Search Results - "Walse, Björn"

The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity by Maurer, Mark F., Lewis, Katherine E., Kuijper, Joseph L., Ardourel, Dan, Gudgeon, Chelsea J., Chandrasekaran, Siddarth, Mudri, Sherri L., Kleist, Kayla N., Navas, Chris, Wolfson, Martin F., Rixon, Mark W., Swanson, Ryan, Dillon, Stacey R., Levin, Steven D., Kimbung, Yengo Raymond, Akutsu, Masato, Logan, Derek T., Walse, Björn, Swiderek, Kristine M., Peng, Stanford L.

“…Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective…”
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Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis by Chen, Yihong, Gialeli, Chrysostomi, Shen, Junyan, Dunér, Pontus, Walse, Björn, Duelli, Annette, Caing-Carlsson, Rhawnie, Blom, Anna M., Zibert, John R., Nilsson, Anna Hultgårdh, Alenfall, Jan, Liang, Chun, Nilsson, Jan

“…The osteopontin-derived peptide FOL-005 stimulates hair growth. Using ligand-receptor glyco-capture technology we identified neuropilin-1 (NRP-1), a known…”
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Collagen VI Contains Multiple Host Defense Peptides with Potent In Vivo Activity by Abdillahi, Suado M, Maaß, Tobias, Kasetty, Gopinath, Strömstedt, Adam A, Baumgarten, Maria, Tati, Ramesh, Nordin, Sara L, Walse, Björn, Wagener, Raimund, Schmidtchen, Artur, Mörgelin, Matthias

“…Collagen VI is a ubiquitous extracellular matrix component that forms extensive microfibrillar networks in most connective tissues. In this study, we describe…”
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Publisher Correction: Targeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs by Petruk, Ganna, Puthia, Manoj, Samsudin, Firdaus, Petrlova, Jitka, Olm, Franziska, Mittendorfer, Margareta, Hyllén, Snejana, Edström, Dag, Strömdahl, Ann-Charlotte, Diehl, Carl, Ekström, Simon, Walse, Björn, Kjellström, Sven, Bond, Peter J., Lindstedt, Sandra, Schmidtchen, Artur

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Targeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs by Petruk, Ganna, Puthia, Manoj, Samsudin, Firdaus, Petrlova, Jitka, Olm, Franziska, Mittendorfer, Margareta, Hyllén, Snejana, Edström, Dag, Strömdahl, Ann-Charlotte, Diehl, Carl, Ekström, Simon, Walse, Björn, Kjellström, Sven, Bond, Peter J., Lindstedt, Sandra, Schmidtchen, Artur

“…There is a clinical need for conceptually new treatments that target the excessive activation of inflammatory pathways during systemic infection…”
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The Structures of Human Dihydroorotate Dehydrogenase with and without Inhibitor Reveal Conformational Flexibility in the Inhibitor and Substrate Binding Sites by Walse, Björn, Dufe, Veronica Tamu, Svensson, Bo, Fritzson, Ingela, Dahlberg, Leif, Khairoullina, Alfia, Wellmar, Ulf, Al-Karadaghi, Salam

“…Inhibitors of dihydroorotate dehydrogenase (DHODH) have been suggested for the treatment of rheumatoid arthritis, psoriasis, autoimmune diseases, Plasmodium,…”
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Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology by Ladds, Marcus J. G.W., Popova, Gergana, Pastor-Fernández, Andrés, Kannan, Srinivasaraghavan, van Leeuwen, Ingeborg M.M., Håkansson, Maria, Walse, Björn, Tholander, Fredrik, Bhatia, Ravi, Verma, Chandra S., Lane, David P., Laín, Sonia

“…The tenovins are a frequently studied class of compounds capable of inhibiting sirtuin activity, which is thought to result in increased acetylation and…”
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Molecular Characterization of a Novel Lytic Enzyme LysC from Clostridium intestinale URNW and Its Antibacterial Activity Mediated by Positively Charged N -Terminal Extension by Plotka, Magdalena, Szadkowska, Monika, Håkansson, Maria, Kovačič, Rebeka, Al-Karadaghi, Salam, Walse, Björn, Werbowy, Olesia, Kaczorowska, Anna-Karina, Kaczorowski, Tadeusz

“…Peptidoglycan hydrolytic enzymes are considered to be a promising alternative to conventional antibiotics in combating bacterial infections. To identify novel…”
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Rational Design of Antimicrobial C3a Analogues with Enhanced Effects against Staphylococci Using an Integrated Structure and Function-Based Approach by Pasupuleti, Mukesh, Walse, Björn, Svensson, Bo, Malmsten, Martin, Schmidtchen, Artur

“…The anaphylatoxin C3a and its inactivated derivative C3adesArg, generated during complement activation, exert direct antimicrobial effects, mediated via its…”
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Crystal structures of the Bacillus subtilis prophage lytic cassette proteins XepA and YomS by Freitag-Pohl, Stefanie, Jasilionis, Andrius, Håkansson, Maria, Svensson, L. Anders, Kovačič, Rebeka, Welin, Martin, Watzlawick, Hildegard, Wang, Lei, Altenbuchner, Josef, Płotka, Magdalena, Kaczorowska, Anna Karina, Kaczorowski, Tadeusz, Nordberg Karlsson, Eva, Al-Karadaghi, Salam, Walse, Björn, Aevarsson, Arnthór, Pohl, Ehmke

“…As part of the Virus‐X Consortium that aims to identify and characterize novel proteins and enzymes from bacteriophages and archaeal viruses, the genes of the…”
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The Interaction Properties of Costimulatory Molecules Revisited by Collins, Alison V., Brodie, Douglas W., Gilbert, Robert J.C., Iaboni, Andrea, Manso-Sancho, Raquel, Walse, Björn, Stuart, David I., van der Merwe, P.Anton, Davis, Simon J.

“…B7-1 and B7-2 are generally thought to have comparable structures and affinities for their receptors, CD28 and CTLA-4, each of which is assumed to be bivalent…”
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Inhibition of Human DHODH by 4-Hydroxycoumarins, Fenamic Acids, and N-(Alkylcarbonyl)anthranilic Acids Identified by Structure-Guided Fragment Selection by Fritzson, Ingela, Svensson, Bo, Al-Karadaghi, Salam, Walse, Björn, Wellmar, Ulf, Nilsson, Ulf J., da Graça Thrige, Dorthe, Jönsson, Stig

“…A strategy that combines virtual screening and structure‐guided selection of fragments was used to identify three unexplored classes of human DHODH inhibitor…”
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Cutting edge: Evidence of direct TCR alpha-chain interaction with superantigen by Pumphrey, Nick, Vuidepot, Annelise, Jakobsen, Bent, Forsberg, Göran, Walse, Björn, Lindkvist-Petersson, Karin

“…Superantigens are known to activate a large number of T cells. The SAg is presented by MHC class II on the APC and its classical feature is that it recognizes…”
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Staphylococcal enterotoxin H induces V alpha-specific expansion of T cells by Petersson, Karin, Pettersson, Helen, Skartved, Niels Jörgen, Walse, Björn, Forsberg, Göran

“…Staphylococcal enterotoxin H (SEH) is a bacterial superantigen secreted by Staphylococcus aureus. Superantigens are presented on the MHC class II and activate…”
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Proteolysis of human thrombin generates novel host defense peptides by Papareddy, Praveen, Rydengård, Victoria, Pasupuleti, Mukesh, Walse, Björn, Mörgelin, Matthias, Chalupka, Anna, Malmsten, Martin, Schmidtchen, Artur

“…The coagulation system is characterized by the sequential and highly localized activation of a series of serine proteases, culminating in the conversion of…”
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Identification of conformational epitopes for human IgG on Chemotaxis inhibitory protein of Staphylococcus aureus by Gustafsson, Erika, Haas, Pieter-Jan, Walse, Björn, Hijnen, Marcel, Furebring, Christina, Ohlin, Mats, van Strijp, Jos A G, van Kessel, Kok P M

“…The Chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS) blocks the Complement fragment C5a receptor (C5aR) and formylated peptide receptor (FPR) and…”
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Virtual Screening and Design with Machine Intelligence Applied to Pim‐1 Kinase Inhibitors by Schneider, Petra, Welin, Martin, Svensson, Bo, Walse, Björn, Schneider, Gisbert

“…Ligand‐based virtual screening of large compound collections, combined with fast bioactivity determination, facilitate the discovery of bioactive molecules…”
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Directed evolution of chemotaxis inhibitory protein of Staphylococcus aureus generates biologically functional variants with reduced interaction with human antibodies by Gustafsson, Erika, Rosén, Anna, Barchan, Karin, van Kessel, Kok P.M., Haraldsson, Karin, Lindman, Stina, Forsberg, Cecilia, Ljung, Lill, Bryder, Karin, Walse, Björn, Haas, Pieter-Jan, van Strijp, Jos A.G., Furebring, Christina

“…Chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS) is a protein that binds and blocks the C5a receptor (C5aR) and formylated peptide receptor,…”
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Insight into the dimer dissociation process of the Chromobacterium violaceum (S)-selective amine transaminase by Ruggieri, Federica, Campillo-Brocal, Jonatan C., Chen, Shan, Humble, Maria S., Walse, Björn, Logan, Derek T., Berglund, Per

“…One of the main factors hampering the implementation in industry of transaminase-based processes for the synthesis of enantiopure amines is their often low…”
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Benzimidazole–galactosides bind selectively to the Galectin-8 N-Terminal domain: Structure-based design and optimisation by Hassan, Mujtaba, van Klaveren, Sjors, Håkansson, Maria, Diehl, Carl, Kovačič, Rebeka, Baussière, Floriane, Sundin, Anders P., Dernovšek, Jaka, Walse, Björn, Zetterberg, Fredrik, Leffler, Hakon, Anderluh, Marko, Tomašič, Tihomir, Jakopin, Žiga, Nilsson, Ulf J.

“…We have obtained the X-ray crystal structure of the galectin-8 N-terminal domain (galectin-8N) with a previously reported quinoline–galactoside ligand at a…”
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