Search Results - "Wallrath, L L"

Myopathic lamin mutations cause reductive stress and activate the nrf2/keap-1 pathway by Dialynas, George, Shrestha, Om K, Ponce, Jessica M, Zwerger, Monika, Thiemann, Dylan A, Young, Grant H, Moore, Steven A, Yu, Liping, Lammerding, Jan, Wallrath, Lori L

“…Mutations in the human LMNA gene cause muscular dystrophy by mechanisms that are incompletely understood. The LMNA gene encodes A-type lamins, intermediate…”
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Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling by Zwerger, Monika, Jaalouk, Diana E, Lombardi, Maria L, Isermann, Philipp, Mauermann, Monika, Dialynas, George, Herrmann, Harald, Wallrath, Lori L, Lammerding, Jan

“…Lamins are intermediate filament proteins that assemble into a meshwork underneath the inner nuclear membrane, the nuclear lamina. Mutations in the LMNA gene,…”
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Linking Heterochromatin Protein 1 (HP1) to cancer progression by Dialynas, George K, Vitalini, Michael W, Wallrath, Lori L

“…All cells of a given organism contain nearly identical genetic information, yet tissues display unique gene expression profiles. This specificity is in part…”
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The Influence of a Genetic Variant in CCDC78 on LMNA -Associated Skeletal Muscle Disease by Mohar, Nathaniel P, Cox, Efrem M, Adelizzi, Emily, Moore, Steven A, Mathews, Katherine D, Darbro, Benjamin W, Wallrath, Lori L

“…Mutations in the gene-encoding A-type lamins can cause Limb-Girdle muscular dystrophy Type 1B (LGMD1B). This disease presents with weakness and wasting of the…”
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Nuclear organization: taking a position on gene expression by Geyer, Pamela K, Vitalini, Michael W, Wallrath, Lori L

“…Eukaryotic genomes are divided into chromosomes that occupy defined regions or territories within the nucleus. These chromosome territories (CTs) are arranged…”
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The highly metastatic 4T1 breast carcinoma model possesses features of a hybrid epithelial-mesenchymal phenotype by Herndon, Mary E, Ayers, Mitchell, Gibson-Corley, Katherine, Wendt, Michael K, Wallrath, Lori L, Henry, Michael D, Stipp, Christopher S

“…Epithelial-mesenchymal transitions (EMTs) are thought to promote metastasis via downregulation of E-cadherin and upregulation of mesenchymal markers such as…”
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In Silico and In Vivo Analysis of Amino Acid Substitutions That Cause Laminopathies by Hinz, Benjamin E, Walker, Sydney G, Xiong, Austin, Gogal, Rose A, Schnieders, Michael J, Wallrath, Lori L

“…Mutations in the gene cause diseases called laminopathies. encodes lamins A and C, intermediate filaments with multiple roles at the nuclear envelope…”
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Connections between epigenetic gene silencing and human disease by Moss, Timothy J, Wallrath, Lori L

“…Alterations in epigenetic gene regulation are associated with human disease. Here, we discuss connections between DNA methylation and histone methylation,…”
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Cross talk between the cytoplasm and nucleus during development and disease by Wallrath, Lori L, Bohnekamp, Jens, Magin, Thomas M

“…Mechanotransduction is a process whereby mechanical stimuli outside the cell are sensed by components of the plasma membrane and transmitted as signals through…”
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Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells by Earle, Ashley J., Kirby, Tyler J., Fedorchak, Gregory R., Isermann, Philipp, Patel, Jineet, Iruvanti, Sushruta, Moore, Steven A., Bonne, Gisèle, Wallrath, Lori L., Lammerding, Jan

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Shining Light on the Dark Side of the Genome by Wallrath, Lori L, Rodriguez-Tirado, Felipe, Geyer, Pamela K

“…Heterochromatin has historically been considered the dark side of the genome. In part, this reputation derives from its concentration near centromeres and…”
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Preferential Dimethylation of Histone H4 Lysine 20 by Suv4-20 by Yang, Hongbo, Pesavento, James J., Starnes, Taylor W., Cryderman, Diane E., Wallrath, Lori L., Kelleher, Neil L., Mizzen, Craig A.

“…Post-translational modifications of histone tails direct nuclear processes including transcription, DNA repair, and chromatin packaging. Lysine 20 of histone…”
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Modulation of muscle redox and protein aggregation rescues lethality caused by mutant lamins by Coombs, Gary S., Rios-Monterrosa, Jose L., Lai, Shuping, Dai, Qiang, Goll, Ashley C., Ketterer, Margaret R., Valdes, Maria F., Uche, Nnamdi, Benjamin, Ivor J., Wallrath, Lori L.

“…Mutations in the human LMNA gene cause a collection of diseases called laminopathies, which includes muscular dystrophy and dilated cardiomyopathy. The LMNA…”
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Drosophila Models Reveal Properties of Mutant Lamins That Give Rise to Distinct Diseases by Walker, Sydney G, Langland, Christopher J, Viles, Jill, Hecker, Laura A, Wallrath, Lori L

“…Mutations in the gene cause a collection of diseases known as laminopathies, including muscular dystrophies, lipodystrophies, and early-onset aging syndromes…”
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Effects of mutant lamins on nucleo-cytoskeletal coupling in Drosophila models of LMNA muscular dystrophy by Shaw, Nicholas M, Rios-Monterrosa, Jose L, Fedorchak, Gregory R, Ketterer, Margaret R, Coombs, Gary S, Lammerding, Jan, Wallrath, Lori L

“…The nuclei of multinucleated skeletal muscles experience substantial external force during development and muscle contraction. Protection from such forces is…”
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Mechanisms of HP1-mediated gene silencing in Drosophila by Danzer, John R, Wallrath, Lori L

“…Heterochromatin Protein 1 (HP1) is a structural component of silent chromatin at telomeres and centromeres. Euchromatic genes repositioned near heterochromatin…”
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Does Heterochromatin Protein 1 Always Follow Code? by Li, Yuhong, Kirschmann, Dawn A., Wallrath, Lori L.

“…Heterochromatin protein 1 (HP1) is a conserved chromosomal protein that participates in chromatin packaging and gene silencing. A loss of HP1 leads to…”
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Effects of tethering HP1 to euchromatic regions of the Drosophila genome by Li, Yuhong, Danzer, John R, Alvarez, Pedro, Belmont, Andrew S, Wallrath, Lori L

“…Heterochromatin protein 1 (HP1) is a conserved non-histone chromosomal protein enriched in heterochromatin. On Drosophila polytene chromosomes, HP1 localizes…”
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Unfolding the mysteries of heterochromatin by Wallrath, Lori L

“…The function of heterochromatin has not been well understood. Recent studies, however, demonstrate that heterochromatin is essential for proper chromosome…”
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Comparative Study of Drosophila and Human A-Type Lamins by Schulze, Sandra R, Curio-Penny, Beatrice, Speese, Sean, Dialynas, George, Cryderman, Diane E, McDonough, Caitrin W, Nalbant, Demet, Petersen, Melissa, Budnik, Vivian, Geyer, Pamela K, Wallrath, Lori L

“…Nuclear intermediate filament proteins, called lamins, form a meshwork that lines the inner surface of the nuclear envelope. Lamins contain three domains: an…”
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