Search Results - "Walls, Chad D."

Molecular Basis of Gain-of-Function LEOPARD Syndrome-Associated SHP2 Mutations by Yu, Zhi-Hong, Zhang, Ruo-Yu, Walls, Chad D, Chen, Lan, Zhang, Sheng, Wu, Li, Liu, Sijiu, Zhang, Zhong-Yin

“…The Src homology 2 (SH2) domain-containing protein tyrosine phosphatase 2 (SHP2) is a critical signal transducer downstream of growth factors that promotes the…”
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Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2 by Zhang, Ruo-Yu, Yu, Zhi-Hong, Chen, Lan, Walls, Chad D., Zhang, Sheng, Wu, Li, Zhang, Zhong-Yin

“…The protein-tyrosine phosphatase SHP2 is an allosteric enzyme critical for cellular events downstream of growth factor receptors. Mutations in the SHP2 gene…”
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Integrated analysis of global mRNA and protein expression data in HEK293 cells overexpressing PRL-1 by Dumaual, Carmen M, Steere, Boyd A, Walls, Chad D, Wang, Mu, Zhang, Zhong-Yin, Randall, Stephen K

“…The protein tyrosine phosphatase PRL-1 represents a putative oncogene with wide-ranging cellular effects. Overexpression of PRL-1 can promote cell…”
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Cardiovascular Safety During Treatment With Baricitinib in Rheumatoid Arthritis by Taylor, Peter C., Weinblatt, Michael E., Burmester, Gerd R., Rooney, Terence P., Witt, Sarah, Walls, Chad D., Issa, Maher, Salinas, Claudia A., Saifan, Chadi, Zhang, Xin, Cardoso, Anabela, González‐Gay, Miguel A., Takeuchi, Tsutomu

“…Objective To assess the frequency of cardiovascular and venous thromboembolic events in clinical studies of baricitinib, an oral, selective JAK1 and JAK2…”
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Translational Control of C-terminal Src Kinase (Csk) Expression by PRL3 Phosphatase by Liang, Fubo, Luo, Yong, Dong, Yuanshu, Walls, Chad D., Liang, Jiao, Jiang, Hao-Yuan, Sanford, Jeremy R., Wek, Ronald C., Zhang, Zhong-Yin

“…Phosphatase of regenerating liver 3 (PRL3) is up-regulated in cancer metastases. However, little is known of PRL3-mediated cellular signaling pathways. We…”
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Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations by Yu, Zhi-Hong, Xu, Jie, Walls, Chad D., Chen, Lan, Zhang, Sheng, Zhang, Ruoyu, Wu, Li, Wang, Lina, Liu, Sijiu, Zhang, Zhong-Yin

“…SHP2 is an allosteric phosphatase essential for growth factor-mediated Ras activation. Germ-line mutations in SHP2 cause clinically similar LEOPARD and Noonan…”
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Identification of serum N-acetylmuramoyl- l-alanine amidase as liver peptidoglycan recognition protein 2 by Zhang, Yinong, van der Fits, Leslie, Voerman, Jane S., Melief, Marie-Jose, Laman, Jon D., Wang, Mu, Wang, Haitao, Wang, Minhui, Li, Xinna, Walls, Chad D., Gupta, Dipika, Dziarski, Roman

“…N-acetylmuramoyl- l-alanine amidase (NAMLAA) hydrolyzes bacterial peptidoglycan and is present in human serum. A peptidoglycan-recognition protein 2 (PGLYRP2)…”
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Phosphatase of Regenerating Liver 3 (PRL3) Provokes a Tyrosine Phosphoproteome to Drive Prometastatic Signal Transduction by Walls, Chad D., Iliuk, Anton, Bai, Yunpeng, Wang, Mu, Tao, W. Andy, Zhang, Zhong-Yin

“…Phosphatase of regenerating liver 3 (PRL3) is suspected to be a causative factor toward cellular metastasis when in excess. To date, the molecular basis for…”
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PRL-1 Protein Promotes ERK1/2 and RhoA Protein Activation through a Non-canonical Interaction with the Src Homology 3 Domain of p115 Rho GTPase-activating Protein by Bai, Yunpeng, Luo, Yong, Liu, Sijiu, Zhang, Lujuan, Shen, Kui, Dong, Yuanshu, Walls, Chad D., Quilliam, Lawrence A., Wells, Clark D., Cao, Youjia, Zhang, Zhong-Yin

“…Phosphatases of the regenerating liver (PRL) play oncogenic roles in cancer development and metastasis. Although previous studies indicate that PRL-1 promotes…”
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Seleninate in Place of Phosphate: Irreversible Inhibition of Protein Tyrosine Phosphatases by Abdo, Mohannad, Liu, Sijiu, Zhou, Bo, Walls, Chad D, Wu, Li, Knapp, Spencer, Zhang, Zhong-Yin

“…A homotyrosine based seleninic acid irreversibly inhibits protein tyrosine phosphatases by forming a covalent selenosulfide linkage with the active site…”
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beta-Tubulin mutations are associated with resistance to 2-methoxyestradiol in MDA-MB-435 cancer cells by Gökmen-Polar, Yesim, Escuin, Daniel, Walls, Chad D, Soule, Sharon E, Wang, Yuefang, Sanders, Kerry L, Lavallee, Theresa M, Wang, Mu, Guenther, Brian D, Giannakakou, Paraskevi, Sledge, Jr, George W

“…2-Methoxyestradiol is an estradiol metabolite with significant antiproliferative and antiangiogenic activity independent of estrogen receptor status. To…”
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Integrated Analysis of Global mRNA and Protein Expression Data in HEK293 Cells Overexpressing PRL-1: e72977 by Dumaual, Carmen M, Steere, Boyd A, Walls, Chad D, Wang, Mu, Zhang, Zhong-Yin, Randall, Stephen K

“…Background The protein tyrosine phosphatase PRL-1 represents a putative oncogene with wide-ranging cellular effects. Overexpression of PRL-1 can promote cell…”
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B-tubulin mutations are associated with resistance to 2-methoxyestradiol in MDA-MB-435 cancer cells by GÖKMEN-POLAR, Yesim, ESCUIN, Daniel, SLEDGE, George W, WALLS, Chad D, SOULE, Sharon E, YUEFANG WANG, SANDERS, Kerry L, LAVALLEE, Theresa M, MU WANG, GUENTHER, Brian D, GIANNAKAKOU, Paraskevi

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