Search Results - "Walsh, Calum J"

Beneficial modulation of the gut microbiota by Walsh, Calum J., Guinane, Caitriona M., O’Toole, Paul W., Cotter, Paul D.

“…The human gut microbiota comprises approximately 100 trillion microbial cells and has a significant effect on many aspects of human physiology including…”
Get full text

Nisin J, a Novel Natural Nisin Variant, Is Produced by Staphylococcus capitis Sourced from the Human Skin Microbiota by O'Sullivan, Julie N, O'Connor, Paula M, Rea, Mary C, O'Sullivan, Orla, Walsh, Calum J, Healy, Brian, Mathur, Harsh, Field, Des, Hill, Colin, Ross, R Paul

“…The skin microbiota is thought to play a key role in host protection from infection. Nisin J is a novel nisin variant produced by APC 2923, a strain isolated…”
Get full text

In silico identification of bacteriocin gene clusters in the gastrointestinal tract, based on the Human Microbiome Project's reference genome database by Walsh, Calum J, Guinane, Caitriona M, Hill, Colin, Ross, R Paul, O'Toole, Paul W, Cotter, Paul D

“…The human gut microbiota comprises approximately 100 trillion microbial cells which significantly impact many aspects of human physiology - including…”
Get full text

Evaluation of methods for the reduction of contaminating host reads when performing shotgun metagenomic sequencing of the milk microbiome by Yap, Min, Feehily, Conor, Walsh, Calum J., Fenelon, Mark, Murphy, Eileen F., McAuliffe, Fionnuala M., van Sinderen, Douwe, O’Toole, Paul W., O’Sullivan, Orla, Cotter, Paul D.

“…Shotgun metagenomic sequencing is a valuable tool for the taxonomic and functional profiling of microbial communities. However, this approach is challenging in…”
Get full text

First evidence of production of the lantibiotic nisin P by Garcia-Gutierrez, Enriqueta, O’Connor, Paula M., Saalbach, Gerhard, Walsh, Calum J., Hegarty, James W., Guinane, Caitriona M., Mayer, Melinda J., Narbad, Arjan, Cotter, Paul D.

“…Nisin P is a natural nisin variant, the genetic determinants for which were previously identified in the genomes of two Streptococcus species, albeit with no…”
Get full text

Detailed mapping of Bifidobacterium strain transmission from mother to infant via a dual culture-based and metagenomic approach by Feehily, Conor, O’Neill, Ian J., Walsh, Calum J., Moore, Rebecca L., Killeen, Sarah Louise, Geraghty, Aisling A., Lawton, Elaine M., Byrne, David, Sanchez-Gallardo, Rocio, Nori, Sai Ravi Chandra, Nielsen, Ida Busch, Wortmann, Esther, Matthews, Elizabeth, O’Flaherty, Roisin, Rudd, Pauline M., Groeger, David, Shanahan, Fergus, Saldova, Radka, McAuliffe, Fionnuala M., Van Sinderen, Douwe, Cotter, Paul D.

“…A significant proportion of the infant gut microbiome is considered to be acquired from the mother during and after birth. Thus begins a lifelong and dynamic…”
Get full text

Fermented-Food Metagenomics Reveals Substrate-Associated Differences in Taxonomy and Health-Associated and Antibiotic Resistance Determinants by Leech, John, Cabrera-Rubio, Raul, Walsh, Aaron M, Macori, Guerrino, Walsh, Calum J, Barton, Wiley, Finnegan, Laura, Crispie, Fiona, O'Sullivan, Orla, Claesson, Marcus J, Cotter, Paul D

“…Fermented foods have been the focus of ever greater interest as a consequence of purported health benefits. Indeed, it has been suggested that consumption of…”
Get full text

Identification of ADS024, a newly characterized strain of Bacillus velezensis with direct Clostridiodes difficile killing and toxin degradation bio-activities by O’Donnell, Michelle M., Hegarty, James W., Healy, Brian, Schulz, Sarah, Walsh, Calum J., Hill, Colin, Ross, R. Paul, Rea, Mary C., Farquhar, Ronald, Chesnel, Laurent

“…Clostridioides difficile infection (CDI) remains a significant health threat worldwide. C. difficile is an opportunistic, toxigenic pathogen that takes…”
Get full text

Maternal breastfeeding is associated with offspring microbiome diversity; a secondary analysis of the MicrobeMom randomized control trial by Yelverton, Cara A., Killeen, Sarah Louise, Feehily, Conor, Moore, Rebecca L., Callaghan, Shauna L., Geraghty, Aisling A., Byrne, David F., Walsh, Calum J., Lawton, Elaine M., Murphy, Eileen F., Van Sinderen, Douwe, Cotter, Paul D., McAuliffe, Fionnuala M.

“…Background Microbial dysbiosis in infancy can influence long-term health outcomes such as childhood obesity. The aim of this study is to explore relationships…”
Get full text

The probiotic L. casei LC-XCAL™ improves metabolic health in a diet-induced obesity mouse model without altering the microbiome by Walsh, Calum J, Healy, Selena, O'Toole, Paul W, Murphy, Eileen F, Cotter, Paul D

“…Chronic low-grade inflammation associated with obesity may be a target for improvement of metabolic health. Some exopolysaccharide (EPS)-producing bacteria…”
Get full text

Microbial colonization and resistome dynamics in food processing environments of a newly opened pork cutting industry during 1.5 years of activity by Cobo-Díaz, José F., Alvarez-Molina, Adrián, Alexa, Elena A., Walsh, Calum J., Mencía-Ares, Oscar, Puente-Gómez, Paula, Likotrafiti, Eleni, Fernández-Gómez, Paula, Prieto, Bernardo, Crispie, Fiona, Ruiz, Lorena, González-Raurich, Montserrat, López, Mercedes, Prieto, Miguel, Cotter, Paul, Alvarez-Ordóñez, Avelino

“…Abstract Background The microorganisms that inhabit food processing environments (FPE) can strongly influence the associated food quality and safety. In…”
Get full text

Effect of a bacteriocin-producing Streptococcus salivarius on the pathogen Fusobacterium nucleatum in a model of the human distal colon by Lawrence, Garreth W., McCarthy, Niamh, Walsh, Calum J., Kunyoshi, Tais M., Lawton, Elaine M., O'Connor, Paula M., Begley, Máire, Cotter, Paul D., Guinane, Caitriona M.

“…The gut microbiome is a vast reservoir of microbes, some of which produce antimicrobial peptides called bacteriocins that may inhibit specific bacteria…”
Get full text

The two-component system WalKR provides an essential link between cell wall homeostasis and DNA replication in Staphylococcus aureus by Sharkey, Liam K R, Guerillot, Romain, Walsh, Calum J, Turner, Adrianna M, Lee, Jean Y H, Neville, Stephanie L, Klatt, Stephan, Baines, Sarah L, Pidot, Sacha J, Rossello, Fernando J, Seemann, Torsten, McWilliam, Hamish E G, Cho, Ellie, Carter, Glen P, Howden, Benjamin P, McDevitt, Christopher A, Hachani, Abderrahman, Stinear, Timothy P, Monk, Ian R

“…Among the 16 two-component systems in the opportunistic human pathogen , only WalKR is essential. Like the orthologous systems in other Bacillota, WalKR…”
Get full text

Genotypic and Phenotypic Characterization of Fecal Staphylococcus epidermidis Isolates Suggests Plasticity to Adapt to Different Human Body Sites by Garcia-Gutierrez, Enriqueta, Walsh, Calum J, Sayavedra, Lizbeth, Diaz-Calvo, Teresa, Thapa, Dinesh, Ruas-Madiedo, Patricia, Mayer, Melinda J, Cotter, Paul D, Narbad, Arjan

“…is a commensal species that has been increasingly identified as a nosocomial agent. Despite the interest, little is known about the ability of isolates to…”
Get full text

The microbiome of deep-sea fish reveals new microbial species and a sparsity of antibiotic resistance genes by Collins, Fergus W. J., Walsh, Calum J., Gomez-Sala, Beatriz, Guijarro-García, Elena, Stokes, David, Jakobsdóttir, Klara B., Kristjánsson, Kristján, Burns, Finlay, Cotter, Paul D., Rea, Mary C., Hill, Colin, Ross, R. Paul

“…Adaptation to life in the deep-sea can be dramatic, with fish displaying behaviors and appearances unlike those seen in any other aquatic habitat. However, the…”
Get full text

A high-throughput cytotoxicity screening platform reveals agr -independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular persistence by Hachani, Abderrahman, Giulieri, Stefano G, Guérillot, Romain, Walsh, Calum J, Herisse, Marion, Soe, Ye Mon, Baines, Sarah L, Thomas, David R, Cheung, Shane Doris, Hayes, Ashleigh S, Cho, Ellie, Newton, Hayley J, Pidot, Sacha, Massey, Ruth C, Howden, Benjamin P, Stinear, Timothy P

“…infections are associated with high mortality rates. Often considered an extracellular pathogen, can persist and replicate within host cells, evading immune…”
Get full text

Dietary amino acids, macronutrients, vaginal birth, and breastfeeding are associated with the vaginal microbiome in early pregnancy by Corbett, Gillian A, Moore, Rebecca, Feehily, Conor, Killeen, Sarah Louise, O'Brien, Eileen, Van Sinderen, Douwe, Matthews, Elizabeth, O'Flaherty, Roisin, Rudd, Pauline M, Saldova, Radka, Walsh, Calum J, Lawton, Elaine M, MacIntyre, David A, Corcoran, Siobhan, Cotter, Paul D, McAuliffe, Fionnuala M

“…The vaginal microbiome is a key player in the etiology of spontaneous preterm birth. This study aimed to illustrate maternal environmental factors associated…”
Get full text

In Vitro and In Silico Based Approaches to Identify Potential Novel Bacteriocins from the Athlete Gut Microbiome of an Elite Athlete Cohort by Wosinska, Laura, Walsh, Calum J, O'Connor, Paula M, Lawton, Elaine M, Cotter, Paul D, Guinane, Caitriona M, O'Sullivan, Orla

“…Exercise reduces inflammation, fatigue, and aids overall health. Additionally, physical fitness has been associated with desirable changes in the community…”
Get full text

The Lung Microbiome in Young Children with Cystic Fibrosis: A Prospective Cohort Study by Linnane, Barry, Walsh, Aaron M, Walsh, Calum J, Crispie, Fiona, O'Sullivan, Orla, Cotter, Paul D, McDermott, Michael, Renwick, Julie, McNally, Paul

“…The cystic fibrosis (CF) lung harbours a diverse microbiome and reduced diversity in the CF lung has been associated with advancing age, increased inflammation…”
Get full text

Dairy Products and Dairy-Processing Environments as a Reservoir of Antibiotic Resistance and Quorum-Quenching Determinants as Revealed through Functional Metagenomics by Alexa Oniciuc, Elena A, Walsh, Calum J, Coughlan, Laura M, Awad, Amal, Simon, Cezara A, Ruiz, Lorena, Crispie, Fiona, Cotter, Paul D, Alvarez-Ordóñez, Avelino

“…Here, the role of the dairy-processing chain as a reservoir of antimicrobial resistance (AR) determinants and a source of novel biocontrol quorum-sensing…”
Get full text