Search Results - "Walls, Stanley M."

Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy by Walls, Stanley M., Cammarato, Anthony, Chatfield, Dale A., Ocorr, Karen, Harris, Greg L., Bodmer, Rolf

“…Lipotoxic cardiomyopathy (LCM) is characterized by abnormal myocardial accumulation of lipids, including ceramide; however, the contribution of ceramide to the…”
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The nutrient sensor CRTC and Sarcalumenin/thinman represent an alternate pathway in cardiac hypertrophy by Dondi, Cristiana, Vogler, Georg, Gupta, Anjali, Walls, Stanley M., Kervadec, Anaïs, Marchant, James, Romero, Michaela R., Diop, Soda, Goode, Jason, Thomas, John B., Colas, Alex R., Bodmer, Rolf, Montminy, Marc, Ocorr, Karen

“…CREB-regulated transcription co-activator (CRTC) is activated by Calcineurin (CaN) to regulate gluconeogenic genes. CaN also has roles in cardiac hypertrophy…”
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Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome by Theis, Jeanne L, Vogler, Georg, Missinato, Maria A, Li, Xing, Nielsen, Tanja, Zeng, Xin-Xin I, Martinez-Fernandez, Almudena, Walls, Stanley M, Kervadec, Anaïs, Kezos, James N, Birker, Katja, Evans, Jared M, O'Byrne, Megan M, Fogarty, Zachary C, Terzic, André, Grossfeld, Paul, Ocorr, Karen, Nelson, Timothy J, Olson, Timothy M, Colas, Alexandre R, Bodmer, Rolf

“…Congenital heart diseases (CHDs), including hypoplastic left heart syndrome (HLHS), are genetically complex and poorly understood. Here, a multidisciplinary…”
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Identification of sphingolipid metabolites that induce obesity via misregulation of appetite, caloric intake and fat storage in Drosophila by Walls, Jr, Stanley M, Attle, Steve J, Brulte, Gregory B, Walls, Marlena L, Finley, Kim D, Chatfield, Dale A, Herr, Deron R, Harris, Greg L

“…Obesity is defined by excessive lipid accumulation. However, the active mechanistic roles that lipids play in its progression are not understood. Accumulation…”
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Systemic and heart autonomous effects of sphingosine Δ4 desaturase deficiency in lipotoxic cardiac pathophysiology by Walls, Stanley M, Chatfield, Dale A, Ocorr, Karen, Harris, Greg L, Bodmer, Rolf

“…Lipotoxic cardiomyopathy (LCM) is characterized by cardiac steatosis, including the accumulation of fatty acids, triglycerides and ceramides. Model systems…”
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Chronic Voluntary Ethanol Consumption Induces Favorable Ceramide Profiles in Selectively Bred Alcohol-Preferring (P) Rats by Godfrey, Jessica, Jeanguenin, Lisa, Castro, Norma, Olney, Jeffrey J, Dudley, Jason, Pipkin, Joseph, Walls, Stanley M, Wang, Wei, Herr, Deron R, Harris, Greg L, Brasser, Susan M

“…Heavy alcohol consumption has detrimental neurologic effects, inducing widespread neuronal loss in both fetuses and adults. One proposed mechanism of…”
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Survival response to increased ceramide involves metabolic adaptation through novel regulators of glycolysis and lipolysis by Nirala, Niraj K, Rahman, Motiur, Walls, Stanley M, Singh, Alka, Zhu, Lihua Julie, Bamba, Takeshi, Fukusaki, Eiichiro, Srideshikan, Sargur M, Harris, Greg L, Ip, Y Tony, Bodmer, Rolf, Acharya, Usha R

“…The sphingolipid ceramide elicits several stress responses, however, organisms survive despite increased ceramide but how they do so is poorly understood. We…”
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Reduced Cardiac Calcineurin Expression Mimics Long-Term Hypoxia-Induced Heart Defects in Drosophila by Zarndt, Rachel, Walls, Stanley M, Ocorr, Karen, Bodmer, Rolf

“…Hypoxia is often associated with cardiopulmonary diseases, which represent some of the leading causes of mortality worldwide. Long-term hypoxia exposures,…”
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Systemic and heart autonomous effects of sphingosine Δ-4 desaturase deficiency in lipotoxic cardiac pathophysiology by Walls, Stanley M., Chatfield, Dale A., Ocorr, Karen, Harris, Greg L., Bodmer, Rolf

“…Lipotoxic cardiomyopathy (LCM) is characterized by cardiac steatosis including accumulation of fatty acids, triglycerides and ceramides. Inhibition of ceramide…”
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Identification of Sphingolipid Metabolites That Induce Obesity via Misregulation of Appetite, Caloric Intake and Fat Storage in Drosophila: e1003970 by Jr, Stanley MWalls, Attle, Steve J, Brulte, Gregory B, Walls, Marlena L, Finley, Kim D, Chatfield, Dale A, Herr, Deron R, Harris, Greg L

“…Obesity is defined by excessive lipid accumulation. However, the active mechanistic roles that lipids play in its progression are not understood. Accumulation…”
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Survival Response to Increased Ceramide Involves Metabolic Adaptation through Novel Regulators of Glycolysis and Lipolysis: e1003556 by Nirala, Niraj K, Rahman, Motiur, Walls, Stanley M, Singh, Alka, Zhu, Lihua Julie, Bamba, Takeshi, Fukusaki, Eiichiro, Srideshikan, Sargur M, Harris, Greg L, Ip, Y Tony, Bodmer, Rolf, Acharya, Usha R

“…The sphingolipid ceramide elicits several stress responses, however, organisms survive despite increased ceramide but how they do so is poorly understood. We…”
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