Search Results - "Walter, Alexandra"

Synthetic C6‐Functionalized Aminoflavin Catalysts Enable Aerobic Bromination of Oxidation‐Prone Substrates by Walter, Alexandra, Storch, Golo

“…Flavoenzymes catalyze oxidations via hydroperoxide intermediates that result from activation of molecular O2. These reactions—such as hydroxylation and…”
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Discovery of Inhibitors of Schistosoma mansoni HDAC8 by Combining Homology Modeling, Virtual Screening, and in Vitro Validation by Kannan, Srinivasaraghavan, Melesina, Jelena, Hauser, Alexander-Thomas, Chakrabarti, Alokta, Heimburg, Tino, Schmidtkunz, Karin, Walter, Alexandra, Marek, Martin, Pierce, Raymond J, Romier, Christophe, Jung, Manfred, Sippl, Wolfgang

“…Schistosomiasis, caused by S. mansoni, is a tropical disease that affects over 200 million people worldwide. A novel approach for targeting eukaryotic…”
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Single-case design evaluation of compression therapy for edema of the stroke-affected hand by Gustafsson, Louise, Walter, Alexandra, Bower, Kylie, Slaughter, Adrienne, Hoyle, Melanie

“…OBJECTIVE. To explore the efficacy of low- and high-stretch compression bandaging for edema management in the stroke-affected upper limb. METHOD. A…”
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Photochemical Desaturation and Epoxidation with Oxygen by Sequential Flavin Catalysis by Walter, Alexandra, Eisenreich, Wolfgang, Storch, Golo

“…Abstract Catalytic desaturations are important strategies for the functionalization of organic molecules. In nature, flavoenzymes mediate the formation of…”
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Molecular flavin catalysts for C-H functionalisation and derivatisation of dehydroamino acids by Rehpenn, Andreas, Walter, Alexandra, Storch, Golo

“…In nature, the isoalloxazine heterocycle of flavin cofactors undergoes reversible covalent bond formation with a variety of different reaction partners. These…”
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Dupilumab for treatment of atopic dermatitis by Seegräber, Marlene, Srour, Jerome, Walter, Alexandra, Knop, Macarena, Wollenberg, Andreas

“…Dupilumab is a new treatment option for patients with moderate-to-severe atopic dermatitis. It blocks IL-4/IL13-signaling and thereby inhibits receptor…”
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Food-Related Contact Dermatitis, Contact Urticaria, and Atopy Patch Test with Food by Walter, Alexandra, Seegräber, Marlene, Wollenberg, Andreas

“…A wide variety of foods may cause or aggravate skin diseases such as contact dermatitis, contact urticaria, or atopic dermatitis (AD), both in occupational and…”
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Synthetische, C6‐funktionalisierte Aminoflavinkatalysatoren ermöglichen die aerobe Bromierung oxidationsanfälliger Substrate by Walter, Alexandra, Storch, Golo

“…Flavoenzyme katalysieren Oxidationsreaktionen mithilfe von Hydroperoxid‐Intermediaten, die durch Aktivierung von molekularem O2 gebildet werden. Diese…”
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Reduced Molecular Flavins as Single-Electron Reductants after Photoexcitation by Foja, Richard, Walter, Alexandra, Jandl, Christian, Thyrhaug, Erling, Hauer, Jürgen, Storch, Golo

“…Flavoenzymes mediate a multitude of chemical reactions and are catalytically active both in different oxidation states and in covalent adducts with reagents…”
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Photochemical Desaturation and Epoxidation with Oxygen by Sequential Flavin Catalysis by Walter, Alexandra, Eisenreich, Wolfgang, Storch, Golo

“…Abstract Catalytic desaturations are important strategies for the functionalization of organic molecules. In nature, flavoenzymes mediate the formation of…”
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Essential parameters needed for a U-Net-based segmentation of individual bones on planning CT images in the head and neck region using limited datasets for radiotherapy application by Yawson, Ama Katseena, Walter, Alexandra, Wolf, Nora, Klüter, Sebastian, Hoegen, Philip, Adeberg, Sebastian, Debus, Jürgen, Frank, Martin, Jäkel, Oliver, Giske, Kristina

“…The field of radiotherapy is highly marked by the lack of datasets even with the availability of public datasets. Our study uses a very limited dataset to…”
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Biofidelic image registration for head and neck region utilizing an in-silico articulated skeleton as a transformation model by Bauer, Cornelius J, Teske, Hendrik, Walter, Alexandra, Hoegen, Philipp, Adeberg, Sebastian, Debus, Jürgen, Jäkel, Oliver, Giske, Kristina

“…We propose an integration scheme for a biomechanical motion model into a deformable image registration. We demonstrate its accuracy and reproducibility for…”
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Mathematical model of the MenD-catalyzed 1,4-addition (Stetter reaction) of α-ketoglutaric acid to acrylonitrile by Sudar, Martina, Vasić-Rački, Đurđa, Müller, Michael, Walter, Alexandra, Blažević, Zvjezdana Findrik

“…•Untypical substrate, acrylonitrile, used in enzymatic reaction.•Kinetic model of MenD-catalyzed 1,4-addition of α-ketoglutaric acid to acrylonitrile.•Yield of…”
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Molecular Basis for the Antiparasitic Activity of a Mercaptoacetamide Derivative That Inhibits Histone Deacetylase 8 (HDAC8) from the Human Pathogen Schistosoma mansoni by Stolfa, Diana A., Marek, Martin, Lancelot, Julien, Hauser, Alexander-Thomas, Walter, Alexandra, Leproult, Emeline, Melesina, Jelena, Rumpf, Tobias, Wurtz, Jean-Marie, Cavarelli, Jean, Sippl, Wolfgang, Pierce, Raymond J., Romier, Christophe, Jung, Manfred

“…Schistosomiasis, caused by the parasitic flatworm Schistosoma mansoni and related species, is a tropical disease that affects over 200 million people…”
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Segmentation of 71 Anatomical Structures Necessary for the Evaluation of Guideline-Conforming Clinical Target Volumes in Head and Neck Cancers by Walter, Alexandra, Hoegen-Saßmannshausen, Philipp, Stanic, Goran, Rodrigues, Joao Pedro, Adeberg, Sebastian, Jäkel, Oliver, Frank, Martin, Giske, Kristina

“…The delineation of the clinical target volumes (CTVs) for radiation therapy is time-consuming, requires intensive training and shows high inter-observer…”
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LSD1 Inhibition Induces Differentiation and Reduces the Frequency of Leukemia-Initiating Cells in Hoxa9/Meis1-Induced Acute Myeloid Leukemia by Barth, Jessica, Scheder, Anna-Maria, Mohr, Sebastian, Johannes, Schulz-Fincke, Schmitt, Martin, Walter, Alexandra, Tosic, Milica, Metzger, Eric, Lübbert, Michael, Jung, Manfred, Serve, Hubert, Schüle, Roland, Berg, Tobias

“…The histone demethylating enzyme LSD1 has emerged as a promising epigenetic target in the treatment of acute myeloid leukemia (AML). Inhibition of LSD1 has…”
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LSD1 Inhibition Leads to Differentiation in Hoxa9/Meis1- but Not in MN1-Induced Acute Myeloid Leukemia by Barth, Jessica, Scheder, Anna-Maria, Mohr, Sebastian, Schulz-Fincke, Johannes, Schmitt, Martin, Walter, Alexandra, Tosic, Milica, Metzger, Eric, Bug, Gesine, Lübbert, Michael, Jung, Manfred, Serve, Hubert, Schüle, Roland, Berg, Tobias

“…Lysine specific demethylase 1 (LSD1) represents a promising epigenetic target in the treatment of acute myeloid leukemia (AML) and inhibition of LSD1 has been…”
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Lsd1 inhibition induces differentiation and decreases leukemic stem cell frequency in Hoxa9/Meis1-driven AML by Barth, Jessica, Scheder, Anna-Maria, Mohr, Sebastian, Schulz-Fincke, Johannes, Schmitt, Martin, Walter, Alexandra, Tosic, Milica, Metzger, Eric, Lübbert, Michael, Jung, Manfred, Serve, Hubert, Schüle, Roland, Berg, Tobias

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Topical Therapy of AD: How to Reach Better Results by Walter, Alexandra, Seegräber, Marlene, Rothenberger, Christoph, Srour, Jerome, Wollenberg, Andreas

“…Purpose of Review This review summarizes the current state-of-the-art in topical therapy of atopic dermatitis (atopic eczema), a clinically defined, highly…”
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Association between NAD(P)H: Quinone oxidoreductase 1 (NQ01) inactivating C609T polymorphism and adenocarcinoma of the upper gastrointestinal tract by Sarbia, Mario, Bitzer, Monika, Siegel, David, Ross, David, Schulz, Wolfgang A., Zotz, Rainer B., Kiel, Sybille, Geddert, Helene, Kandemir, Yasemin, Walter, Alexandra, Willers, Reinhart, Gabbert, Helmut E.

“…NQO1 is an antioxidant enzyme, important in the detoxification of environmental carcinogens. A single nucleotide polymorphism (C→T) at position 609 of the NQO1…”
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