Search Results - "Wallin, Jeffrey"

Predictive markers of anti-VEGF and emerging role of angiogenesis inhibitors as immunotherapeutics by Hegde, Priti S., Wallin, Jeffrey J., Mancao, Christoph

“…The critical role of angiogenesis in promoting tumor growth and metastasis has been well established scientifically, and consequently blocking this pathway as…”
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Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma by Wallin, Jeffrey J., Bendell, Johanna C., Funke, Roel, Sznol, Mario, Korski, Konstanty, Jones, Suzanne, Hernandez, Genevive, Mier, James, He, Xian, Hodi, F. Stephen, Denker, Mitchell, Leveque, Vincent, Cañamero, Marta, Babitski, Galina, Koeppen, Hartmut, Ziai, James, Sharma, Neeraj, Gaire, Fabien, Chen, Daniel S., Waterkamp, Daniel, Hegde, Priti S., McDermott, David F.

“…Anti-tumour immune activation by checkpoint inhibitors leads to durable responses in a variety of cancers, but combination approaches are required to extend…”
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Impact of Blood-Brain Barrier Integrity on Tumor Growth and Therapy Response in Brain Metastases by Osswald, Matthias, Blaes, Jonas, Liao, Yunxiang, Solecki, Gergely, Gömmel, Miriam, Berghoff, Anna S, Salphati, Laurent, Wallin, Jeffrey J, Phillips, Heidi S, Wick, Wolfgang, Winkler, Frank

“…The role of blood-brain barrier (BBB) integrity for brain tumor biology and therapy is a matter of debate. We developed a new experimental approach using in…”
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Longitudinal liver sampling in patients with chronic hepatitis B starting antiviral therapy reveals hepatotoxic CD8+ T cells by Nkongolo, Shirin, Mahamed, Deeqa, Kuipery, Adrian, Sanchez Vasquez, Juan D, Kim, Samuel C, Mehrotra, Aman, Patel, Anjali, Hu, Christine, McGilvray, Ian, Feld, Jordan J, Fung, Scott, Chen, Diana, Wallin, Jeffrey J, Gaggar, Anuj, Janssen, Harry LA, Gehring, Adam J

“…Accumulation of activated immune cells results in nonspecific hepatocyte killing in chronic hepatitis B (CHB), leading to fibrosis and cirrhosis. This study…”
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Blocking viral entry with bulevirtide reduces the number of HDV-infected hepatocytes in human liver biopsies by Allweiss, Lena, Volmari, Annika, Suri, Vithika, Wallin, Jeffrey J, Flaherty, John F, Manuilov, Dmitry, Downie, Bryan, Lütgehetmann, Marc, Bockmann, Jan-Hendrik, Urban, Stephan, Wedemeyer, Heiner, Dandri, Maura

“…Bulevirtide (BLV) is a first-in-class entry inhibitor and the only approved treatment for patients chronically infected with HDV in Europe. We aimed to…”
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Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3' Kinase Inhibitor GDC-0941 in Breast Cancer Preclinical Models by O'BRIEN, Carol, WALLIN, Jeffrey J, BEIVIN, Marcia, FRIEDMAN, Lori S, LACKNER, Mark R, SAMPATH, Deepak, GUHATHAKURTA, Debraj, SAVAGE, Heidi, PUNNOOSE, Elizabeth A, GUAN, Jane, BERRY, Leanne, PRIOR, Wei Wei, AMLER, Lukas C

“…The class I phosphatidylinositol 3' kinase (PI3K) plays a major role in proliferation and survival in a wide variety of human cancers. A key factor in…”
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Targeting Activated Akt with GDC-0068, a Novel Selective Akt Inhibitor That Is Efficacious in Multiple Tumor Models by JIE LIN, SAMPATH, Deepak, LEE, Leslie B, RISOM, Tyler, GROSS, Stefan, LIEDERER, Bianca M, KOEPPEN, Hartmut, SKELTON, Nicholas J, WALLIN, Jeffrey J, BELVIN, Marcia, PUNNOOSE, Elizabeth, FRIEDMAN, Lori S, NANNINI, Michelle A, KUI LIN, LEE, Brian B, DEGTYAREV, Michael, OEH, Jason, SAVAGE, Heidi, ZHENGYU GUAN, HONG, Rebecca, KASSEES, Robert

“…We describe the preclinical pharmacology and antitumor activity of GDC-0068, a novel highly selective ATP-competitive pan-Akt inhibitor currently in clinical…”
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The TLR7 agonist vesatolimod induced a modest delay in viral rebound in HIV controllers after cessation of antiretroviral therapy by SenGupta, Devi, Brinson, Cynthia, DeJesus, Edwin, Mills, Anthony, Shalit, Peter, Guo, Susan, Cai, Yanhui, Wallin, Jeffrey J, Zhang, Liao, Humeniuk, Rita, Begley, Rebecca, Geleziunas, Romas, Mellors, John, Wrin, Terri, Jones, Norman, Milush, Jeffrey, Ferre, April L, Shacklett, Barbara L, Laird, Greg M, Moldt, Brian, Vendrame, Elena, Brainard, Diana M, Ramgopal, Moti, Deeks, Steven G

“…Toll-like receptor 7 (TLR7) agonists, in combination with other therapies, can induce sustained control of simian-human immunodeficiency virus (SHIV) or simian…”
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Safety, Pharmacokinetics, and Pharmacodynamics of the Oral TLR8 Agonist Selgantolimod in Chronic Hepatitis B by Gane, Edward J., Kim, Hyung Joon, Visvanathan, Kumar, Kim, Yoon Jun, Nguyen, Anh‐Hoa, Wallin, Jeffrey J., Chen, Diana Y., McDonald, Circe, Arora, Priyanka, Tan, Susanna K., Gaggar, Anuj, Roberts, Stuart K., Lim, Young‐Suk

“…Background and Aims In patients with chronic hepatitis B (CHB) infection, activation of toll‐like receptor 8 may induce antiviral immunity and drive functional…”
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Follicular Helper T (T FH ) Cell Targeting by TLR8 Signaling For Improving HBsAg-Specific B Cell Response In Chronic Hepatitis B Patients by Ayithan, Natarajan, Tang, Lydia, Tan, Susanna K, Chen, Diana, Wallin, Jeffrey J, Fletcher, Simon P, Kottilil, Shyam, Poonia, Bhawna

“…Identifying signaling pathways that induce B cell response can aid functional cure strategies for chronic hepatitis B infection (CHB). TLR8 activation with…”
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Liver stiffness measurement as a noninvasive method for the diagnosis of liver cirrhosis in patients with chronic hepatitis D virus infection by Sandmann, Lisa, Degasperi, Elisabetta, Port, Kerstin, Aleman, Soo, Wallin, Jeffrey J, Manuilov, Dmitry, Da, Ben L, Cornberg, Markus, Lampertico, Pietro, Maasoumy, Benjamin, Wedemeyer, Heiner, Deterding, Katja

“…Noninvasive tests (NITs) have been proposed as an alternative to liver biopsy for diagnosing liver cirrhosis. The evidence of NIT performance in patients with…”
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Safety and efficacy of the oral TLR8 agonist selgantolimod in individuals with chronic hepatitis B under viral suppression by Gane, Edward J., Dunbar, P. Rod, Brooks, Anna E., Zhang, Fangqiu, Chen, Diana, Wallin, Jeffrey J., van Buuren, Nicholas, Arora, Priyanka, Fletcher, Simon P., Tan, Susanna K., Yang, Jenny C., Gaggar, Anuj, Kottilil, Shyamasundaran, Tang, Lydia

“…Selgantolimod (GS-9688) is a Toll-like receptor 8 (TLR8) agonist that suppresses HBV in vitro. In a phase II study, we evaluated the safety and efficacy of…”
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RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy by Song, Kyung W, Edgar, Kyle A, Hanan, Emily J, Hafner, Marc, Oeh, Jason, Merchant, Mark, Sampath, Deepak, Nannini, Michelle A, Hong, Rebecca, Phu, Lilian, Forrest, William F, Stawiski, Eric, Schmidt, Stephen, Endres, Nicholas, Guan, Jane, Wallin, Jeffrey J, Cheong, Jonathan, Plise, Emile G, Lewis Phillips, Gail D, Salphati, Laurent, Heffron, Timothy P, Olivero, Alan G, Malek, Shiva, Staben, Steven T, Kirkpatrick, Donald S, Dey, Anwesha, Friedman, Lori S

“…is one of the most frequently mutated oncogenes; the p110a protein it encodes plays a central role in tumor cell proliferation. Small-molecule inhibitors…”
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HIV rebound in HIV controllers is associated with a specific fecal microbiome profile by Cai, Yanhui, Podlaha, Ondrej, Deeks, Steven G., Brinson, Cynthia, Ramgopal, Moti N., DeJesus, Edwin, Mills, Anthony, Shalit, Peter, Abdel‐Mohsen, Mohamed, Zhang, Liao, Vries, Christiaan R., Vendrame, Elena, SenGupta, Devi, Wallin, Jeffrey J.

“…HIV infection is associated with gut dysbiosis, and microbiome variability may affect HIV control when antiretroviral therapy (ART) is stopped. The TLR7…”
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GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway by Wallin, Jeffrey J, Edgar, Kyle A, Guan, Jane, Berry, Megan, Prior, Wei Wei, Lee, Leslie, Lesnick, John D, Lewis, Cristina, Nonomiya, Jim, Pang, Jodie, Salphati, Laurent, Olivero, Alan G, Sutherlin, Daniel P, O'Brien, Carol, Spoerke, Jill M, Patel, Sonal, Lensun, Letitia, Kassees, Robert, Ross, Leanne, Lackner, Mark R, Sampath, Deepak, Belvin, Marcia, Friedman, Lori S

“…Alterations of the phosphoinositide-3 kinase (PI3K)/Akt signaling pathway occur broadly in cancer via multiple mechanisms including mutation of the PIK3CA…”
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GDC-0941, a Novel Class I Selective PI3K Inhibitor, Enhances the Efficacy of Docetaxel in Human Breast Cancer Models by Increasing Cell Death In Vitro and In Vivo by WALLIN, Jeffrey J, GUAN, Jane, PRIOR, Wei Wei, LEE, Leslie B, BERRY, Leanne, BELMONT, Lisa D, KOEPPEN, Hartmut, BELVIN, Marcia, FRIEDMAN, Lori S, SAMPATH, Deepak

“…Docetaxel is a front-line standard-of-care chemotherapeutic drug for the treatment of breast cancer. Phosphoinositide 3-kinases (PI3K) are lipid kinases that…”
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Circulating immune and plasma biomarkers of time to HIV rebound in HIV controllers treated with vesatolimod by Abdel-Mohsen, Mohamed, Deeks, Steven, Giron, Leila, Hong, Kai Ying, Goldman, Aaron, Zhang, Liao, Huang, Susie S Y, Verrill, Donovan, Guo, Susan, Selzer, Lisa, de Vries, Christiaan R, Vendrame, Elena, SenGupta, Devi, Wallin, Jeffrey J, Cai, Yanhui

“…Antiretroviral therapy (ART) for HIV-1 treatment has improved lifespan but requires lifelong adherence for people living with HIV (PLWH), highlighting the need…”
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Mitochondrial N-formyl methionine peptides contribute to exaggerated neutrophil activation in patients with COVID-19 by Kuley, Runa, Duvvuri, Bhargavi, Wallin, Jeffrey J., Bui, Nam, Adona, Mary Vic, O'Connor, Nicholas G., Sahi, Sharon K., Stanaway, Ian B., Wurfel, Mark M., Morrell, Eric D., Liles, W. Conrad, Bhatraju, Pavan K., Lood, Christian

“…Neutrophil dysregulation is well established in COVID-19. However, factors contributing to neutrophil activation in COVID-19 are not clear. We assessed if…”
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Oral Selective TLR8 Agonist Selgantolimod Induces Multiple Immune Cell Responses in Humans by Ayithan, Natarajan, Ghosh, Alip, Dwivedi, Ankit, Wallin, Jeffrey J, Tan, Susanna K, Chen, Diana, Kottilil, Shyam, Poonia, Bhawna

“…TLR8 agonists have the potential for use as immunomodulatory components in therapeutic modalities for viral infections such as chronic HBV (CHB) and HIV. In…”
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Isoform-Specific Phosphoinositide 3-Kinase Inhibitors Exert Distinct Effects in Solid Tumors by EDGAR, Kyle A, WALLIN, Jeffrey J, BERRY, Megan, LEE, Leslie B, PRIOR, Wei Wei, SAMPATH, Deepak, FRIEDMAN, Lori S, BELVIN, Marcia

“…Therapeutic inhibitors are being developed against the phosphoinositide 3-kinase (PI3K) pathway, the deregulation of which drives tumor growth and survival in…”
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