyzed for drug resistance. Three of 20 tumors…”
Get full text

Sharing publication-related data and materials: responsibilities and authorship in the life sciences by Cech, Thomas R, Eddy, Sean R, Eisenberg, David, Hersey, Karen, Holtzman, Steven H, Poste, George H, Raikhel, Natasha V, Scheller, Richard H, Singer, David B, Waltham, Mary C

Get full text

Variants of human dihydrofolate reductase with substitutions at leucine-22: effect on catalytic and inhibitor binding properties by Ercikan-Abali, E A, Waltham, M C, Dicker, A P, Schweitzer, B I, Gritsman, H, Banerjee, D, Bertino, J R

“…We investigated the enzyme kinetic and antifolate inhibitory properties of human dihydrofolate reductase enzyme with mutations at position 22. Leu-22 was…”
Get more information

PRaVDA: The first solid-state system for proton computed tomography by Esposito, Michela, Waltham, Chris, Taylor, Jonathan T., Manger, Sam, Phoenix, Ben, Price, Tony, Poludniowski, Gavin, Green, Stuart, Evans, Philip M., Allport, Philip P., Manolopulos, Spyros, Nieto-Camero, Jaime, Symons, Julyan, Allinson, Nigel M.

“…•A novel proton CT imaging system, based entirely on solid-state detector technology.•First proton CT scan with solid-state detectors.•Potential for short scan…”
Get full text

gamma-Glutamyl hydrolase from human sarcoma HT-1080 cells: characterization and inhibition by glutamine antagonists by Waltham, M C, Li, W W, Gritsman, H, Tong, W P, Bertino, J R

“…Elevated gamma-glutamyl hydrolase (GGH) activity as a contributing factor in mechanisms of acquired and intrinsic antifolate resistance has been reported for…”
Get more information

Vibro-acoustic characteristics of an Aoyama Amphion concert harp by Daltrop, Shira, Kotlicki, Andrzej, Waltham, Chris

“…The mechanical admittance of the soundboards of four full-size concert harps from three manufacturers was measured, and the results show that there is little…”
Get full text

MYOEPITHELIAL MOLECULAR MARKERS IN HUMAN BREAST CARCINOMA PMC42-LA CELLS ARE INDUCED BY EXTRACELLULAR MATRIX AND STROMAL CELLS by LEBRET, STEPHANIE C, NEWGREEN, DONALD F, WALTHAM, MARK C, PRICE, JOHN T, THOMPSON, ERIK W, ACKLAND, M. LEIGH

“…The microenvironment plays a key role in the cellular differentiation of the two main cell lineages of the human breast, luminal epithelial, and myoepithelial…”
Get full text

Teaching neutrino oscillations by Waltham, Chris

“…Neutrino oscillations are purely quantum mechanical effects that occur over macroscopic time and distance scales. I present the physics of this phenomenon in…”
Get full text

Mapping the vibroacoustic behavior of harp soundboxes by Daltrop, Shira, Kotlicki, Andrzej, Waltham, Chris

“…Modern harp soundboxes typically consist of a thin soundboard made of an acoustic wood with a definite set of resonances, and a relatively heavy conical or…”
Get full text

Light concentrators for the Sudbury Neutrino Observatory by Doucas, G., Gil, S., Jelley, N.A., McGarry, L., Moorhead, M.E., Tanner, N.W., Waltham, C.E.

“…There is an important and growing class of elementary particle detectors which are characterized by a large sensitive volume (thousands of tonnes), very low…”
Get full text

Direct experimental evidence for competitive inhibition of dihydrofolate reductase by methotrexate by Waltham, M C, Holland, J W, Robinson, S C, Winzor, D J, Nixon, P F

“…Steady-state enzyme kinetic techniques at very low enzyme concentration (0.4 nM) were used successfully to measure the inhibition constant (53 pM) for the…”
Get more information

Thermodynamic characterization of the interactions of methotrexate with dihydrofolate reductase by quantitative affinity chromatography by Waltham, M C, Holland, J W, Nixon, P F, Winzor, D J

“…Affinity chromatography on methotrexate-Sepharose has been used to evaluate dissociation constants for interactions of methotrexate with dihydrofolate…”
Get more information