Search Results - "Wallin, Jeff"

Abstract C201: A novel potent and selective inhibitor of PI3K/mTOR, GDC-0980, currently in phase I clinical trials by Friedman, Lori S., Belvin, Marcia, Berry, Leanne, Berry, Megan, Castanedo, Georgette, Edgar, Kyle, Folkes, Adrian, Guan, Jane, Heffron, Tim, Lesnick, John, Lewis, Cris, Nonomiya, Jim, Olivero, Alan, Patel, Sonal, Pang, Jodie, Prior, Wei Wei, Salphati, Laurent, Sampath, Deepak, Sutherlin, Dan, Wallin, Jeff, Zhu, Bingyan

“…Abstract Introduction: The phosphoinositide-3 kinase (PI3K)/Akt signaling pathway is deregulated in a wide variety of cancers. Somatic activating mutations and…”
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Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform by Staben, Steven T., Ndubaku, Chudi, Blaquiere, Nicole, Belvin, Marcia, Bull, Richard J., Dudley, Danette, Edgar, Kyle, Gray, Daniel, Heald, Robert, Heffron, Timothy P., Jones, Graham E., Jones, Mark, Kolesnikov, Aleks, Lee, Leslie, Lesnick, John, Lewis, Cristina, Murray, Jeremy, McLean, Neville J., Nonomiya, Jim, Olivero, Alan G., Ord, Rachel, Pang, Jodie, Price, Stephen, Prior, Wei Wei, Rouge, Lionel, Salphati, Laurent, Sampath, Deepak, Wallin, Jeff, Wang, Lan, Wei, BinQing, Weismann, Christian, Wu, Ping

“…A series of suitable five-membered heterocyclic alternatives to thiophenes within a thienobenzoxepin class of PI3-kinase (PI3K) inhibitors was discovered…”
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Abstract DDT02-01: Discovery of GDC-0032: A beta-sparing PI3K inhibitor active against PIK3CA mutant tumors by Olivero, Alan G., Heffron, Timothy P., Baumgardner, Matthew, Belvin, Marcia, Ross, Leanne Berry, Blaquiere, Nicole, Bradley, Erin, Castanedo, Georgette, Derynck, Mika, Do, Steven, Dotson, Jennafer, Dudley, Danette, Edgar, Kyle, Folkes, Adrian, Francis, Ross, Gianetti, Tony, Goldsmith, Richard, Goldsmith, Paul, Guan, Jane, Harrison, Trevor, Heald, Robert, Hsu, Jerry, Jackson, Phillip, Jones, Graham, Kim, Amy, Kolesnikov, Aleks, Lackner, Mark, Lee, Leslie, Lesnick, John, Lewis, Cristina, Mamounas, Michael, McLean, Neville, Murray, Jeremy, Ndubaku, Chudi, Nonomiya, Jim, Pang, Jodie, Pegg, Neil, Prior, Wei Wei, Salphati, Laurent, Sampath, Deepack, Sideris, Stephen, Siu, Michael, Staben, Steven, Sutherlin, Daniel, Ultsch, Mark, Wallin, Jeff, Wang, Lan, Wiesmann, Christian, Zhang, Xiaolin, Friedman, Lori S.

“…Abstract Modifications of the phosphoinositide-3 kinase (PI3K)/Akt signaling pathway are frequent in cancer due to multiple mechanisms, including activating…”
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Abstract 2787: Discovery of GDC-0980, a selective PI3K/mTOR inhibitor in clinical trials by Sutherlin, Daniel P., Belvin, Marcia, Bao, Linda, Berry, Leanne, Berry, Megan, Castanedo, Georgette, Edgar, Kyle, Folkes, Adrian, Friedman, Lori, Heffron, Tim, Patel, Sonal, Olivero, Alan, Lesnick, John, Lewis, Cristina, Marsters, James, Nonomiya, Jim, Pang, Jodie, Prior, Wei Wei, Salphati, Laurent, Sampath, Deepak, Tsui, Vickie, Wallin, Jeff, Wei, BinQing, Weismann, Christian, Zhu, Bing-Yan

“…Abstract PI3 Kinase and mTOR have been identified as promising targets for the treatment of cancer. These enzymes participate in related, but not redundant,…”
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