Search Results - "Walsh, Joseph C."

The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities by Walsh, Joseph C, Lebedev, Artem, Aten, Edward, Madsen, Kathleen, Marciano, Liane, Kolb, Hartmuth C

“…Tumor hypoxia is a well-established biological phenomenon that affects the curability of solid tumors, regardless of treatment modality. Especially for head…”
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[18 F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease by Xia, Chun-Fang, Arteaga, Janna, Chen, Gang, Gangadharmath, Umesh, Gomez, Luis F, Kasi, Dhanalakshmi, Lam, Chung, Liang, Qianwa, Liu, Changhui, Mocharla, Vani P, Mu, Fanrong, Sinha, Anjana, Su, Helen, Szardenings, A. Katrin, Walsh, Joseph C, Wang, Eric, Yu, Chul, Zhang, Wei, Zhao, Tieming, Kolb, Hartmuth C

“…Abstract Objective We wished to develop a highly selective positron emission tomography (PET) imaging agent targeting PHF-tau in human Alzheimer's disease (AD)…”
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A highly selective and specific PET tracer for imaging of tau pathologies by Zhang, Wei, Arteaga, Janna, Cashion, Daniel K, Chen, Gang, Gangadharmath, Umesh, Gomez, Luis F, Kasi, Dhanalakshmi, Lam, Chung, Liang, Qianwa, Liu, Changhui, Mocharla, Vani P, Mu, Fanrong, Sinha, Anjana, Szardenings, A Katrin, Wang, Eric, Walsh, Joseph C, Xia, Chunfang, Yu, Chul, Zhao, Tieming, Kolb, Hartmuth C

“…Senile plaques and neurofibrillary tangles are prominent neuropathological hallmarks in Alzheimer's disease and are considered to be targets for therapeutic…”
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Preclinical evaluation and validation of [18F]HX4, a promising hypoxia marker for PET imaging by Dubois, Ludwig J, Lieuwes, Natasja G, Janssen, Marco H. M, Peeters, Wenny J. M, Windhorst, Albert D, Walsh, Joseph C, Kolb, Hartmuth C, Öllers, Michel C, Bussink, Johan, van Dongen, Guus A. M. S, van der Kogel, Albert, Lambin, Philippe

“…Hypoxia has been shown to be an important microenvironmental parameter influencing tumor progression and treatment efficacy. Patient guidance for…”
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Applications of click chemistry in radiopharmaceutical development by Walsh, Joseph C, Kolb, Hartmuth C

“…Click chemistry, a concept that employs only practical and reliable transformations for compound synthesis, has made a significant impact in several areas of…”
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Biodistribution and radiation dosimetry of 18F-CP-18, a potential apoptosis imaging agent, as determined from PET/CT scans in healthy volunteers by Doss, Mohan, Kolb, Hartmuth C, Walsh, Joseph C, Mocharla, Vani, Fan, Hong, Chaudhary, Ashok, Zhu, Zhihong, Alpaugh, R Katherine, Lango, Miriam N, Yu, Jian Q

“…(18)F-CP-18, or…”
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Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807 by Chien, David T, Bahri, Shadfar, Szardenings, A Katrin, Walsh, Joseph C, Mu, Fanrong, Su, Min-Ying, Shankle, William R, Elizarov, Arkadij, Kolb, Hartmuth C

“…Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We…”
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Synthesis, radiosynthesis, in vitro and first in vivo evaluation of a new matrix metalloproteinase inhibitor based on γ-fluorinated α-sulfonylaminohydroxamic acid by Hugenberg, Verena, Behrends, Malte, Wagner, Stefan, Hermann, Sven, Schäfers, Michael, Kolb, Hartmuth C., Szardenings, Katrin, Walsh, Joseph C., Gomez, Luis F., Kopka, Klaus, Haufe, Günter

“…Background To study MMP activity in vivo in disease, several radiolabeled MMP inhibitors functioning as radiotracers have been evaluated by means of SPECT and…”
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Early clinical PET imaging results with the novel PHF-tau radioligand [F18]-T808 by Chien, David T, Szardenings, A Katrin, Bahri, Shadfar, Walsh, Joseph C, Mu, Fanrong, Xia, Chunfang, Shankle, William R, Lerner, Alan J, Su, Min-Ying, Elizarov, Arkadij, Kolb, Hartmuth C

“…Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We…”
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Noninvasive molecular imaging of apoptosis in a mouse model of anthracycline-induced cardiotoxicity by Su, Helen, Gorodny, Natalia, Gomez, Luis Felipe, Gangadharmath, Umesh, Mu, Fanrong, Chen, Gang, Walsh, Joseph C, Szardenings, Katrin, Kolb, Hartmuth C, Tamarappoo, Balaji

“…Anthracycline-induced cardiotoxicity and myocardial dysfunction may be associated with apoptosis. Caspase 3 catalyzes a terminal step in apoptosis, and its…”
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Evaluation of [18F]-CP18 as a PET Imaging Tracer for Apoptosis by Su, Helen, Chen, Gang, Gangadharmath, Umesh, Gomez, Luis F., Liang, Qianwa, Mu, Fanrong, Mocharla, Vani P., Szardenings, A Katrin, Walsh, Joseph C., Xia, Chun-Fang, Yu, Chul, Kolb, Hartmuth C.

“…Purpose We identified and validated [ 18 F]-CP18, a DEVD (the caspase 3 substrate recognition motif) containing substrate-based compound as an imaging tracer…”
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Author response by Walsh, Joseph C

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Atherosclerotic plaque uptake of a novel integrin tracer 18F-Flotegatide in a mouse model of atherosclerosis by Su, Helen, Gorodny, Natalia, Gomez, Luis Felipe, Gangadharmath, Umesh B., Mu, Fanrong, Chen, Gang, Walsh, Joseph C., Szardenings, Katrin, Berman, Daniel S., Kolb, Hartmuth C., Tamarappoo, Balaji K.

“…Rupture of unstable atherosclerotic plaque that leads to stroke and myocardial infarction may be induced by macrophage infiltration and neovessel formation. A…”
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Radiolabeled hydroxamate-based matrix metalloproteinase inhibitors: How chemical modifications affect pharmacokinetics and metabolic stability by Hugenberg, Verena, Hermann, Sven, Galla, Fabian, Schäfers, Michael, Wünsch, Bernhard, Kolb, Hartmuth C, Szardenings, Katrin, Lebedev, Artem, Walsh, Joseph C, Mocharla, Vani P, Gangadharmath, Umesh B, Kopka, Klaus, Wagner, Stefan

“…Abstract Introduction Dysregulated MMP expression or activation is associated with several diseases. To study MMP activity in vivo by means of PET a…”
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In Vitro and In Vivo Evaluation of the Caspase-3 Substrate-Based Radiotracer [18F]-CP18 for PET Imaging of Apoptosis in Tumors by Xia, Chun-Fang, Chen, Gang, Gangadharmath, Umesh, Gomez, Luis F., Liang, Qianwa, Mu, Fanrong, Mocharla, Vani P., Su, Helen, Szardenings, A. Katrin, Walsh, Joseph C., Zhao, Tieming, Kolb, Hartmuth C.

“…Purpose A novel caspase-3 substrate-based probe [ 18 F]-CP18 was evaluated as an in vivo positron emission tomography (PET) imaging agent for monitoring…”
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Biodistribution and Radiation Dosimetry of the Carbonic Anhydrase IX Imaging Agent [18 F]VM4-037 Determined from PET/CT Scans in Healthy Volunteers by Doss, Mohan, Kolb, Hartmuth C., Walsh, Joseph C., Mocharla, Vani P., Zhu, Zhihong, Haka, Michael, Alpaugh, R. Katherine, Chen, David Y. T., Yu, Jian Q.

“…Purpose [ 18  F]VM4-037 has been developed as a positron emission tomography (PET) imaging marker to detect carbonic anhydrase IX (CA-IX) overexpression and is…”
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From In Situ to In Vivo: An In Situ Click-Chemistry-Derived Carbonic Anhydrase II Imaging Agent for Positron Emission Tomography by Mocharla, Vani P., Walsh, Joseph C., Padgett, Henry C., Su, Helen, Fueger, Barbara, Weber, Wolfgang A., Czernin, Johannes, Kolb, Hartmuth C.

“…CA II makes a good PET: Discovering positron emission tomography (PET) probes with high target affinities is challenging. PET probe discovery using in situ…”
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From InSitu to In Vivo: An InSitu Click-Chemistry-Derived Carbonic AnhydraseII Imaging Agent for Positron Emission Tomography by Mocharla, Vani P, Walsh, Joseph C, Padgett, Henry C, Su, Helen, Fueger, Barbara, Weber, Wolfgang A, Czernin, Johannes, Kolb, Hartmuth C

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18F-HX4 hypoxia imaging with PET/CT in head and neck cancer: a comparison with 18F-FMISO by Chen, Limin, Zhang, Zhengwei, Kolb, Hartmuth C, Walsh, Joseph C, Zhang, James, Guan, Yihui

“…OBJECTIVEHypoxia is an important negative prognostic factor for radiation treatment of head and neck (H&N) cancer. The focus of this study was to evaluate the…”
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Biodistribution and radiation dosimetry of the integrin marker 18F-RGD-K5 determined from whole-body PET/CT in monkeys and humans by Doss, Mohan, Kolb, Hartmuth C, Zhang, James J, Bélanger, Marie-José, Stubbs, James B, Stabin, Michael G, Hostetler, Eric D, Alpaugh, R Katherine, von Mehren, Margaret, Walsh, Joseph C, Haka, Michael, Mocharla, Vani P, Yu, Jian Q

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