Search Results - "Walsby, Elisabeth J"

The topoisomerase II inhibitor voreloxin causes cell cycle arrest and apoptosis in myeloid leukemia cells and acts in synergy with cytarabine by WALSBY, Elisabeth J, COLES, Steven J, KNAPPER, Steven, BURNETT, Alan K

“…Topoisomerase II is essential for the maintenance of DNA integrity and the survival of proliferating cells. Topoisomerase II poisons, including etoposide and…”
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Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers by Lewis, Thomas, Corcoran, David B, Thurston, David E, Giles, Peter J, Ashelford, Kevin, Walsby, Elisabeth J, Fegan, Christopher D, Pepper, Andrea G S, Miraz Rahman, Khondaker, Pepper, Chris

“…Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are incurable hematological malignancies that are pathologically linked with aberrant NF-κB…”
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The HSP90 inhibitor NVP‐AUY922‐AG inhibits the PI3K and IKK signalling pathways and synergizes with cytarabine in acute myeloid leukaemia cells by Walsby, Elisabeth J., Lazenby, Michelle, Pepper, Chris J., Knapper, Steven, Burnett, Alan K.

“…Summary Heat shock protein 90 (HSP90; HSP90AA1) is a molecular chaperone involved in signalling pathways for cell proliferation, survival, and cellular…”
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FUS expression alters the differentiation response to all‐trans retinoic acid in NB4 and NB4R2 cells by Walsby, Elisabeth J., Gilkes, Amanda F., Tonks, Alex, Darley, Richard L., Mills, Kenneth I.

“…Summary The FUS gene is overexpressed in acute myeloid leukaemia (AML) patients and has roles in transcription and mRNA processing. We used ectopic expression…”
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Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit nuclear factor-κB activity and synergize with bortezomib and ibrutinib in hematologic cancers by Lewis, Thomas, Corcoran, David B., Thurston, David E., Giles, Peter J., Ashelford, Kevin, Walsby, Elisabeth J., Fegan, Christopher D., Pepper, Andrea G. S., Rahman, Khondaker Miraz, Pepper, Chris

“…Chronic lymphocytic leukemia (CLL) and multiple myeloma are incurable hematologic malignancies that are pathologically linked with aberrant nuclear…”
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CXCL12 Enhances CLL Cell and T-Cell Migration in a Dynamic Circulating Model of CLL That Can be Abrogated By the CXCR4 Antagonist ONO-7161 by Walsby, Elisabeth J, Brennan, Paul, Pratt, Guy, Hartmann, Tanja Nicole, Yoshizawa, Toshio, Fegan, Christopher, Pepper, Chris

“…We have recently developed a circulating model of CLL that more accurately mimics the transient interactions that take place between lymphocytes and the…”
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Characterization Of a Novel In Vitro Circulation System Designed To Model The Migration Of Primary CLL Cells Across The Vascular Endothelium by Walsby, Elisabeth J, Buggins, Andrea GS, Devereux, Stephen, Brennan, Paul, Fegan, Chris, Pepper, Chris

“…There is growing evidence that lymphocyte trafficking contributes to the clinical course of chronic lymphocytic leukemia (CLL). However, no in vitro models…”
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The HSP 90 inhibitor NVP ‐ AUY 922‐ AG inhibits the PI 3K and IKK signalling pathways and synergizes with cytarabine in acute myeloid leukaemia cells by Walsby, Elisabeth J., Lazenby, Michelle, Pepper, Chris J., Knapper, Steven, Burnett, Alan K.

“…Summary Heat shock protein 90 ( HSP 90; HSP 90 AA 1) is a molecular chaperone involved in signalling pathways for cell proliferation, survival, and cellular…”
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The HSP90 inhibitor NVP-AUY922-AG inhibits the PI3K and IKK signalling pathways and synergizes with cytarabine in acute myeloid Ieukaemia cells by WALSBY, Elisabeth J, LAZENBY, Michelle, PEPPER, Chris J, KNAPPER, Steven, BURNETT, Alan K

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Lymph Node Derived CLL Cells Have a More Activated Phenotype and Better Antigen Presentation Capabilities Compared To Those From The Peripheral Blood by Buggins, Andrea GS, Pasikowska, Marta, Walsby, Elisabeth J, Cuthill, Kirsty M, Longhi, Maria, Hamilton, Emma, Barber, Linda, Fegan, Chris, Pepper, Chris, Devereux, Stephen

“…It is now well established that CLL is a highly proliferative disease with replication restricted to lymphoid tissue microenvironments. There is good evidence…”
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The Cyclin Dependent Kinase 2, 7 and 9 Inhibitor SNS-032 Has Single Agent Activity in Acute Myeloid Leukaemia Cells and Is Highly Synergistic with Cytarabine by Walsby, Elisabeth J, Pepper, Chris, Knapper, Steven, Burnett, Alan K

“…Abstract 1059 Poster Board I-81 Cyclin dependent kinases (CDKs) are a family of serine/threonine kinases that require activation by binding to cyclin partners…”
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Topoisomerase II Inhibitor Voreloxin Causes Cell Cycle Arrest and Apoptosis in Acute Myeloid Leukaemia Cells and Acts in Synergy with Cytarabine by Walsby, Elisabeth J, Coles, Steven, Knapper, Steven, Pepper, Chris, Burnett, Alan K

“…Abstract 4152 Topoisomerase II is essential for the maintenance of DNA integrity and the survival of proliferating cells. This enzyme functions as a homodimer…”
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L-Gossypol Inhibits NF- κB, Down Regulates Mcl-1 and Induces Apoptosis of Primary Acute Myeloid Leukaemia Cells by Pepper, Chris J, Osman, Hani Y, Hewamana, Saman, Walsby, Elisabeth J, Burnett, Alan K, Knapper, Steven

“…Abstract 4813 Standard treatments for acute myeloid leukaemia (AML) result in a median survival of approximately 1 year. There is now a realisation that in…”
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2′–Cyano–2′–Deoxyarabinofuranosylcytosine Is Active in Acute Myeloid Leukaemia and Acts in Synergy with Cytarabine by Walsby, Elisabeth J, Ghiggi, Chiara, Mackay, Ruth H, Green, Simon R, Knapper, Steven, Burnett, Alan K

“…Abstract 4153 2′–Cyano–2′–deoxyarabinofuranosylcytosine (CNDAC) is the metabolic product of sapacitabine following hydrolysis of the palmitoyl sidechain from…”
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The NF-κB Inhibitor LC-1 Has Single Agent Activity in Multiple Myeloma Cells and Synergizes with Bortezomib by Walsby, Elisabeth J., Pratt, Guy, Hewamana, Saman, Crooks, Peter A., Burnett, Alan K., Fegan, Chris, Pepper, Chris

“…Abstract Multiple myeloma remains incurable with conventional therapeutics. Thus, new treatments for this condition are clearly required. In this study we…”
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The Sequence-Selective DNA Cross-Linking Agent SJG-136 (SG2000, BN2629) Is Highly Potent in Multiple Myeloma Cells and Is Synergistic with Bortezimib by Walsby, Elisabeth J, Burnett, Alan, Knapper, Steven, Fegan, Chris, Pepper, Chris

“…Despite recent advances in the treatment of multiple myeloma (MM), including the introduction of bortezimib, it remains an incurable disease with a short…”
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The Parthenolide Derivative LC-1 Is An Effective Single Agent and Is Highly Synergistic with Existing Therapies in Multiple Myeloma by Walsby, Elisabeth J, Hewamana, Saman, Burnett, Alan, Knapper, Steven, Fegan, Chris, Pepper, Chris

“…Multiple myeloma (MM) remains incurable with conventional therapeutic agents and has a median survival of only 3–5 years. Therefore, there is clearly a need…”
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The DNA Crosslinking Agent SJG-136 (SG2000, BN2629) Is Highly Potent in Acute Myeloid Leukaemia and Is Synergistic with Cytarabine by Walsby, Elisabeth J, Burnett, Alan, Knapper, Steven, Fegan, Chris, Pepper, Chris

“…Standard treatment of acute myeloid leukemia (AML) results in a median survival of approximately 1 year. However, increased understanding of the complex…”
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Hsp90 Expression in Acute Myeloid Leukaemia by Walsby, Elisabeth J., Gilkes, Amanda F., Walsh, Valerie, Mills, Kenneth I., Burnett, Alan K.

“…Heat shock protein inhibitors are a potential new class of anti-leukaemic agents with FLT-3 inhibitory activity. 17-allylamino-17-demethoxygeldanamycin…”
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The NF-kappaB inhibitor LC-1 has single agent activity in multiple myeloma cells and synergizes with bortezomib by Walsby, Elisabeth J, Pratt, Guy, Hewamana, Saman, Crooks, Peter A, Burnett, Alan K, Fegan, Chris, Pepper, Chris

“…Multiple myeloma remains incurable with conventional therapeutics. Thus, new treatments for this condition are clearly required. In this study we evaluated the…”
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