Search Results - "Walter, Thomas S."

Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability by Wang, Xiangxi, Li, Shi-Hua, Zhu, Ling, Nian, Qing-Gong, Yuan, Shuai, Gao, Qiang, Hu, Zhongyu, Ye, Qing, Li, Xiao-Feng, Xie, Dong-Yang, Shaw, Neil, Wang, Junzhi, Walter, Thomas S., Huiskonen, Juha T., Fry, Elizabeth E., Qin, Cheng-Feng, Stuart, David I., Rao, Zihe

“…Although several different flaviviruses may cause encephalitis, Japanese encephalitis virus is the most significant, being responsible for thousands of deaths…”
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A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71 by Wang, Xiangxi, Peng, Wei, Ren, Jingshan, Hu, Zhongyu, Xu, Jiwei, Lou, Zhiyong, Li, Xumei, Yin, Weidong, Shen, Xinliang, Porta, Claudine, Walter, Thomas S, Evans, Gwyndaf, Axford, Danny, Owen, Robin, Rowlands, David J, Wang, Junzhi, Stuart, David I, Fry, Elizabeth E, Rao, Zihe

“…Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease in children, but no vaccine or antiviral therapy is available. Structural analysis of…”
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Picornavirus uncoating intermediate captured in atomic detail by Ren, Jingshan, Wang, Xiangxi, Hu, Zhongyu, Gao, Qiang, Sun, Yao, Li, Xuemei, Porta, Claudine, Walter, Thomas S., Gilbert, Robert J., Zhao, Yuguang, Axford, Danny, Williams, Mark, McAuley, Katherine, Rowlands, David J., Yin, Weidong, Wang, Junzhi, Stuart, David I., Rao, Zihe, Fry, Elizabeth E.

“…It remains largely mysterious how the genomes of non-enveloped eukaryotic viruses are transferred across a membrane into the host cell. Picornaviruses are…”
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Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding by Walters, Lucy C., Harlos, Karl, Brackenridge, Simon, Rozbesky, Daniel, Barrett, Jordan R., Jain, Vitul, Walter, Thomas S., O’Callaghan, Chris A., Borrow, Persephone, Toebes, Mireille, Hansen, Scott G., Sacha, Jonah B, Abdulhaqq, Shaheed, Greene, Justin M., Früh, Klaus, Marshall, Emily, Picker, Louis J., Jones, E. Yvonne, McMichael, Andrew J., Gillespie, Geraldine M.

“…Through major histocompatibility complex class Ia leader sequence-derived (VL9) peptide binding and CD94/NKG2 receptor engagement, human leucocyte antigen E…”
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The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins by El Omari, Kamel, Li, Sai, Kotecha, Abhay, Walter, Thomas S., Bignon, Eduardo A., Harlos, Karl, Somerharju, Pentti, De Haas, Felix, Clare, Daniel K., Molin, Mika, Hurtado, Felipe, Li, Mengqiu, Grimes, Jonathan M., Bamford, Dennis H., Tischler, Nicole D., Huiskonen, Juha T., Stuart, David I., Roine, Elina

“…Lipid membrane fusion is an essential function in many biological processes. Detailed mechanisms of membrane fusion and the protein structures involved have…”
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Assembly of complex viruses exemplified by a halophilic euryarchaeal virus by De Colibus, Luigi, Roine, Elina, Walter, Thomas S., Ilca, Serban L., Wang, Xiangxi, Wang, Nan, Roseman, Alan M., Bamford, Dennis, Huiskonen, Juha T., Stuart, David I.

“…Many of the largest known viruses belong to the PRD1-adeno structural lineage characterised by conserved pseudo-hexameric capsomers composed of three copies of…”
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Crystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral Replication by ASSENBERG, René, MASTRANGELO, Eloise, WALTER, Thomas S, VERMA, Anil, MILANI, Mario, OWENS, Raymond J, STUART, David I, GRIMES, Jonathan M, MANCINI, Erika J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A plate-based high-throughput assay for virus stability and vaccine formulation by Walter, Thomas S., Ren, Jingshan, Tuthill, Tobias J., Rowlands, David J., Stuart, David I., Fry, Elizabeth E.

“…► A plate-based assay for virus measuring virus stability. ► Two fluorescent dyes measure independently but simultaneously capsid stability and capsid protein…”
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Structural and functional insights of RANKL-RANK interaction and signaling by Liu, Changzhen, Walter, Thomas S, Huang, Peng, Zhang, Shiqian, Zhu, Xuekai, Wu, Ying, Wedderburn, Lucy R, Tang, Peifu, Owens, Raymond J, Stuart, David I, Ren, Jingshan, Gao, Bin

“…Bone remodeling involves bone resorption by osteoclasts and synthesis by osteoblasts and is tightly regulated by the receptor activator of the NF-kappaB ligand…”
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Plate Tectonics of Virus Shell Assembly and Reorganization in Phage Φ8, a Distant Relative of Mammalian Reoviruses by El Omari, Kamel, Sutton, Geoff, Ravantti, Janne J., Zhang, Hanwen, Walter, Thomas S., Grimes, Jonathan M., Bamford, Dennis H., Stuart, David I., Mancini, Erika J.

“…The hallmark of a virus is its capsid, which harbors the viral genome and is formed from protein subunits, which assemble following precise geometric rules…”
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Lysine Methylation as a Routine Rescue Strategy for Protein Crystallization by Walter, Thomas S., Meier, Christoph, Assenberg, Rene, Au, Kin-Fai, Ren, Jingshan, Verma, Anil, Nettleship, Joanne E., Owens, Raymond J., Stuart, David I., Grimes, Jonathan M.

“…Crystallization remains a critical step in X-ray structure determination. Because it is not generally possible to rationally predict crystallization…”
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The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages by Altun, Mikael, Walter, Thomas S, Kramer, Holger B, Herr, Patrick, Iphöfer, Alexander, Boström, Johan, David, Yael, Komsany, Alia, Ternette, Nicola, Navon, Ami, Stuart, David I, Ren, Jingshan, Kessler, Benedikt M

“…Ovarian tumor domain containing proteases cleave ubiquitin (Ub) and ubiquitin-like polypeptides from proteins. Here we report the crystal structure of human…”
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Equine rhinitis A virus and its low pH empty particle: clues towards an aphthovirus entry mechanism? by Tuthill, Tobias J, Harlos, Karl, Walter, Thomas S, Knowles, Nick J, Groppelli, Elisabetta, Rowlands, David J, Stuart, David I, Fry, Elizabeth E

“…Equine rhinitis A virus (ERAV) is closely related to foot-and-mouth disease virus (FMDV), belonging to the genus Aphthovirus of the Picornaviridae. How…”
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Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding by Walters, Lucy C., Harlos, Karl, Brackenridge, Simon, Rozbesky, Daniel, Barrett, Jordan R., Jain, Vitul, Walter, Thomas S., O’Callaghan, Chris A., Borrow, Persephone, Toebes, Mireille, Hansen, Scott G., Sacha, Jonah B., Abdulhaqq, Shaheed, Greene, Justin M., Früh, Klaus, Marshall, Emily, Picker, Louis J., Jones, E. Yvonne, McMichael, Andrew J., Gillespie, Geraldine M.

“…The original version of this Article contained an error in the spelling of the author Jonah B Sacha, which was incorrectly given as Jonah Sacha. These errors…”
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A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization by Walter, Thomas S., Mayo, Chris J., Brown, James, Carter, Lester, Diprose, Jonathan M., Siebold, Christian, Pickford, Mike G., Sutton, Geoff C., Berrow, Nick S., Berry, Ian M., Stewart-Jones, Guillaume B. E., Grimes, Jonathan M., Stammers, David K., Jones, E. Yvonne, Esnouf, Robert M., Owens, Ray J., Stuart, David I., Harlos, Karl

“…Crystallization trials at the Division of Structural Biology in Oxford are now almost exclusively carried out using a high‐throughput workflow implemented in…”
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Structure of human Aichi virus and implications for receptor binding by Zhu, Ling, Wang, Xiangxi, Ren, Jingshan, Kotecha, Abhay, Walter, Thomas S., Yuan, Shuai, Yamashita, Teruo, Tuthill, Tobias J., Fry, Elizabeth E., Rao, Zihe, Stuart, David I.

“…Aichi virus (AiV), an unusual and poorly characterized picornavirus, classified in the genus Kobuvirus , can cause severe gastroenteritis and deaths in…”
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The Crystal Structure and Mutational Binding Analysis of the Extracellular Domain of the Platelet-activating Receptor CLEC-2 by Watson, Aleksandra A., Brown, James, Harlos, Karl, Eble, Johannes A., Walter, Thomas S., O'Callaghan, Christopher A.

“…The human C-type lectin-like molecule CLEC-2 is expressed on the surface of platelets and signaling through CLEC-2 causes platelet activation and aggregation…”
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High-Resolution Structure of the Catalytic Region of MICAL (Molecule Interacting with CasL), a Multidomain Flavoenzyme-Signaling Molecule by Siebold, Christian, Nick Berrow, Thomas S. Walter, Harlos, Karl, Ray J. Owens, Stuart, David I., Terman, Jonathan R., Kolodkin, Alex L., R. Jeroen Pasterkamp, Jones, E. Yvonne

“…Semaphorins are extracellular cell guidance cues that govern cytoskeletal dynamics during neuronal and vascular development. MICAL (molecule interacting with…”
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Towards rationalization of crystallization screening for small- to medium-sized academic laboratories: the PACT/JCSG+ strategy by Egan, David, Meged, Ran, Berry, Ian, Newman, Janet, Walter, Thomas S., Ben Jelloul, Marouane, Sussman, Joel L., Stuart, David I., Perrakis, Anastassis

“…A crystallization screening process is presented that was developed for a small academic laboratory. Its underlying concept is to combine sparse‐matrix…”
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A structural basis for antibody-mediated neutralization of Nipah virus reveals a site of vulnerability at the fusion glycoprotein apex by Avanzato, Victoria A., Oguntuyo, Kasopefoluwa Y., Escalera-Zamudio, Marina, Gutierrez, Bernardo, Golden, Michael, Pond, Sergei L. Kosakovsky, Pryce, Rhys, Walter, Thomas S., Seow, Jeffrey, Doores, Katie J., Pybus, Oliver G., Munster, Vincent J., Lee, Benhur, Bowden, Thomas A.

“…Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes frequent outbreaks of severe neurologic and respiratory disease in humans with high case…”
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