Search Results - "Walter, Scott A."

The Poincaré Pear and Poincaré-Darwin Fission Theory in Astrophysics, 1885-1901 by Walter, Scott A

“…In the early 1880s, Henri Poincaré discovered an equilibrium figure for uniformly-rotating fluid masses—the pear, or piriform figure—and speculated that in…”
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Chronic social stress Ameliorates psoriasiform dermatitis through upregulation of the Hypothalamic-Pituitary-Adrenal axis by Vegas, Oscar, Poligone, Brian, Blackcloud, Paul, Gilmore, Elaine S., VanBuskirk, JoAnne, Ritchlin, Christopher T., Pentland, Alice P., Walter, Scott A., Nousari, Yasmine, Tausk, Francisco

“…•Mice were genetically altered to develop a psoriasis-like disease by six weeks of age.•Exposure to chronic stress blocked the development of the psoriasiform…”
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HIV-1 infection is blocked at an early stage in cells devoid of mitochondrial DNA by Lu, Gaofei, Matsuura, Suzanne E, Barrientos, Antoni, Scott, Walter A

“…Human immunodeficiency virus type I (HIV-1) exploits various host cellular pathways for efficient infection. Here we report that the absence of mitochondrial…”
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Structures of reverse transcriptase pre- and post-excision complexes shed new light on HIV-1 AZT resistance by Scott, Walter A

“…HIV-1 resistance to 3'-azido-2',3'-deoxythymidine (AZT, zidovudine) results from mutations in reverse transcriptase that increase the ability of the enzyme to…”
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Unblocking of Chain-Terminated Primer by HIV-1 Reverse Transcriptase through a Nucleotide-Dependent Mechanism by Meyer, Peter R., Matsuura, Suzanne E., So, Antero G., Scott, Walter A.

“…HIV-1 replication is inhibited by the incorporation of chain-terminating nucleotides at the 3′end of the growing DNA chain. Here we show a nucleotide-dependent…”
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A Role of Template Cleavage in Reduced Excision of Chain-Terminating Nucleotides by Human Immunodeficiency Virus Type 1 Reverse Transcriptase Containing the M184V Mutation by Acosta-Hoyos, Antonio J., Matsuura, Suzanne E., Meyer, Peter R., Scott, Walter A.

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Interactions between HIV-1 reverse transcriptase and the downstream template strand in stable complexes with primer-template by Rutvisuttinunt, Wiriya, Meyer, Peter R, Scott, Walter A

“…Human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) forms stable ternary complexes in which RT is bound tightly at fixed positions on the…”
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The Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance by Acosta-Hoyos, Antonio J, Scott, Walter A

“…Nucleoside reverse transcriptase (RT) inhibitors of HIV block viral replication through the ability of HIV RT to incorporate chain-terminating nucleotide…”
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Differential Removal of Thymidine Nucleotide Analogues from Blocked DNA Chains by Human Immunodeficiency Virus Reverse Transcriptase in the Presence of Physiological Concentrations of 2′-Deoxynucleoside Triphosphates by MEYER, Peter R, MATSUURA, Suzanne E, SCHINAZI, Raymond F, SO, Antero G, SCOTT, Walter A

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Effects of Dipeptide Insertions between Codons 69 and 70 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Primer Unblocking, Deoxynucleoside Triphosphate Inhibition, and DNA Chain Elongation by Meyer, Peter R, Lennerstrand, Johan, Matsuura, Suzanne E, Larder, Brendan A, Scott, Walter A

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Chain-Terminating Dinucleoside Tetraphosphates Are Substrates for DNA Polymerization by Human Immunodeficiency Virus Type 1 Reverse Transcriptase with Increased Activity against Thymidine Analogue-Resistant Mutants by MEYER, Peter R, SMITH, Anthony J, MATSUURA, Suzanne E, SCOTT, Walter A

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Effects of Primer-Template Sequence on ATP-dependent Removal of Chain-terminating Nucleotide Analogues by HIV-1 Reverse Transcriptase by Meyer, Peter R, Smith, Anthony J, Matsuura, Suzanne E, Scott, Walter A

“…HIV-1 reverse transcriptase can remove chain terminators from blocked DNA ends through a nucleotide-dependent mechanism. We show that the catalytic efficiency…”
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Relationship between 3′-Azido-3′-Deoxythymidine Resistance and Primer Unblocking Activity in Foscarnet-Resistant Mutants of Human Immunodeficiency Virus Type 1 Reverse Transcriptase by Meyer, Peter R, Matsuura, Suzanne E, Zonarich, Dianna, Chopra, Rahul R, Pendarvis, Eric, Bazmi, Holly Z, Mellors, John W, Scott, Walter A

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Nucleocapsid Protein Precursors NCp9 and NCp15 Suppress ATP-Mediated Rescue of AZT-Terminated Primers by HIV-1 Reverse Transcriptase by Árquez, Moisés A, Martín-Alonso, Samara, Gorelick, Robert J, Scott, Walter A, Acosta-Hoyos, Antonio J, Menéndez-Arias, Luis

“…In HIV-1, development of resistance to AZT (3'-azido-3'-deoxythymidine) is mediated by the acquisition of thymidine analogue resistance mutations (TAMs) (i.e.,…”
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Effects of Specific Zidovudine Resistance Mutations and Substrate Structure on Nucleotide-Dependent Primer Unblocking by Human Immunodeficiency Virus Type 1 Reverse Transcriptase by MEYER, Peter R, MATSUURA, Suzanne E, TOLUN, Adviye A, PFEIFER, Ingrid, SO, Antero G, MELLORS, John W, SCOTT, Walter A

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Intracellular Substrates for the Primer-Unblocking Reaction by Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Detection and Quantitation in Extracts from Quiescent- and Activated-Lymphocyte Subpopulations by SMITH, Anthony J, MEYER, Peter R, ASTHANA, Deshratn, ASHMAN, Margarita R, SCOTT, Walter A

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A Mechanism of AZT Resistance: An Increase in Nucleotide-Dependent Primer Unblocking by Mutant HIV-1 Reverse Transcriptase by Meyer, Peter R, Matsuura, Suzanne E, Mian, A.Mohsin, So, Antero G, Scott, Walter A

“…Mutations in HIV-1 reverse transcriptase (RT) give rise to 3′-azido-3′-deoxythymidine (AZT) resistance by a mechanism that has not been previously reproduced…”
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Stable Complexes Formed by HIV-1 Reverse Transcriptase at Distinct Positions on the Primer-template Controlled by Binding Deoxynucleoside Triphosphates or Foscarnet by Meyer, Peter R., Rutvisuttinunt, Wiriya, Matsuura, Suzanne E., So, Antero G., Scott, Walter A.

“…Binding of the next complementary dNTP by the binary complex containing HIV-1 reverse transcriptase (RT) and primer-template induces conformational changes…”
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The Poincaré Pear and Poincaré-Darwin Fission Theory in Astrophysics, 1885-1901 by Scott A. Walter

“…In the early 1880s, Henri Poincaré discovered an equilibrium figure for uniformly-rotating fluid masses—the pear, or piriform figure—and speculated that in…”
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Nucleotide-Induced Stable Complex Formation by HIV-1 Reverse Transcriptase by Tong, Wenjing, Lu, Chang-De, Sharma, Satish K, Matsuura, Suzanne, So, Antero G, Scott, Walter A

“…Nondenaturing gel electrophoresis was used to study the nucleotide substrate-induced conformational change in reverse transcriptase (RT) of human…”
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