Search Results - "Walsh, Kenneth B"

Molecular Pharmacology of Synthetic Cannabinoids: Delineating CB1 Receptor-Mediated Cell Signaling by Walsh, Kenneth B, Andersen, Haley K

“…Synthetic cannabinoids (SCs) are a class of new psychoactive substances (NPSs) that exhibit high affinity binding to the cannabinoid CB1 and CB2 receptors and…”
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Minor Cannabinoids: Biosynthesis, Molecular Pharmacology and Potential Therapeutic Uses by Walsh, Kenneth B, McKinney, Amanda E, Holmes, Andrea E

“…The medicinal use of can be traced back thousands of years to ancient China and Egypt. While marijuana has recently shown promise in managing chronic pain and…”
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Comparing CB1 receptor GIRK channel responses to receptor internalization using a kinetic imaging assay by Andersen, Haley K., Vardakas, Duncan G., Lamothe, Julie A., Perault, Tannis E. A., Walsh, Kenneth B., Laprairie, Robert B.

“…The type 1 cannabinoid receptor (CB1R) mediates neurotransmitter release and synaptic plasticity in the central nervous system. Endogenous, plant-derived,…”
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Molecular signaling of synthetic cannabinoids: Comparison of CB1 receptor and TRPV1 channel activation by Andersen, Haley K., Walsh, Kenneth B.

“…Recreational use of synthetic cannabinoids (SCs) is associated with desirable euphoric and relaxation effects as well as adverse effects including anxiety,…”
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Direct measurement of K ion efflux from neuronal cells using a graphene-based ion sensitive field effect transistor by Li, Hongmei, Walsh, Kenneth B, Bayram, Ferhat, Koley, Goutam

“…A graphene-based ion sensitive field effect transistor (GISFET) has been developed and investigated in terms of its ion sensing performance. The GISFET sensor…”
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Targeting cardiac potassium channels for state-of-the-art drug discovery by Walsh, Kenneth B

“…Cardiac K(+) channels play a critical role in maintaining the normal electrical activity of the heart by setting the cell resting membrane potential and by…”
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Application of ion-sensitive field effect transistors for ion channel screening by Walsh, Kenneth B., DeRoller, Nicholas, Zhu, Yihao, Koley, Goutam

“…Cell-based screening assays are now widely used for identifying compounds that serve as ion channel modulators. However, instrumentation for the automated,…”
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Targeting GIRK Channels for the Development of New Therapeutic Agents by Walsh, Kenneth B

“…G protein-coupled inward rectifier K(+) (GIRK) channels represent novel targets for the development of new therapeutic agents. GIRK channels are activated by a…”
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A real time screening assay for cannabinoid CB1 receptor-mediated signaling by Andersen, Haley K., Piroli, Gerardo G., Walsh, Kenneth B.

“…The cannabinoid CB1 receptor is expressed throughout the central nervous system where it functions to regulate neurotransmitter release and synaptic…”
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Neonatal rat cardiac fibroblasts express three types of voltage-gated K+ channels: regulation of a transient outward current by protein kinase C by Walsh, Kenneth B, Zhang, Jining

“…Cardiac fibroblasts regulate myocardial development via mechanical, chemical, and electrical interactions with associated cardiomyocytes. The goal of this…”
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N-(2-methoxyphenyl) benzenesulfonamide, a novel regulator of neuronal G protein-gated inward rectifier K+ channels by Walsh, Kenneth B., Gay, Elaine A., Blough, Bruce E., Geurkink, David W.

“…G protein-gated inward rectifier K+ (GIRK) channels are members of the super-family of proteins known as inward rectifier K+ (Kir) channels and are expressed…”
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A real-time screening assay for GIRK1/4 channel blockers by Walsh, Kenneth B

“…The cardiac acetylcholine-activated K(+) channel (I(K,Ach)) represents a novel target for drug therapy in the treatment of atrial fibrillation (AF). This…”
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Erratum to: Conformational changes and translocation of tissue-transglutaminase to the plasma membranes: role in cancer cell migration by Kumar, Ambrish, Hu, Jianjun, LaVoie, Holly A, Walsh, Kenneth B, DiPette, Donald J, Singh, Ugra S

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Mechanical Stimulation Regulates Voltage-Gated Potassium Currents in Cardiac Microvascular Endothelial Cells by Fan, Jinping, Walsh, Kenneth B

“…Vascular endothelial cells are constantly exposed to mechanical forces resulting from blood flow and transmural pressure. The goal of this study was to…”
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Conformational changes and translocation of tissue-transglutaminase to the plasma membranes: role in cancer cell migration by Kumar, Ambrish, Hu, Jianjun, LaVoie, Holly A, Walsh, Kenneth B, DiPette, Donald J, Singh, Ugra S

“…Tissue-transglutaminase (TG2), a dual function G-protein, plays key roles in cell differentiation and migration. In our previous studies we reported the…”
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Regulation of a Heart Potassium Channel by Protein Kinase A and C by Walsh, Kenneth B., Kass, Robert S.

“…The enzymes adenosine 3′,5′-monophosphate (cAMP)-dependent protein kinase (protein kinase A) and protein kinase C regulate the activity of a diverse group of…”
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Structural and ionic determinants of 5‐nitro‐2‐(3‐phenylpropylamino)‐benzoic acid block of the CFTR chloride channel by Walsh, Kenneth B, Long, Kathryn J, Shen, Xufeng

“…The goals of this study were to identify the structural components required for arylaminobenzoate block of the cystic fibrosis transmembrane conductance…”
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A fluorescent screening assay for identifying modulators of GIRK channels by Vazquez, Maribel, Dunn, Charity A, Walsh, Kenneth B

“…G protein-gated inward rectifier K+ (GIRK) channels function as cellular mediators of a wide range of hormones and neurotransmitters and are expressed in the…”
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Regulation of cardiac volume-sensitive chloride channel by focal adhesion kinase and Src kinase by Walsh, Kenneth B, Zhang, Jining

“…The volume-sensitive chloride current (ICl,swell) is found in the mammalian myocardium and is activated by osmotic swelling. The goal of this study was to…”
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Development of a High-throughput Assay for Monitoring cAMP Levels in Cardiac Ventricular Myocytes by Walsh, Kenneth B, Rich, Thomas C, Coffman, Zachary J

“…G-protein-coupled receptors (GPCRs) represent the largest family of transmembrane receptors involved in cell signal transduction. Many of these GPCRs convey…”
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