Search Results - "Wallscheid, Nina Cabezas"

Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia by Zhang, Yu Wei, Schönberger, Katharina, Cabezas‐Wallscheid, Nina

“…During the last decades, remarkable progress has been made in further understanding the complex molecular regulatory networks that maintain hematopoietic stem…”
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Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1 by Renders, Simon, Svendsen, Arthur Flohr, Panten, Jasper, Rama, Nicolas, Maryanovich, Maria, Sommerkamp, Pia, Ladel, Luisa, Redavid, Anna Rita, Gibert, Benjamin, Lazare, Seka, Ducarouge, Benjamin, Schönberger, Katharina, Narr, Andreas, Tourbez, Manon, Dethmers-Ausema, Bertien, Zwart, Erik, Hotz-Wagenblatt, Agnes, Zhang, Dachuan, Korn, Claudia, Zeisberger, Petra, Przybylla, Adriana, Sohn, Markus, Mendez-Ferrer, Simon, Heikenwälder, Mathias, Brune, Maik, Klimmeck, Daniel, Bystrykh, Leonid, Frenette, Paul S., Mehlen, Patrick, de Haan, Gerald, Cabezas-Wallscheid, Nina, Trumpp, Andreas

“…Haematopoietic stem cells (HSCs) are characterized by their self-renewal potential associated to dormancy. Here we identify the cell surface receptor…”
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Metabolic Regulation of Hematopoietic Stem Cells by Morganti, Claudia, Cabezas‐Wallscheid, Nina, Ito, Keisuke

“…Cellular metabolism is a key regulator of hematopoietic stem cell (HSC) maintenance. HSCs rely on anaerobic glycolysis for energy production to minimize the…”
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Kidins220 regulates the development of B cells bearing the λ light chain by Schaffer, Anna-Maria, Fiala, Gina Jasmin, Hils, Miriam, Natali, Eriberto, Babrak, Lmar, Herr, Laurenz Alexander, Romero-Mulero, Mari Carmen, Cabezas-Wallscheid, Nina, Rizzi, Marta, Miho, Enkelejda, Schamel, Wolfgang W A, Minguet, Susana

“…The ratio between κ and λ light chain (LC)-expressing B cells varies considerably between species. We recently identified Kinase D-interacting substrate of 220…”
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Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1‐ETO mouse model by Cabezas‐Wallscheid, Nina, Eichwald, Victoria, de Graaf, Jos, Löwer, Martin, Lehr, Hans‐Anton, Kreft, Andreas, Eshkind, Leonid, Hildebrandt, Andreas, Abassi, Yasmin, Heck, Rosario, Dehof, Anna Katharina, Ohngemach, Svetlana, Sprengel, Rolf, Wörtge, Simone, Schmitt, Steffen, Lotz, Johannes, Meyer, Claudius, Kindler, Thomas, Zhang, Dong‐Er, Kaina, Bernd, Castle, John C., Trumpp, Andreas, Sahin, Ugur, Bockamp, Ernesto

“…The t(8;21) chromosomal translocation activates aberrant expression of the AML1‐ETO (AE) fusion protein and is commonly associated with core binding factor…”
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Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy by Cabezas-Wallscheid, Nina, Buettner, Florian, Sommerkamp, Pia, Klimmeck, Daniel, Ladel, Luisa, Thalheimer, Frederic B., Pastor-Flores, Daniel, Roma, Leticia P., Renders, Simon, Zeisberger, Petra, Przybylla, Adriana, Schönberger, Katharina, Scognamiglio, Roberta, Altamura, Sandro, Florian, Carolina M., Fawaz, Malak, Vonficht, Dominik, Tesio, Melania, Collier, Paul, Pavlinic, Dinko, Geiger, Hartmut, Schroeder, Timm, Benes, Vladimir, Dick, Tobias P., Rieger, Michael A., Stegle, Oliver, Trumpp, Andreas

“…Dormant hematopoietic stem cells (dHSCs) are atop the hematopoietic hierarchy. The molecular identity of dHSCs and the mechanisms regulating their maintenance…”
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Simplified murine multipotent progenitor isolation scheme: Establishing a consensus approach for multipotent progenitor identification by Challen, Grant A., Pietras, Eric M., Wallscheid, Nina Cabezas, Signer, Robert A.J.

“…•A simplified scheme for identifying murine multipotent progenitor cells is described.•This scheme was developed with assistance and feedback from the ISEH…”
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VarID2 quantifies gene expression noise dynamics and unveils functional heterogeneity of ageing hematopoietic stem cells by Rosales-Alvarez, Reyna Edith, Rettkowski, Jasmin, Herman, Josip Stefan, Dumbović, Gabrijela, Cabezas-Wallscheid, Nina, Grün, Dominic

“…Variability of gene expression due to stochasticity of transcription or variation of extrinsic signals, termed biological noise, is a potential driving force…”
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Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration by Clapes, Thomas, Polyzou, Aikaterini, Prater, Pia, Sagar, Morales-Hernández, Antonio, Ferrarini, Mariana Galvao, Kehrer, Natalie, Lefkopoulos, Stylianos, Bergo, Veronica, Hummel, Barbara, Obier, Nadine, Maticzka, Daniel, Bridgeman, Anne, Herman, Josip S., Ilik, Ibrahim, Klaeylé, Lhéanna, Rehwinkel, Jan, McKinney-Freeman, Shannon, Backofen, Rolf, Akhtar, Asifa, Cabezas-Wallscheid, Nina, Sawarkar, Ritwick, Rebollo, Rita, Grün, Dominic, Trompouki, Eirini

“…Haematopoietic stem cells (HSCs) are normally quiescent, but have evolved mechanisms to respond to stress. Here, we evaluate haematopoietic regeneration…”
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Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells by Sommerkamp, Pia, Romero-Mulero, Mari Carmen, Narr, Andreas, Ladel, Luisa, Hustin, Lucie, Schönberger, Katharina, Renders, Simon, Altamura, Sandro, Zeisberger, Petra, Jäcklein, Karin, Klimmeck, Daniel, Rodriguez-Fraticelli, Alejo, Camargo, Fernando D., Perié, Leïla, Trumpp, Andreas, Cabezas-Wallscheid, Nina

“…Hematopoietic stem cells (HSCs) and distinct multipotent progenitor (MPP) populations (MPP1-4) contained within the Lin−Sca-1+c-Kit+ (LSK) compartment have…”
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Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo by Spohr, Corinna, Poggio, Teresa, Andrieux, Geoffroy, Schönberger, Katharina, Cabezas-Wallscheid, Nina, Boerries, Melanie, Halbach, Sebastian, Illert, Anna L., Brummer, Tilman

“…Internal tandem duplications (ITD) of the FMS-like tyrosine kinase 3 (FLT3) predict poor prognosis in acute myeloid leukemia (AML) and often co-exist with…”
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Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment by Villa, Matteo, Sanin, David E., Apostolova, Petya, Corrado, Mauro, Kabat, Agnieszka M., Cristinzio, Carmine, Regina, Annamaria, Carrizo, Gustavo E., Rana, Nisha, Stanczak, Michal A., Baixauli, Francesc, Grzes, Katarzyna M., Cupovic, Jovana, Solagna, Francesca, Hackl, Alexandra, Globig, Anna-Maria, Hässler, Fabian, Puleston, Daniel J., Kelly, Beth, Cabezas-Wallscheid, Nina, Hasselblatt, Peter, Bengsch, Bertram, Zeiser, Robert, Sagar, Buescher, Joerg M., Pearce, Edward J., Pearce, Erika L.

“…Immune cells must adapt to different environments during the course of an immune response. Here we study the adaptation of CD8 + T cells to the intestinal…”
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The long non-coding RNA Meg3 is dispensable for hematopoietic stem cells by Sommerkamp, Pia, Renders, Simon, Ladel, Luisa, Hotz-Wagenblatt, Agnes, Schönberger, Katharina, Zeisberger, Petra, Przybylla, Adriana, Sohn, Markus, Zhou, Yunli, Klibanski, Anne, Cabezas-Wallscheid, Nina, Trumpp, Andreas

“…The long non-coding RNA (lncRNA) M aternally E xpressed G ene 3 ( Meg3 ) is encoded within the imprinted Dlk1-Meg3 gene locus and is only maternally expressed…”
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Publisher Correction: Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration by Clapes, Thomas, Polyzou, Aikaterini, Prater, Pia, Sagar, Morales-Hernández, Antonio, Ferrarini, Mariana Galvao, Kehrer, Natalie, Lefkopoulos, Stylianos, Bergo, Veronica, Hummel, Barbara, Obier, Nadine, Maticzka, Daniel, Bridgeman, Anne, Herman, Josip S., Ilik, Ibrahim, Klaeylé, Lhéanna, Rehwinkel, Jan, McKinney-Freeman, Shannon, Backofen, Rolf, Akhtar, Asifa, Cabezas-Wallscheid, Nina, Sawarkar, Ritwick, Rebollo, Rita, Grün, Dominic, Trompouki, Eirini

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Targeted LC-MS/MS-based metabolomics and lipidomics on limited hematopoietic stem cell numbers by Schönberger, Katharina, Mitterer, Michael, Buescher, Joerg M., Cabezas-Wallscheid, Nina

“…Metabolism is important for the regulation of hematopoietic stem cells (HSCs) and drives cellular fate. Due to the scarcity of HSCs, it has been technically…”
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Aging alters the epigenetic asymmetry of HSC division by Florian, M Carolina, Klose, Markus, Sacma, Mehmet, Jablanovic, Jelena, Knudson, Luke, Nattamai, Kalpana J, Marka, Gina, Vollmer, Angelika, Soller, Karin, Sakk, Vadim, Cabezas-Wallscheid, Nina, Zheng, Yi, Mulaw, Medhanie A, Glauche, Ingmar, Geiger, Hartmut

“…Hematopoietic stem cells (HSCs) balance self-renewal and differentiation to maintain homeostasis. With aging, the frequency of polar HSCs decreases. Cell…”
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The long noncoding RNA mimi scaffolds neuronal granules to maintain nervous system maturity by Grzejda, Dominika, Mach, Jana, Schweizer, Johanna Aurelia, Hummel, Barbara, Rezansoff, Andrew Mischa, Eggenhofer, Florian, Panhale, Amol, Lalioti, Maria-Eleni, Cabezas Wallscheid, Nina, Backofen, Rolf, Felsenberg, Johannes, Hilgers, Valérie

“…RNA binding proteins and messenger RNAs (mRNAs) assemble into ribonucleoprotein granules that regulate mRNA trafficking, local translation, and turnover. The…”
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Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B by Carnevalli, Larissa S, Scognamiglio, Roberta, Cabezas-Wallscheid, Nina, Rahmig, Susann, Laurenti, Elisa, Masuda, Kohei, Jöckel, Lars, Kuck, Andrea, Sujer, Stefanie, Polykratis, Apostolos, Erlacher, Miriam, Pasparakis, Manolis, Essers, Marieke A G, Trumpp, Andreas

“…The serine protease granzyme B (GzmB) is stored in the granules of cytotoxic T and NK cells and facilitates immune-mediated destruction of virus-infected…”
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Transcriptome-wide Profiling and Posttranscriptional Analysis of Hematopoietic Stem/Progenitor Cell Differentiation toward Myeloid Commitment by Klimmeck, Daniel, Cabezas-Wallscheid, Nina, Reyes, Alejandro, von Paleske, Lisa, Renders, Simon, Hansson, Jenny, Krijgsveld, Jeroen, Huber, Wolfgang, Trumpp, Andreas

“…Hematopoietic stem cells possess lifelong self-renewal activity and generate multipotent progenitors that differentiate into lineage-committed and subsequently…”
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1023 – REGULATION OF DORMANT HEMATOPOIETIC STEM CELLS by Cabezas-Wallscheid, Nina

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