Search Results - "Walter, M.A."

Axenfeld‐Rieger syndrome by Seifi, M., Walter, M.A.

“…Axenfeld‐Rieger syndrome (ARS) is a clinically and genetically heterogeneous group of developmental disorders affecting primarily the anterior segment of the…”
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The kinetic Direct Peptide Reactivity Assay (kDPRA): Intra- and inter-laboratory reproducibility in a seven-laboratory ring trial by Wareing, Britta, Kolle, Susanne N, Birk, Barbara, Alepee, Nathalie, Haupt, Tina, Kathawala, Rishil, Kern, Petra S, Nardelli, Laurent, Raabe, Hans, Rucki, Marian, Ryan, Cindy A, Verkaart, Sjoerd, Westerink, Walter M.A, Landsiedel, Robert, Natsch, Andreas

“…While the skin sensitization hazard of substances can be identified using non-animal methods, the classification of potency into UN GHS sub-categories 1A and…”
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Development and validation of a high-content screening in vitro micronucleus assay in CHO-k1 and HepG2 cells by Westerink, Walter M.A., Schirris, Tom J.J., Horbach, G. Jean, Schoonen, Willem G.E.J.

“…► In drug development assays for the early detection of genotoxicity are needed. ► Two high content screening (HCS) micronucleus assays were developed and…”
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The development of RAD51C, Cystatin A, p53 and Nrf2 luciferase-reporter assays in metabolically competent HepG2 cells for the assessment of mechanism-based genotoxicity and of oxidative stress in the early research phase of drug development by Westerink, Walter M.A., Stevenson, Joe C.R., Horbach, G. Jean, Schoonen, Willem G.E.J.

“…Four different mechanism-based high-throughput luciferase-reporter assays were developed in human HepG2 cells, which contain phase I and II metabolic activity…”
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Evaluation of the Vitotox™ and RadarScreen assays for the rapid assessment of genotoxicity in the early research phase of drug development by Westerink, Walter M.A., Stevenson, Joe C.R., Lauwers, Annick, Griffioen, Gerard, Horbach, G. Jean, Schoonen, Willem G.E.J.

“…The Vitotox™ and RadarScreen assays were evaluated as early screens for mutagenicity and clastogenicity, respectively. The Vitotox™ assay is a bacterial…”
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Preparation and stability tests for polyacrylamide-coated capillaries for capillary electrophoresis by Engelhardt, H., Cuñat-Walter, M.A.

“…The stability of polyacrylamide coatings at high pH values has been tested. It could be shown that overall stability is not limited by the coating of the…”
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Cytotoxic effects of 110 reference compounds on HepG2 cells and for 60 compounds on HeLa, ECC-1 and CHO cells by Schoonen, Willem G.E.J., de Roos, Jeroen A.D.M., Westerink, Walter M.A., Débiton, Eric

“…In this study the focus is on the comparison of fluorometric assays, using Alamar Blue (AB) and Hoechst 33342 coloration, and luminometric assays, using…”
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Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells by Westerink, Walter M.A., Schoonen, Willem G.E.J.

“…Early in vitro toxicity screening might improve the success rate of new chemical entities in pharmaceutical development. In previous studies, the advantage of…”
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The detrimental effect of anti-thyroid drugs on the outcome of radioiodine therapy is not directly due to decreased radioiodine uptake by Walter, M.A, Christ-Crain, M, Müller, B, Müller-Brand, J

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Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells by Westerink, Walter M.A., Schoonen, Willem G.E.J.

“…The HepG2 cell line is a valuable tool for screening for cytotoxicity in the early phase of pharmaceutical development. Some compounds which produce reactive…”
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Planning and reporting of quality-of-life outcomes in cancer trials by Schandelmaier, S., Conen, K., von Elm, E., You, J.J., Blümle, A., Tomonaga, Y., Amstutz, A., Briel, M., Kasenda, B., Schandelmaier, S., Conen, K., von Elm, E., You, J.J., Blümle, A., Tomonaga, Y., Saccilotto, R., Amstutz, A., Bengough, T., Meerpohl, J.J., Stegert, M., Olu, K.K., Tikkinen, K.A.O., Neumann, I., Carrasco-Labra, A., Faulhaber, M., Mulla, S.M., Mertz, D., Akl, E.A., Sun, X., Bassler, D., Busse, J.W., Ferreira-González, I., Lamontagne, F., Nordmann, A., Gloy, V., Raatz, H., Moja, L., Rosenthal, R., Ebrahim, S., Vandvik, P.O., Johnston, B.C., Walter, M.A., Burnand, B., Schwenkglenks, M., Hemkens, L.G., Bucher, H.C., Guyatt, G.H., Briel, M., Kasenda, B.

“…Information about the impact of cancer treatments on patients' quality of life (QoL) is of paramount importance to patients and treating oncologists. Cancer…”
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Variations in radioiodine ablation: decision-making after total thyroidectomy by Maas, O., Forrer, F., Maas, M., Panje, C. M., Blautzik, J., Brühlmeier, M., Engel-Bicik, I., Giovanella, L., Haldemann, A., Kamel, M. E., Kneifel, S., Rottenburger, C., Schaefer, N., Walter, M. A., Weidner, S., Putora, P. M.

“…Background The role of radioiodine treatment following total thyroidectomy for differentiated thyroid cancer is changing. The last major revision of the…”
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REACH alternative testing strategy for skin sensitization in practice: Fact or fiction? by Barentsen, Helma M., Jonis, Simon U., Pelgrom, Sylvia M.G.J., Rijk, Jeroen C.W., Westerink, Walter M.A., Paulussen, Jeannette J.C.

“…From October 2016 the REACH Regulation requires an alternative testing strategy for skin sensitization. The current paper describes our experience when putting…”
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Safety evaluation of rebaudioside A produced by fermentation by Rumelhard, Mélina, Hosako, Hiromi, Eurlings, Irene M.J., Westerink, Walter M.A., Staska, Lauren M., van de Wiel, Jeanine A.G., La Marta, James

“…The safety of rebaudioside A, produced fermentatively by Yarrowia lipolytica encoding the Stevia rebaudiana metabolic pathway (fermentative Reb A), is based on…”
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Correction to: Planning and reporting of quality-of-life outcomes in cancer trials by Schandelmaier, S., Conen, K., von Elm, E., You, J.J., Blümle, A., Tomonaga, Y., Saccilotto, R., Amstutz, A., Bengough, T., Meerpohl, J.J., Stegert, M., Olu, K.K., Tikkinen, K.A.O., Neumann, I., Carrasco-Labra, A., Faulhaber, M., Mulla, S.M., Mertz, D., Akl, E.A., Sun, X., Bassler, D., Busse, J.W., Ferreira-González, I., Lamontagne, F., Nordmann, A., Gloy, V., Raatz, H., Moja, L., Rosenthal, R., Ebrahim, S., Vandvik, P.O., Johnston, B.C., Walter, M.A., Burnand, B., Schwenkglenks, M., Hemkens, L.G., Bucher, H.C., Guyatt, G.H., Briel, M., Kasenda, B.

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Cytotoxic effects of 109 reference compounds on rat H4IIE and human HepG2 hepatocytes. III: Mechanistic assays on oxygen consumption with MitoXpress and NAD(P)H production with Alamar Blue by Schoonen, Willem G.E.J., Stevenson, Joe C.R., Westerink, Walter M.A., Horbach, G. Jean

“…► MitoXpress oxygen consumption assays have additive value for cytotoxicity. ► One hundred and nine drugs had similar toxic effects in rat H4IIE and human…”
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Cytotoxic effects of 110 reference compounds on HepG2 cells and for 60 compounds on HeLa, ECC-1 and CHO cells. II mechanistic assays on NAD(P)H, ATP and DNA contents by Schoonen, Willem G E J, de Roos, Jeroen A D M, Westerink, Walter M A, Débiton, Eric

“…In this study the focus is on the comparison of fluorometric assays, using Alamar Blue (AB) and Hoechst 33342 coloration, and luminometric assays, using…”
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Robust Array-Based Coregulator Binding Assay Predicting ERα-Agonist Potency and Generating Binding Profiles Reflecting Ligand Structure by Aarts, Jac M. M. J. G, Wang, Si, Houtman, René, van Beuningen, Rinie M. G. J, Westerink, Walter M. A, Van De Waart, Beppy J, Rietjens, Ivonne M. C. M, Bovee, Toine F. H

“…Testing chemicals for their endocrine-disrupting potential, including interference with estrogen receptor (ER) signaling, is an important aspect of chemical…”
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Cytotoxic effects of 100 reference compounds on Hep G2 and HeLa cells and of 60 compounds on ECC-1 and CHO cells. I Mechanistic assays on ROS, glutathione depletion and calcein uptake by Schoonen, Willem G.E.J., Westerink, Walter M.A., de Roos, Jeroen A.D.M., Débiton, Eric

“…In this study fluorometric assays have been used for medium throughput screening on toxicity. Dichlorofluorescein diacetate, monochlorobimane and calcein-AM…”
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CYP1A induction and species differences between human HepG2 and rat H4IIE cells by Westerink, Walter M.A., Stevenson, Joe C.R., Schoonen, Willem G.E.J.

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