Can Cerebral Blood Volume Be Measured Reproducibly With an Improved Near Infrared Spectroscopy System?

Can Cerebral Blood Volume Be Measured Reproducibly With an Improved Near Infrared Spectroscopy System?

In some circumstances, cerebral blood volume (CBV) can be used as a measure for cerebral blood flow. A new near infrared spectroscope was used for determining the reproducibility of CBV measurements assessed by the O2-method. Twenty-seven healthy subjects were investigated. An intrasubject coefficie...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism Vol. 21; no. 2; pp. 110 - 113
Main Authors: Van de Ven, Marjo J. T., Colier, Willy N. J. M., van der Sluijs, Marco C., Walraven, Diederik, Oeseburg, Berend, Folgering, Hans
Format: Journal Article
Language:English
Published: London, England SAGE Publications 01-02-2001
Lippincott Williams & Wilkins
Sage Publications Ltd
Subjects:
Adult
Biological and medical sciences
Blood Volume
Brain
Brain - blood supply
Female
Hemoglobins - analysis
Humans
Investigative techniques of hemodynamics
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Oxyhemoglobins - analysis
Reproducibility of Results
Spectroscopy, Near-Infrared
Near infrared spectroscopy
Brain
Cerebral blood volume
Human studies
Human
Regional blood flow
Near infrared spectrometry
Central nervous system
Exploration
Hemodynamics
Brain (vertebrata)
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Summary:In some circumstances, cerebral blood volume (CBV) can be used as a measure for cerebral blood flow. A new near infrared spectroscope was used for determining the reproducibility of CBV measurements assessed by the O2-method. Twenty-seven healthy subjects were investigated. An intrasubject coefficient of variation (CV) was calculated, based on four identical episodes of desaturation–resaturation (O2-method) procedures for CBV measurements. Two trials were performed, with (trial 1) and without (trial 2) disconnecting the equipment. A mean CV of 12.6% and 10.0% was found in trial 1 and 2, respectively. Cerebral blood volume values yield 3.60 ± 0.82 mL 100 g−1. Cerebral blood volume could be measured reproducible in adults using near infrared spectroscopy, if the arterial desaturation is limited to approximately 5% from baseline level.
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ISSN:0271-678X
1559-7016
DOI:10.1097/00004647-200102000-00002