Search Results - "Walter, Mark R"

The Role of Structure in the Biology of Interferon Signaling by Walter, Mark R

“…Interferons (IFNs) are a family of cytokines with the unique ability to induce cell intrinsic programs that enhance resistance to viral infection. Induction of…”
Get full text

Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern by Deshpande, Ashlesha, Harris, Bethany D., Martinez-Sobrido, Luis, Kobie, James J., Walter, Mark R.

“…Severe acute respiratory syndrome coronavirus-2 (SAR-CoV-2) causes coronavirus disease 2019 (COVID19) that is responsible for short and long-term disease, as…”
Get full text

Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody by Piepenbrink, Michael S, Park, Jun-Gyu, Deshpande, Ashlesha, Loos, Andreas, Ye, Chengjin, Basu, Madhubanti, Sarkar, Sanghita, Khalil, Ahmed Magdy, Chauvin, David, Woo, Jennifer, Lovalenti, Philip, Erdmann, Nathaniel B, Goepfert, Paul A, Truong, Vu L, Bowen, Richard A, Walter, Mark R, Martinez-Sobrido, Luis, Kobie, James J

“…Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) marks the third novel β-coronavirus to cause significant human mortality in the last two decades…”
Get full text

Rapid in vitro assays for screening neutralizing antibodies and antivirals against SARS-CoV-2 by Park, Jun-Gyu, Oladunni, Fatai S., Chiem, Kevin, Ye, Chengjin, Pipenbrink, Michael, Moran, Thomas, Walter, Mark R., Kobie, James, Martinez-Sobrido, Luis

“…•We have developed a rapid, accurate, and highly reproducible plaque reduction microneutralization (PRMNT) assay for SARS-CoV-2.•Our PRMNT assay allows to…”
Get full text

Editorial: Structures, Signaling Mechanisms, and Functions of Types I and III Interferons by Rabin, Ronald L, Walter, Mark R

Get full text

Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines by Logsdon, Naomi J, Deshpande, Ashlesha, Harris, Bethany D, Rajashankar, Kanagalaghatta R, Walter, Mark R

“…Interleukin 20 (IL-20) is a pleotropic IL-10 family cytokine that protects epithelial surfaces from pathogens. However, dysregulated IL-20 signaling is…”
Get full text

Cytokine–receptor interactions as drug targets by Schreiber, Gideon, Walter, Mark R

“…Cytokines are essential proteins that exert potent control over entire cell populations to fight infections and other pathologies, but can by themselves cause…”
Get full text

Structure of IL-22 Bound to Its High-Affinity IL-22R1 Chain by Jones, Brandi C., Logsdon, Naomi J., Walter, Mark R.

“…IL-22 is an IL-10 family cytokine that initiates innate immune responses against bacterial pathogens and contributes to immune disease. IL-22 biological…”
Get full text

Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology by Streblow, Daniel N., Hirsch, Alec J., Stanton, Jeffrey J., Lewis, Anne D., Colgin, Lois, Hessell, Ann J., Kreklywich, Craig N., Smith, Jessica L., Sutton, William F., Chauvin, David, Woo, Jennifer, Bimber, Benjamin N., LeBlanc, Cierra N., Acharya, Sonia N., O’Roak, Brian J., Sardar, Harjinder, Sajadi, Mohammad M., Tehrani, Zahra R., Walter, Mark R., Martinez-Sobrido, Luis, Kobie, James J., Reader, Rachel J., Olstad, Katherine J., Hobbs, Theodore R., Saphire, Erica Ollmann, Schendel, Sharon L., Carnahan, Robert H., Knoch, Jonas, Branco, Luis M., Crowe, James E., Van Rompay, Koen K. A., Lovalenti, Phillip, Vu Truong, Forthal, Donald N., Haigwood, Nancy L.

“…Passively administered monoclonal antibodies (mAbs) given before or after viral infection can prevent or blunt disease. Here, we examine the efficacy of…”
Get full text

Conformational Changes Mediate Interleukin-10 Receptor 2 (IL-10R2) Binding to IL-10 and Assembly of the Signaling Complex by Yoon, Sung Il, Logsdon, Naomi J., Sheikh, Faruk, Donnelly, Raymond P., Walter, Mark R.

“…Interleukin-10 receptor 2 (IL-10R2) is a critical component of the IL-10·IL-10R1·IL-10R2 complex which regulates IL-10-mediated immunomodulatory responses. The…”
Get full text

Monitoring SARS-CoV-2 Infection Using a Double Reporter-Expressing Virus by Chiem, Kevin, Park, Jun-Gyu, Morales Vasquez, Desarey, Plemper, Richard K, Torrelles, Jordi B, Kobie, James J, Walter, Mark R, Ye, Chengjin, Martinez-Sobrido, Luis

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the highly contagious agent responsible for the coronavirus disease 2019 (COVID-19) pandemic…”
Get full text

Immunization with Recombinant Accessory Protein-Deficient SARS-CoV-2 Protects against Lethal Challenge and Viral Transmission by Ye, Chengjin, Park, Jun-Gyu, Chiem, Kevin, Dravid, Piyush, Allué-Guardia, Anna, Garcia-Vilanova, Andreu, Pino Tamayo, Paula, Shivanna, Vinay, Kapoor, Amit, Walter, Mark R, Kobie, James J, Plemper, Richard K, Torrelles, Jordi B, Martinez-Sobrido, Luis

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a worldwide coronavirus disease 2019 (COVID-19) pandemic. Despite the high efficacy of…”
Get full text

Vaccination against a Virus-Encoded Cytokine Significantly Restricts Viral Challenge by Eberhardt, Meghan K, Deshpande, Ashlesha, Chang, W L William, Barthold, Stephen W, Walter, Mark R, Barry, Peter A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys by Nelson, Cody S, Cruz, Diana Vera, Tran, Dollnovan, Bialas, Kristy M, Stamper, Lisa, Wu, Huali, Gilbert, Margaret, Blair, Robert, Alvarez, Xavier, Itell, Hannah, Chen, Meng, Deshpande, Ashlesha, Chiuppesi, Flavia, Wussow, Felix, Diamond, Don J, Vandergrift, Nathan, Walter, Mark R, Barry, Peter A, Cohen-Wolkowiez, Michael, Koelle, Katia, Kaur, Amitinder, Permar, Sallie R

“…Human cytomegalovirus (HCMV) is the most common congenital infection and a known cause of microcephaly, sensorineural hearing loss, and cognitive impairment…”
Get full text

Plasmablast Response to Primary Rhesus Cytomegalovirus (CMV) Infection in a Monkey Model of Congenital CMV Transmission by Fan, Qihua, Nelson, Cody S, Bialas, Kristy M, Chiuppesi, Flavia, Amos, Joshua, Gurley, Thaddeus C, Marshall, Dawn Jones, Eudailey, Joshua, Heimsath, Holly, Himes, Jonathon, Deshpande, Ashlesha, Walter, Mark R, Wussow, Felix, Diamond, Don J, Barry, Peter A, Moody, M Anthony, Kaur, Amitinder, Permar, Sallie R

“…Human cytomegalovirus (HCMV) is the most common congenital infection worldwide and the leading infectious cause of neurologic deficits and hearing loss in…”
Get full text

Potent neutralization by a RBD antibody with broad specificity for SARS-CoV-2 JN.1 and other variants by Piepenbrink, Michael S., Khalil, Ahmed Magdy, Chang, Ana, Mostafa, Ahmed, Basu, Madhubanti, Sarkar, Sanghita, Panjwani, Simran, Ha, Yaelyn H., Ma, Yao, Ye, Chengjin, Wang, Qian, Green, Todd J., Kizziah, James L., Erdmann, Nathaniel B., Goepfert, Paul A., Liu, Lihong, Ho, David D., Martinez-Sobrido, Luis, Walter, Mark R., Kobie, James J.

“…SARS-CoV-2 continues to be a public health burden, driven in-part by its continued antigenic diversification and resulting emergence of new variants. By…”
Get full text

Kinetic analysis of cytokine‐mediated receptor assembly using engineered FC heterodimers by Deshpande, Ashlesha, Putcha, Balananda‐Dhurjati Kumar, Kuruganti, Srilalitha, Walter, Mark R.

“…A method for analyzing ligand–receptor binding kinetics is described, which is based on an engineered FC domain (FChk) that forms a covalent heterodimer. To…”
Get full text

Unique aspects of mda-7/IL-24 antitumor bystander activity : establishing a role for secretion of MDA-7/IL-24 protein by normal cells by ZHAOZHONG SU, EMDAD, Luni, DENT, Paul, FISHER, Paul B, SAUANE, Moira, LEBEDEVA, Irina V, SARKAR, Devanand, GUPTA, Pankaj, JAMES, C. David, RANDOLPH, Aaron, VALERIE, Kirstoffer, WALTER, Mark R

“…Melanoma differentiation associated gene-7 (mda-7) was cloned using subtraction hybridization from terminally differentiated human melanoma cells. Based on…”
Get full text

The molecular basis of IL-10 function: from receptor structure to the onset of signaling by Walter, Mark R

“…Assembly of the cell surface IL-10 receptor complex is the first step in initiating IL-10 signaling pathways that regulate intestinal inflammation, viral…”
Get more information

Host immune responses to a viral immune modulating protein: immunogenicity of viral interleukin-10 in rhesus cytomegalovirus-infected rhesus macaques by Eberhardt, Meghan K, Chang, W L William, Logsdon, Naomi J, Yue, Yujuan, Walter, Mark R, Barry, Peter A

“…Considerable evidence has accumulated that multiple viruses, bacteria, and protozoa manipulate interleukin-10 (IL-10)-mediated signaling through the IL-10…”
Get full text