Search Results - "Walport, Mark J."

The role of complement in the development of systemic lupus erythematosus by Manderson, Anthony P, Botto, Marina, Walport, Mark J

“…Complement has both beneficial and deleterious roles in the pathogenesis of systemic lupus erythematosus (SLE). On the one hand, patients with SLE present with…”
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Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains by Pickering, Matthew C, de Jorge, Elena Goicoechea, Martinez-Barricarte, Rubén, Recalde, Sergio, Garcia-Layana, Alfredo, Rose, Kirsten L, Moss, Jill, Walport, Mark J, Cook, H Terence, de Córdoba, Santiago Rodriguez, Botto, Marina

“…Factor H (FH) is an abundant serum glycoprotein that regulates the alternative pathway of complement-preventing uncontrolled plasma C3 activation and…”
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Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H by Botto, Marina, Pickering, Matthew C, Cook, H. Terence, Warren, Joanna, Bygrave, Anne E, Moss, Jill, Walport, Mark J

“…The alternative pathway of complement is activated continuously in vivo through the C3 'tick-over' pathway. This pathway is triggered by the hydrolysis of C3,…”
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Role of Surfactant Proteins A, D, and C1q in the Clearance of Apoptotic Cells In Vivo and In Vitro: Calreticulin and CD91 as a Common Collectin Receptor Complex by Vandivier, R. William, Ogden, Carol Anne, Fadok, Valerie A, Hoffmann, Peter R, Brown, Kevin K, Botto, Marina, Walport, Mark J, Fisher, James H, Henson, Peter M, Greene, Kelly E

“…Removal of cells dying by apoptosis is essential to normal development, maintenance of tissue homeostasis, and resolution of inflammation. Surfactant protein A…”
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Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice by Rose, Kirsten L, Paixao-Cavalcante, Danielle, Fish, Jennifer, Manderson, Anthony P, Malik, Talat H, Bygrave, Anne E, Lin, Tao, Sacks, Steven H, Walport, Mark J, Cook, H Terence, Botto, Marina, Pickering, Matthew C

“…The inflammatory kidney disease membranoproliferative glomerulonephritis type II (MPGN2) is associated with dysregulation of the alternative pathway of…”
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Predominant role of IgM‐dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow‐derived macrophages in vitro by Quartier, Pierre, Potter, Paul K., Ehrenstein, Michael R., Walport, Mark J., Botto, Marina

“…Soluble molecules including complement components have been shown to facilitate the clearance of dying cells by phagocytes, a process that is important in…”
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The Classical Pathway Is the Dominant Complement Pathway Required for Innate Immunity to Streptococcus pneumoniae Infection in Mice by Brown, Jeremy S., Hussell, Tracy, Gilliland, Sarah M., Holden, David W., Paton, James C., Ehrenstein, Michael R., Walport, Mark J., Botto, Marina

“…The complement system is an important component of the innate immune response to bacterial pathogens, including Streptococcus pneumoniae. The classical…”
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Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice by Bygrave, Anne E, Rose, Kirsten L, Cortes-Hernandez, Josefina, Warren, Joanna, Rigby, Robert J, Cook, H Terence, Walport, Mark J, Vyse, Timothy J, Botto, Marina

“…Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder in which complex genetic factors play an important role. Several strains of…”
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Lupus-Prone Mice Have an Abnormal Response to Thioglycolate and an Impaired Clearance of Apoptotic Cells by Potter, Paul K, Cortes-Hernandez, Josefina, Quartier, Pierre, Botto, Marina, Walport, Mark J

“…Deficiency of complement in humans and mice is associated with the development of lupus and with abnormal repair of inflammatory and immune complex-mediated…”
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C1q Deficiency and Autoimmunity: The Effects of Genetic Background on Disease Expression by Mitchell, Daniel A, Pickering, Matthew C, Warren, Joanna, Fossati-Jimack, Liliane, Cortes-Hernandez, Josefina, Cook, H. Terence, Botto, Marina, Walport, Mark J

“…Gene-targeted C1q-deficient mice have been shown to develop a syndrome reminiscent of human systemic lupus erythematosus with antinuclear Abs and proliferative…”
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Genetic Dissection of Spontaneous Autoimmunity Driven by 129-Derived Chromosome 1 Loci When Expressed on C57BL/6 Mice by Carlucci, Francesco, Cortes-Hernandez, Josefina, Fossati-Jimack, Liliane, Bygrave, Anne E, Walport, Mark J, Vyse, Timothy J, Cook, H. Terence, Botto, Marina

“…Extensive evidence indicates that genetic predisposition is a central element in susceptibility to systemic lupus erythematosus both in humans and animals. We…”
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Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody by Azeredo da Silveira, Samareh, Kikuchi, Shuichi, Fossati-Jimack, Liliane, Moll, Thomas, Saito, Takashi, Verbeek, J Sjef, Botto, Marina, Walport, Mark J, Carroll, Michael, Izui, Shozo

“…By generating four IgG isotype-switch variants of the high affinity 34-3C anti-erythrocyte autoantibody, and comparing them to the IgG variants of the low…”
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Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria by Holt, Dewi S., Botto, Marina, Bygrave, Anne E., Hanna, S. Melanie, Walport, Mark J., Morgan, B. Paul

“…The glycolipid-anchored glycoprotein CD59 inhibits assembly of the lytic membrane attack complex of complement by incorporation into the forming complex…”
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Complement and systemic lupus erythematosus by Walport, Mark J

“…Complement is implicated in the pathogenesis of systemic lupus erythematosus (SLE) in several ways and may act as both friend and foe. Homozygous deficiency of…”
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Restoration of C1q levels by bone marrow transplantation attenuates autoimmune disease associated with C1q deficiency in mice by Cortes‐Hernandez, Josefina, Fossati‐Jimack, Liliane, Petry, Franz, Loos, Michael, Izui, Shozo, Walport, Mark J., Cook, H. Terence, Botto, Marina

“…C1q deficiency in both humans and mice is strongly associated with autoimmunity. We have previously shown that bone marrow transplantation (BMT) restored C1q…”
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Providing incentives to share data early in health emergencies: the role of journal editors by Whitty, Christopher J M, Mundel, Trevor, Farrar, Jeremy, Heymann, David L, Davies, Sally C, Walport, Mark J

“…The early response to the Ebola epidemic, however, was also accompanied by several examples of individuals and organisations being unwilling to share data in…”
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CD59a Deficiency Exacerbates Ischemia-Reperfusion Injury in Mice by Turnberg, Daniel, Botto, Marina, Lewis, Margarita, Zhou, Wuding, Sacks, Steven H., Morgan, B. Paul, Walport, Mark J., Cook, H. Terence

“…The terminal complement components C5a and the membrane attack complex are involved in the pathogenesis of ischemia-reperfusion injury in many organs. CD59 is…”
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Accelerated Nephrotoxic Nephritis Is Exacerbated in C1q-Deficient Mice by Robson, Michael G, Cook, H. Terence, Botto, Marina, Taylor, Philip R, Busso, Nathalie, Salvi, Roberto, Pusey, Charles D, Walport, Mark J, Davies, Kevin A

“…C1q deficiency strongly predisposes to the development of systemic lupus erythematosus in humans and mice. We used the model of accelerated nephrotoxic…”
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CD59a deficiency exacerbates accelerated nephrotoxic nephritis in mice by TURNBERG, Daniel, BOTTO, Marina, WARREN, Joanna, MORGAN, B. Paul, WALPORT, Mark J, COOK, H. Terence

“…CD59 is a complement regulatory protein that inhibits the terminal part of the complement system, the membrane attack complex (MAC), a mediator of renal…”
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Increased Susceptibility of C1q-Deficient Mice to Salmonella enterica Serovar Typhimurium Infection by WARREN, Joanna, MASTROENI, Pietro, DOUGAN, Gordon, NOURSADEGHI, Mahdad, COHEN, Jonathan, WALPORT, Mark J, BOTTO, Marina

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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