Search Results - "Walters, James T"

Analysis of copy number variations at 15 schizophrenia-associated loci by REES, Elliott, WALTERS, James T. R, O'DONOVAN, Michael C, OWEN, Michael J, KIROV, George, GEORGIEVA, Lyudmila, ISLES, Anthony R, CHAMBERT, Kimberly D, RICHARDS, Alexander L, MAHONEY-DAVIES, Gerwyn, LEGGE, Sophie E, MORAN, Jennifer L, MCCARROLL, Steven A

“…A number of copy number variants (CNVs) have been suggested as susceptibility factors for schizophrenia. For some of these the data remain equivocal, and the…”
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Association of Antihypertensive Drug Target Genes With Psychiatric Disorders: A Mendelian Randomization Study by Chauquet, Solal, Zhu, Zhihong, O'Donovan, Michael C, Walters, James T R, Wray, Naomi R, Shah, Sonia

“…Observational studies have reported associations between antihypertensive medication and psychiatric disorders, although the reported direction of association…”
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Genetic identification of brain cell types underlying schizophrenia by Skene, Nathan G., Bryois, Julien, Bakken, Trygve E., Breen, Gerome, Crowley, James J., Gaspar, Héléna A., Giusti-Rodriguez, Paola, Hodge, Rebecca D., Miller, Jeremy A., Muñoz-Manchado, Ana B., O’Donovan, Michael C., Owen, Michael J., Pardiñas, Antonio F., Ryge, Jesper, Walters, James T. R., Linnarsson, Sten, Lein, Ed S., Sullivan, Patrick F., Hjerling-Leffler, Jens

“…With few exceptions, the marked advances in knowledge about the genetic basis of schizophrenia have not converged on findings that can be confidently used for…”
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Genomic findings in schizophrenia and their implications by Owen, Michael J., Legge, Sophie E., Rees, Elliott, Walters, James T. R., O’Donovan, Michael C.

“…There has been substantial progress in understanding the genetics of schizophrenia over the past 15 years. This has revealed a highly polygenic condition with…”
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Cis-effects on gene expression in the human prenatal brain associated with genetic risk for neuropsychiatric disorders by Hall, Lynsey S., Pain, Oliver, O’Brien, Heath E., Anney, Richard, Walters, James T. R., Owen, Michael J., O’Donovan, Michael C., Bray, Nicholas J.

“…The majority of common risk alleles identified for neuropsychiatric disorders reside in noncoding regions of the genome and are therefore likely to impact gene…”
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Analysis of Intellectual Disability Copy Number Variants for Association With Schizophrenia by Rees, Elliott, Kendall, Kimberley, Pardiñas, Antonio F, Legge, Sophie E, Pocklington, Andrew, Escott-Price, Valentina, MacCabe, James H, Collier, David A, Holmans, Peter, O'Donovan, Michael C, Owen, Michael J, Walters, James T R, Kirov, George

“…At least 11 rare copy number variants (CNVs) have been shown to be major risk factors for schizophrenia (SZ). These CNVs also increase the risk for other…”
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Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations by Rees, Elliott, Creeth, Hugo D. J., Hwu, Hai-Gwo, Chen, Wei J., Tsuang, Ming, Glatt, Stephen J., Rey, Romain, Kirov, George, Walters, James T. R., Holmans, Peter, Owen, Michael J., O’Donovan, Michael C.

“…People with schizophrenia are enriched for rare coding variants in genes associated with neurodevelopmental disorders, particularly autism spectrum disorders…”
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Association of Genetic Liability to Psychotic Experiences With Neuropsychotic Disorders and Traits by Legge, Sophie E, Jones, Hannah J, Kendall, Kimberley M, Pardiñas, Antonio F, Menzies, Georgina, Bracher-Smith, Matthew, Escott-Price, Valentina, Rees, Elliott, Davis, Katrina A S, Hotopf, Matthew, Savage, Jeanne E, Posthuma, Danielle, Holmans, Peter, Kirov, George, Owen, Michael J, O'Donovan, Michael C, Zammit, Stanley, Walters, James T R

“…Psychotic experiences, such as hallucinations and delusions, are reported by approximately 5% to 10% of the general population, although only a small…”
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Phenotypic Manifestation of Genetic Risk for Schizophrenia During Adolescence in the General Population by Jones, Hannah J, Stergiakouli, Evie, Tansey, Katherine E, Hubbard, Leon, Heron, Jon, Cannon, Mary, Holmans, Peter, Lewis, Glyn, Linden, David E J, Jones, Peter B, Davey Smith, George, O'Donovan, Michael C, Owen, Michael J, Walters, James T, Zammit, Stanley

“…Schizophrenia is a highly heritable, polygenic condition characterized by a relatively diverse phenotype and frequent comorbid conditions, such as anxiety and…”
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Associations Between Schizophrenia Polygenic Liability, Symptom Dimensions, and Cognitive Ability in Schizophrenia by Legge, Sophie E, Cardno, Alastair G, Allardyce, Judith, Dennison, Charlotte, Hubbard, Leon, Pardiñas, Antonio F, Richards, Alexander, Rees, Elliott, Di Florio, Arianna, Escott-Price, Valentina, Zammit, Stanley, Holmans, Peter, Owen, Michael J, O'Donovan, Michael C, Walters, James T R

“…Schizophrenia is a clinically heterogeneous disorder. It is currently unclear how variability in symptom dimensions and cognitive ability is associated with…”
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The Penetrance of Copy Number Variations for Schizophrenia and Developmental Delay by Kirov, George, Rees, Elliott, Walters, James T.R, Escott-Price, Valentina, Georgieva, Lyudmila, Richards, Alexander L, Chambert, Kimberly D, Davies, Gerwyn, Legge, Sophie E, Moran, Jennifer L, McCarroll, Steven A, O’Donovan, Michael C, Owen, Michael J

“…Background Several recurrent copy number variants (CNVs) have been shown to increase the risk of developing schizophrenia (SCZ), developmental delay (DD),…”
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Association Between Schizophrenia-Related Polygenic Liability and the Occurrence and Level of Mood-Incongruent Psychotic Symptoms in Bipolar Disorder by Allardyce, Judith, Leonenko, Ganna, Hamshere, Marian, Pardiñas, Antonio F, Forty, Liz, Knott, Sarah, Gordon-Smith, Katherine, Porteous, David J, Haywood, Caroline, Di Florio, Arianna, Jones, Lisa, McIntosh, Andrew M, Owen, Michael J, Holmans, Peter, Walters, James T R, Craddock, Nicholas, Jones, Ian, O'Donovan, Michael C, Escott-Price, Valentina

“…Bipolar disorder (BD) overlaps schizophrenia in its clinical presentation and genetic liability. Alternative approaches to patient stratification beyond…”
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De novo mutations identified by exome sequencing implicate rare missense variants in SLC6A1 in schizophrenia by Rees, Elliott, Han, Jun, Morgan, Joanne, Carrera, Noa, Escott-Price, Valentina, Pocklington, Andrew J., Duffield, Madeleine, Hall, Lynsey S., Legge, Sophie E., Pardiñas, Antonio F., Richards, Alexander L., Roth, Julian, Lezheiko, Tatyana, Kondratyev, Nikolay, Kaleda, Vasilii, Golimbet, Vera, Parellada, Mara, González-Peñas, Javier, Arango, Celso, Gawlik, Micha, Kirov, George, Walters, James T. R., Holmans, Peter, O’Donovan, Michael C., Owen, Michael J.

“…Schizophrenia is a highly polygenic disorder with important contributions from both common and rare risk alleles. We analyzed exome sequencing data for de novo…”
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Novel Findings from CNVs Implicate Inhibitory and Excitatory Signaling Complexes in Schizophrenia by Pocklington, Andrew J., Rees, Elliott, Walters, James T.R., Han, Jun, Kavanagh, David H., Chambert, Kimberly D., Holmans, Peter, Moran, Jennifer L., McCarroll, Steven A., Kirov, George, O’Donovan, Michael C., Owen, Michael J.

“…We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the association between the disorder and chromosomal copy number (CNV) burden…”
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A genome-wide association study in individuals of African ancestry reveals the importance of the Duffy-null genotype in the assessment of clozapine-related neutropenia by Legge, Sophie E., Pardiñas, Antonio F., Helthuis, Marinka, Jansen, John A., Jollie, Karel, Knapper, Steven, MacCabe, James H., Rujescu, Dan, Collier, David A., O’Donovan, Michael C., Owen, Michael J, Walters, James T. R.

“…Individuals of African ancestry in the United States and Europe are at increased risk of developing schizophrenia and have poorer clinical outcomes. The…”
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Genetic common variants associated with cerebellar volume and their overlap with mental disorders: a study on 33,265 individuals from the UK-Biobank by Chambers, Tom, Escott-Price, Valentina, Legge, Sophie, Baker, Emily, Singh, Krish D., Walters, James T. R., Caseras, Xavier, Anney, Richard J. L.

“…Interest in the cerebellum is expanding given evidence of its contributions to cognition and emotion, and dysfunction in various psychopathologies. However,…”
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Association of genetic liability for psychiatric disorders with accelerometer-assessed physical activity in the UK Biobank by Dennison, Charlotte A, Legge, Sophie E, Bracher-Smith, Matthew, Menzies, Georgina, Escott-Price, Valentina, Smith, Daniel J, Doherty, Aiden R, Owen, Michael J, O'Donovan, Michael C, Walters, James T R

“…Levels of activity are often affected in psychiatric disorders and can be core symptoms of illness. Advances in technology now allow the accurate assessment of…”
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Family-based analysis of the contribution of rare and common genetic variants to school performance in schizophrenia by Rammos, Alexandros, Kirov, George, Hubbard, Leon, Walters, James T. R., Holmans, Peter, Owen, Michael J., O’Donovan, Michael C., Rees, Elliott

“…Impaired cognition in schizophrenia is associated with worse functional outcomes. While genetic factors are known to contribute to variation in cognition in…”
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Gene set enrichment analysis of pathophysiological pathways highlights oxidative stress in psychosis by Pistis, Giorgio, Vázquez-Bourgon, Javier, Fournier, Margot, Jenni, Raoul, Cleusix, Martine, Papiol, Sergi, Smart, Sophie E., Pardiñas, Antonio F., Walters, James T. R., MacCabe, James H., Kutalik, Zoltán, Conus, Philippe, Crespo-Facorro, Benedicto, Q Do, Kim

“…Polygenic risk prediction remains an important aim of genetic association studies. Currently, the predictive power of schizophrenia polygenic risk scores…”
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Cognitive performance and functional outcomes of carriers of pathogenic copy number variants: analysis of the UK Biobank by Kendall, Kimberley M., Bracher-Smith, Matthew, Fitzpatrick, Harry, Lynham, Amy, Rees, Elliott, Escott-Price, Valentina, Owen, Michael J., O'Donovan, Michael C., Walters, James T.R., Kirov, George

“…Rare copy number variants (CNVs) are associated with risk of neurodevelopmental disorders characterised by varying degrees of cognitive impairment, including…”
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