Search Results - "Walters, D K"

The ageing human B cell repertoire: a failure of selection? by Dunn‐Walters, D. K.

“…Summary B cells undergo a number of different developmental stages, from initial formation of their B cell receptor (BCR) genes to differentiation into…”
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Evidence for ongoing DNA damage in multiple myeloma cells as revealed by constitutive phosphorylation of H2AX by Walters, D K, Wu, X, Tschumper, R C, Arendt, B K, Huddleston, P M, Henderson, K J, Dispenzieri, A, Jelinek, D F

“…DNA double-strand breaks (DSBs) are deleterious lesions that can lead to chromosomal anomalies, genomic instability and cancer. The histone protein H2AX has an…”
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Increased expression of extracellular matrix metalloproteinase inducer (CD147) in multiple myeloma: role in regulation of myeloma cell proliferation by Arendt, B K, Walters, D K, Wu, X, Tschumper, R C, Huddleston, P M, Henderson, K J, Dispenzieri, A, Jelinek, D F

“…Multiple myeloma (MM) is preceded by the asymptomatic pre-malignant state, monoclonal gammopathy of undetermined significance (MGUS). Although MGUS patients…”
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Dynamic coefficient evaluation for an algebraic subgrid stress model by Bhushan, S., Walters, D.K.

“…SUMMARYStatic model coefficients for an algebraic subgrid stress (SGS) model are determined using a dynamic approach, based on results from simulations of…”
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Mathematical analysis of antigen selection in somatically mutated immunoglobulin genes associated with autoimmunity by MacDonald, CM, Boursier, L., D'Cruz, DP, Dunn-Walters, DK, Spencer, J.

“…Affinity maturation is a process by which low-affinity antibodies are transformed into highly specific antibodies in germinal centres. This process occurs by…”
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Assessment of low- and high-fidelity turbulence models for heat transfer predictions in low-prandlt number flows by Bhushan, S., Elmellouki, M., Jamal, T., Busco, G., Walters, D.K., Hassan, Y.A., Merzari, E., Obabko, A.

“…•Comparison of RANS, hybrid RANS/LES and LES model predictions for canonical mixed convective flows.•Comparison of the predictive capability of turbulence…”
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Construction of a hybrid lung model by combining a real geometry of the upper airways and an idealized geometry of the lower airways by Agujetas, R., Barrio-Perotti, R., Ferrera, C., Pandal-Blanco, A., Walters, D.K., Fernández-Tena, A.

“…•A hybrid model of the human lung airway has been constructed using images obtained from computed tomography (CT) and an idealized morphology.•An intermediate…”
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Evaluation of hybrid RANS/LES models for prediction of flow around surface combatant and Suboff geometries by Bhushan, S., Alam, M.F., Walters, D.K.

“…•Application of recently developed hybrid RANS/LES (DHRL) model for ship flows.•URANS, DES and DHRL predictions are compared for appended DARPA Suboff.•DHRL…”
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Related IgA1 and IgG producing cells in blood and diseased mucosa in ulcerative colitis by Thoree, V C, Golby, S J C, Boursier, L, Hackett, M, Dunn-Walters, D K, Sanderson, J D, Spencer, J

“…Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which the colonic mucosa is infiltrated with plasma cells producing IgG…”
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Vitamin D concentration, body mass index, ethnicity and SARS-CoV-2/COVID-19: initial analysis of the first- reported UK Biobank Cohort positive cases (n 1474) compared with negative controls (n 4643) by Darling, A.L., Ahmadi, K. R., Ward, K.A., Harvey, N.C., Alves, A. Couto, Dunn-Walters, D. K., Lanham-New, S.A., Cooper, C., Blackbourn, D.J.

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Analysis of turbulent flow and thermal structures in low-Prandtl number buoyant flows using direct numerical simulations by Bhushan, S., Elmellouki, M., Walters, D.K., Hassan, Y.A., Merzari, E., Obabko, A.

“…•DNS database for low-Pr flows involving mixed aiding and opposing buoyant flow conditions.•Effect of Re, Pr, and buoyancy on the turbulent flow field and…”
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Numerical simulations of flow pattern and particle trajectories in feline aorta for hypertrophic cardiomyopathy heart conditions by Borse, M., Bhushan, S., Walters, D. K., Burgreen, G. W.

“…Numerical simulations of pulsatile flow in a feline aorta for hypertrophic cardiomyopathy (HCM) heart conditions are performed to predict flow details and to…”
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Boosting Techniques for Physics-Based Vortex Detection by Zhang, L., Deng, Q., Machiraju, R., Rangarajan, A., Thompson, D., Walters, D. K., Shen, H.-W.

“…Robust automated vortex detection algorithms are needed to facilitate the exploration of large‐scale turbulent fluid flow simulations. Unfortunately, robust…”
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Effects of age on antibody affinity maturation by Dunn-Walters, D K, Banerjee, M, Mehr, R

“…The elderly are more susceptible to infectious diseases. Mortality and morbidity from infections increase sharply over the age of 65 years. At the same time,…”
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Analytical model for electromagnetic induction in pulsating ferrofluid pipe flows by Wang, H., Monroe, J.G., Kumari, S., Leontsev, S.O., Vasquez, E.S., Thompson, S.M., Berg, M.J., Walters, D.K., Walters, K.B.

“…•Ferrofluidic induction is the generation of voltage via ferrofluid pulsation through a solenoid.•Developed analytical model predicts energy harvesting…”
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Salt-Lick–Induced Soil Disturbance in the Teton Wilderness, USA by Walters, D. K., DeLuca, T. H.

“…Manmade salt licks on public lands throughout the Rocky Mountain West have been created to attract large game for hunting purposes. This practice is both…”
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A novel chronic lymphocytic leukemia subset expressing mutated IGHV3-7-encoded rheumatoid factor B-cell receptors that are functionally proficient by Hoogeboom, R, Wormhoudt, T A, Schipperus, M R, Langerak, A W, Dunn-Walters, D K, Guikema, J E J, Bende, R J, van Noesel, C J M

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Analysis of immunoglobulin genes in splenic marginal zone lymphoma suggests ongoing mutation by Dunn-Walters, Deborah K., Boursier, Laurent, Spencer, J.O., Isaacson, Peter G.

“…Splenic marginal zone lymphoma (SMZL) is a low-grade primary splenic B cell lymphoma, originally thought to be related to splenic marginal zone B cells. Later…”
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B-cell lymphoma associated with chronic lymphatic leukaemia: two cases with contrasting aggressive and indolent behaviour by RATNAVEL, R.C., DUNN-WALTERS, D.K., BOURSIER, L., FRAZER-ANDREWS, E., ORCHARD, G., RUSSELL-JONES, R., CALONJE, E.

“…The term Richter's syndrome is used to describe the transformation of chronic lymphatic leukaemia (CLL) into a high‐grade systemic lymphoma and is associated…”
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Pemetrexed, a multitargeted antifolate drug, demonstrates lower efficacy in comparison to methotrexate against osteosarcoma cell lines by Bodmer, N., Walters, D.K., Fuchs, B.

“…The folate inhibitor methotrexate (MTX) is an important component of osteosarcoma (OS) treatment regimens. New generation multitargeted antifolates, such as…”
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