Search Results - "Walsh, Jessica J."

Gating of social reward by oxytocin in the ventral tegmental area by Hung, Lin W., Neuner, Sophie, Polepalli, Jai S., Beier, Kevin T., Wright, Matthew, Walsh, Jessica J., Lewis, Eastman M., Luo, Liqun, Deisseroth, Karl, Dölen, Gül, Malenka, Robert C.

“…The reward generated by social interactions is critical for promoting prosocial behaviors. Here we present evidence that oxytocin (OXT) release in the ventral…”
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Essential Role of Mesolimbic Brain-Derived Neurotrophic Factor in Chronic Social Stress–Induced Depressive Behaviors by Wook Koo, Ja, Labonté, Benoit, Engmann, Olivia, Calipari, Erin S, Juarez, Barbara, Lorsch, Zachary, Walsh, Jessica J, Friedman, Allyson K, Yorgason, Jordan T, Han, Ming-Hu, Nestler, Eric J

“…Abstract Background Previous work has shown that chronic social defeat stress (CSDS) induces increased phasic firing of ventral tegmental area (VTA) dopamine…”
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Enhancing Depression Mechanisms in Midbrain Dopamine Neurons Achieves Homeostatic Resilience by Friedman, Allyson K., Walsh, Jessica J., Juarez, Barbara, Ku, Stacy M., Chaudhury, Dipesh, Wang, Jing, Li, Xianting, Dietz, David M., Pan, Nina, Vialou, Vincent F., Neve, Rachael L., Yue, Zhenyu, Han, Ming-Hu

“…Typical therapies try to reverse pathogenic mechanisms. Here, we describe treatment effects achieved by enhancing depression-causing mechanisms in ventral…”
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Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors by Morel, Carole, Montgomery, Sarah E., Li, Long, Durand-de Cuttoli, Romain, Teichman, Emily M., Juarez, Barbara, Tzavaras, Nikos, Ku, Stacy M., Flanigan, Meghan E., Cai, Min, Walsh, Jessica J., Russo, Scott J., Nestler, Eric J., Calipari, Erin S., Friedman, Allyson K., Han, Ming-Hu

“…Anxiety disorders are complex diseases, and often co-occur with depression. It is as yet unclear if a common neural circuit controls anxiety-related behaviors…”
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Selective filtering of excitatory inputs to nucleus accumbens by dopamine and serotonin by Christoffel, Daniel J., Walsh, Jessica J., Hoerbelt, Paul, Heifets, Boris D., Llorach, Pierre, Lopez, Ricardo C., Ramakrishnan, Charu, Deisseroth, Karl, Malenka, Robert C.

“…The detailed mechanisms by which dopamine (DA) and serotonin (5-HT) act in the nucleus accumbens (NAc) to influence motivated behaviors in distinct ways remain…”
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Basal forebrain projections to the lateral habenula modulate aggression reward by Golden, Sam A., Heshmati, Mitra, Flanigan, Meghan, Christoffel, Daniel J., Guise, Kevin, Pfau, Madeline L., Aleyasin, Hossein, Menard, Caroline, Zhang, Hongxing, Hodes, Georgia E., Bregman, Dana, Khibnik, Lena, Tai, Jonathan, Rebusi, Nicole, Krawitz, Brian, Chaudhury, Dipesh, Walsh, Jessica J., Han, Ming-Hu, Shapiro, Matt L., Russo, Scott J.

“…Here, the circuits underlying the motivational or rewarding component to aggression are deconstructed, showing that an inhibitory projection from the basal…”
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Dissecting neural mechanisms of prosocial behaviors by Walsh, Jessica J, Christoffel, Daniel J, Wu, Xiaoting, Pomrenze, Matthew B, Malenka, Robert C

“…•Neural circuits mediating prosocial behaviors are being defined using modern methods.•Modulation of mesolimbic reward circuitry plays a key role in promoting…”
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Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding by Christoffel, Daniel J., Walsh, Jessica J., Heifets, Boris D., Hoerbelt, Paul, Neuner, Sophie, Sun, Gordon, Ravikumar, Vinod K., Wu, Hemmings, Halpern, Casey H., Malenka, Robert C.

“…Hedonic feeding is driven by the “pleasure” derived from consuming palatable food and occurs in the absence of metabolic need. It plays a critical role in the…”
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Mesolimbic dopamine neurons in the brain reward circuit mediate susceptibility to social defeat and antidepressant action by Cao, Jun-Li, Covington, 3rd, Herbert E, Friedman, Allyson K, Wilkinson, Matthew B, Walsh, Jessica J, Cooper, Donald C, Nestler, Eric J, Han, Ming-Hu

“…We previously reported that the activity of mesolimbic dopamine neurons of the ventral tegmental area (VTA) is a key determinant of behavioral susceptibility…”
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KCNQ channel openers reverse depressive symptoms via an active resilience mechanism by Friedman, Allyson K., Juarez, Barbara, Ku, Stacy M., Zhang, Hongxing, Calizo, Rhodora C., Walsh, Jessica J., Chaudhury, Dipesh, Zhang, Song, Hawkins, Angel, Dietz, David M., Murrough, James W., Ribadeneira, Maria, Wong, Erik H., Neve, Rachael L., Han, Ming-Hu

“…Less than half of patients suffering from major depressive disorder, a leading cause of disability worldwide, achieve remission with current antidepressants,…”
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Distinct neural mechanisms for the prosocial and rewarding properties of MDMA by Heifets, Boris D, Salgado, Juliana S, Taylor, Madison D, Hoerbelt, Paul, Cardozo Pinto, Daniel F, Steinberg, Elizabeth E, Walsh, Jessica J, Sze, Ji Y, Malenka, Robert C

“…The extensively abused recreational drug (±)3,4-methylenedioxymethamphetamine (MDMA) has shown promise as an adjunct to psychotherapy for treatment-resistant…”
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Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway by Walsh, Jessica J, Friedman, Allyson K, Sun, Haosheng, Heller, Elizabeth A, Ku, Stacy M, Juarez, Barbara, Burnham, Veronica L, Mazei-Robison, Michelle S, Ferguson, Deveroux, Golden, Sam A, Koo, Ja Wook, Chaudhury, Dipesh, Christoffel, Daniel J, Pomeranz, Lisa, Friedman, Jeffrey M, Russo, Scott J, Nestler, Eric J, Han, Ming-Hu

“…Chronic social-defeat stress increases phasic firing of ventral tegmental area (VTA) neurons and increases the amount of BDNF in the nucleus accumbens (NAc)…”
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Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress by Christoffel, Daniel J, Golden, Sam A, Walsh, Jessica J, Guise, Kevin G, Heshmati, Mitra, Friedman, Allyson K, Dey, Aditi, Smith, Milo, Rebusi, Nicole, Pfau, Madeline, Ables, Jessica L, Aleyasin, Hossein, Khibnik, Lena A, Hodes, Georgia E, Ben-Dor, Gabriel A, Deisseroth, Karl, Shapiro, Matthew L, Malenka, Robert C, Ibanez-Tallon, Ines, Han, Ming-Hu, Russo, Scott J

“…Chronic social stress has adverse behavioral consequences and can result in the development of depression in humans. Using a rodent social stress model, we…”
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Author Correction: Midbrain circuit regulation of individual alcohol drinking behaviors in mice by Juarez, Barbara, Morel, Carole, Ku, Stacy M., Liu, Yutong, Zhang, Hongxing, Montgomery, Sarah, Gregoire, Hilledna, Ribeiro, Efrain, Crumiller, Marshall, Roman-Ortiz, Ciorana, Walsh, Jessica J., Jackson, Kelcy, Croote, Denise E., Zhu, Yingbo, Zhang, Song, Vendruscolo, Leandro F., Edwards, Scott, Roberts, Amanda, Hodes, Georgia E., Lu, Yongke, Calipari, Erin S., Chaudhury, Dipesh, Friedman, Allyson K., Han, Ming-Hu

“…The original version of this Article contained an error in the spelling of the author Scott Edwards, which was incorrectly given as Scott Edward. This has now…”
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Neural circuits regulating prosocial behaviors by Walsh, Jessica J, Christoffel, Daniel J, Malenka, Robert C

“…Positive, prosocial interactions are essential for survival, development, and well-being. These intricate and complex behaviors are mediated by an amalgamation…”
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Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine by Choi, Kwang Ho, Edwards, Scott, Graham, Danielle L, Larson, Erin B, Whisler, Kimberly N, Simmons, Diana, Friedman, Allyson K, Walsh, Jessica J, Rahman, Zia, Monteggia, Lisa M, Eisch, Amelia J, Neve, Rachael L, Nestler, Eric J, Han, Ming-Hu, Self, David W

“…Chronic cocaine use produces numerous biological changes in brain, but relatively few are functionally associated with cocaine reinforcement. Here we show that…”
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5-HT release in nucleus accumbens rescues social deficits in mouse autism model by Walsh, Jessica J., Christoffel, Daniel J., Heifets, Boris D., Ben-Dor, Gabriel A., Selimbeyoglu, Aslihan, Hung, Lin W., Deisseroth, Karl, Malenka, Robert C.

“…Dysfunction in prosocial interactions is a core symptom of autism spectrum disorder. However, the neural mechanisms that underlie sociability are poorly…”
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Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons by Chaudhury, Dipesh, Walsh, Jessica J., Friedman, Allyson K., Juarez, Barbara, Ku, Stacy M., Koo, Ja Wook, Ferguson, Deveroux, Tsai, Hsing-Chen, Pomeranz, Lisa, Christoffel, Daniel J., Nectow, Alexander R., Ekstrand, Mats, Domingos, Ana, Mazei-Robison, Michelle S., Mouzon, Ezekiell, Lobo, Mary Kay, Neve, Rachael L., Friedman, Jeffrey M., Russo, Scott J., Deisseroth, Karl, Nestler, Eric J., Han, Ming-Hu

“…Optogenetic induction of phasic, but not tonic, firing in VTA dopamine neurons induces susceptibility to stress in mice undergoing a subthreshold social-defeat…”
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Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors by Heller, Elizabeth A, Cates, Hannah M, Peña, Catherine J, Sun, Haosheng, Shao, Ningyi, Feng, Jian, Golden, Sam A, Herman, James P, Walsh, Jessica J, Mazei-Robison, Michelle, Ferguson, Deveroux, Knight, Scott, Gerber, Mark A, Nievera, Christian, Han, Ming-Hu, Russo, Scott J, Tamminga, Carol S, Neve, Rachael L, Shen, Li, Zhang, H Steve, Zhang, Feng, Nestler, Eric J

“…The authors selectively modify chromatin in a specific gene in vivo to examine the link between chromatin dynamics and drug- and stress-evoked responses. They…”
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Systemic enhancement of serotonin signaling reverses social deficits in multiple mouse models for ASD by Walsh, Jessica J, Llorach, Pierre, Cardozo Pinto, Daniel F, Wenderski, Wendy, Christoffel, Daniel J, Salgado, Juliana S, Heifets, Boris D, Crabtree, Gerald R, Malenka, Robert C

“…Autism spectrum disorder (ASD) is a common set of heterogeneous neurodevelopmental disorders resulting from a variety of genetic and environmental risk…”
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